Protective effects of cinnamon on acetylcholinesterase activity and memory dysfunction in diabetic rats

Maryam Farazandeh; Ali Akbar Asghari; Sadegh Shabab; Narges Marefati; Arezoo Rajabian; Maryam Mahmoudabady; Mahmoud Hosseini

doi:10.1515/jcim-2022-0201

Article

Protective effects of cinnamon on acetylcholinesterase activity and memory dysfunction in diabetic rats

Maryam Farazandeh , Ali Akbar Asghari , Sadegh Shabab , Narges Marefati , Arezoo Rajabian , Maryam Mahmoudabady and Mahmoud Hosseini

Published/Copyright: December 28, 2022

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From the journal Journal of Complementary and Integrative Medicine Volume 20 Issue 2

Abstract

Objectives

Regarding neurocognitive and immunomodulatory properties of cinnamon (Cinn) we aimed to investigate whether cinnamon regulates acetylcholinesterase (AChE) activity, and oxidative abnormalities with concomitant memory dysfunction in streptozotocin (STZ)-induced diabetes.

Methods

Forty-seven male adult rats were divided into seven groups (n=8 animals): Control group: in these non-diabetic rats only saline 0.9% NaCl was gavaged, Diabetic (Dia) group: diabetic rats in them saline 0.9% NaCl was gavaged for six weeks. Dia-Cinn 100, Dia-Cinn 200, and Dia-Cinn 400, Dia-Met groups: in these diabetic rats the extract (100, 200, 400 mg/kg respectively) or metformin (300 mg/kg) was gavaged for six weeks. Passive avoidance performance, AChE enzyme activity, and oxidative indicators were examined among the groups.

Results

Vs. the control group, blood glucose level and stay time in the dark were remarkably increased in Dia group whereas the latency time was decreased. Meanwhile, antioxidant levels (superoxide dismutase, catalase, and thiols) noticeably decreased in the Dia group compared to the Control group. On the other hand, Cinn extract espicailly at the highest dose recovered the changes similar to those found in the metformin-treated group.

Conclusions

These findings proposed that the cinnamon hydro-ethanolic extract promotes memory recovery in diabetic conditions through the atteuation of the AChE activity and oxidative injury.

Keywords: acetylcholinesterase; blood glucose; cinnamon; diabetes mellitus; memory

Corresponding author: Mahmoud Hosseini, Ph.D. Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; and Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Phone: 98-51-38828565, Fax: 98-51-38828564, E-mail: hosseinim@mums.ac.ir

Maryam Farazandeh and Ali Akbar Asghari contributed equally to this work.

Funding source: Mashhad University of Medical Sciences

Award Identifier / Grant number: 991828

Research funding: This research was financially supported by Mashhad University of Medical Sciences (991828).
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Not applicable.
Ethical approval: The experiments were done under the supervision of by Institutional Ethical Committee (IR.MUMS.MEDICAL.REC.1400.270).

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Received: 2022-06-10

Accepted: 2022-12-11

Published Online: 2022-12-28

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Articles in the same Issue

https://doi.org/10.1515/jcim-2022-0201

Keywords for this article

acetylcholinesterase; blood glucose; cinnamon; diabetes mellitus; memory