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Physiological response of endurance exercise as a growth hormone mediator in adolescent women’s

  • Sugiharto EMAIL logo , Desiana Merawati , Adi Pranoto und Hendra Susanto
Veröffentlicht/Copyright: 3. Mai 2022
Journal of Basic and Clinical Physiology and Pharmacology
Aus der Zeitschrift Journal of Basic and Clinical Physiology and Pharmacology Band 34 Heft 1

Abstract

Objectives

Overweight status decreases the growth hormone (GH) secretion, thus, increasing the risk factors for medical complications. However, proper exercise is reported to enhance GH and affect the energy balance. Therefore, exercise is proclaimed to be an accurate and engaging therapy to increase GH in preventing overweight. This study aims to investigate the physiological response of exercise in mediating the increase of GH secretion in female adolescents.

Methods

22 overweight women aged 19–20 years old, with maximal oxygen consumption of 27–35 mL/kg/min, were selected as sample size. They were divided into three groups, namely (CONT, n=7) Control, (MIEE, n=7) Moderate-intensity interval endurance exercise, and (MCEE, n=8) Moderate-intensity continuous endurance exercise. The exercise was carried out by running for 30–35 min using treadmills with an intensity of 60–70% HRmax. The blood sampling for GH examination was carried out four times before exercise, 10 min, 6 h, and 24 h after exercise. The enzyme-linked immunosorbent assay (ELISA) was used to measure the GH and IGF-1 levels. The data analysis was carried out using a one-way ANOVA test, with a significance level of 5%.

Results

The results of the one-Way ANOVA test suggested a significantly different average GH and IGF-1 before and after the exercise between the three groups (CON, MIEE, and MCEE) (p≤0.05).

Conclusions

MCEE increases the GH and IGF-1 levels more considerably than MIEE. Therefore, exercise is a mediator to increase GH and IGF-1 secretion in overweight individuals. Exercise could be a viable therapy for overweight people.

Keywords: growth hormone; moderate-intensity exercise; overweight; therapeutics
Corresponding author: Sugiharto, Department of Sport Science, Faculty of Sport Science, Universitas Negeri Malang, Malang, Indonesia, Phone: +62 81 334 274 994, E-mail:

Funding source: Universitas Negeri Malang http://dx.doi.org/10.13039/501100015517

Award Identifier / Grant number: 4.3.758/UN32.14.1/LT/2020

Acknowledgments

We would like to express our gratitude to the Faculty of Sports Science, Universitas Negeri Malang, and the Health Center of the Ministry of Health of Malang to provide facilities, the Blood Transfusion Unit of the Indonesian Red Cross Malang to assist in the handling of blood centrifuges, and Laboratory of Physiology, Faculty of Medicine, Universitas Brawijaya, assist in the analysis of GH and IGF-1 levels.

  1. Research funding: This study was supported by the PNBP research grant 2020, Universitas Negeri Malang, Indonesia, under Grant Number: 4.3.758/UN32.14.1/LT/2020.

  2. Author contribution: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors declare no competing interests.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: Based on the ethical standards of the Declaration of Helsinki 1975, this study has been approved by the Health Research Ethics Commission, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia session and obtained approval by registration number (26/EC/KEPK-S1/02/2020).

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Received: 2022-02-24
Revised: 2022-04-07
Accepted: 2022-04-09
Published Online: 2022-05-03

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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  4. Reviews
  5. Catheter-associated urinary tract infection: an overview
  6. Liver and heart failure: an ultrasound relationship
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  11. Analgesic effect of curcumin topical formulation in knee osteoarthritis patients: a clinical trial
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  14. Physiological response of endurance exercise as a growth hormone mediator in adolescent women’s
  15. Effect of Om chanting and Yoga Nidra on depression anxiety stress, sleep quality and autonomic functions of hypertensive subjects – a randomized controlled trial
  16. Effectiveness of electrical vestibular nerve stimulation as adjunctive therapy to improve the cognitive functions in patients with Parkinson’s disease
  17. Role of interleukin-22 in tuberculosis patients
  18. Effect of aspirin on the TNF-α-mediated cell survival and death pathways in breast cancer
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https://doi.org/10.1515/jbcpp-2022-0060
Schlagwörter für diesen Artikel
growth hormone; moderate-intensity exercise; overweight; therapeutics

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Peyronie’s disease: where are we at?
  4. Reviews
  5. Catheter-associated urinary tract infection: an overview
  6. Liver and heart failure: an ultrasound relationship
  7. Original Articles
  8. The intracellular fluid compartment is smaller than commonly believed when measured by whole-body bioimpedance
  9. Prevalence and distribution of causes of infertility according to women’s age – a cross-sectional study in a tertiary healthcare hospital setup
  10. Supplementation of antihypertensive drug regimen with vitamin E ameliorates alterations of primary haemodynamic parameters and total antioxidant capacity in ovariectomised rats
  11. Analgesic effect of curcumin topical formulation in knee osteoarthritis patients: a clinical trial
  12. ProACT in the management of stress urinary incontinence after radical prostatectomy. What happens after 8 years of follow up? monocentric analysis in 42 patients
  13. The effect of metformin on the metabolism of human vascular smooth muscle cells in high glucose conditions
  14. Physiological response of endurance exercise as a growth hormone mediator in adolescent women’s
  15. Effect of Om chanting and Yoga Nidra on depression anxiety stress, sleep quality and autonomic functions of hypertensive subjects – a randomized controlled trial
  16. Effectiveness of electrical vestibular nerve stimulation as adjunctive therapy to improve the cognitive functions in patients with Parkinson’s disease
  17. Role of interleukin-22 in tuberculosis patients
  18. Effect of aspirin on the TNF-α-mediated cell survival and death pathways in breast cancer
  19. Resting heart rate variability as a diagnostic marker of cardiovascular dysautonomia in postural tachycardia syndrome
  20. Effects of intensity and training on cardiovascular responses to the Valsalva maneouvre
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