Effectiveness of electrical vestibular nerve stimulation as adjunctive therapy to improve the cognitive functions in patients with Parkinson’s disease
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Sai Sailesh Kumar Goothy
,
Sudhir Gawarikar
Abstract
Objectives
The present study was undertaken to observe the effectiveness of electrical vestibular stimulation in improving cognitive functions in patients with Parkinson’s disease.
Methods
Randomized controlled trial (ClinicalTrials.gov Identifier: NCT04450550). 30 cases of PD, including both males and females were recruited in the study by convenient sampling after obtaining written informed consent. After recruiting, the participants were randomly assigned into two groups. The control group (n=15) received placebo stimulation whereas the intervention group (n=15) received electrical vestibular stimulation administered for 12 weeks. Auditory, visual reaction time and spatial and verbal memory were recorded before and after 6 weeks and after 12 weeks of intervention and compared.
Results
There was a significant improvement in both auditory and visual reaction time of right and left-hand responses. Also, significant improvement was observed in both the spatial and verbal memory of the patients.
Conclusions
There was a significant improvement in the auditory and visual reaction time and spatial and verbal memory in the participants after the electrical vestibular nerve stimulation administration. No side effects were reported by the study participants and they have expressed willingness to continue the intervention after the study period also. The study recommends further detailed studies with a higher sample size to adopt electrical vestibular nerve stimulation as adjunctive therapy in the management of Parkinson’s disease.
Funding source: Indian Council of Medical Research
Award Identifier / Grant number: 2020-1352
Funding source: Neurovalens (Belfast, UK).
Award Identifier / Grant number: The devices used in this study were provided
Acknowledgments
The authors express sincere thanks to Dr. Vijaya Raghavan, Research Director, Saveetha University for his constant support throughout the study. The authors are also thankful to the management of R.D. Gardi Medical College for arranging all facilities to conduct the study smoothly.
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Research funding: The study was funded by the Indian Council of Medical Research (ICMR-2020-1352). The devices used in this study were provided by Neurovalens (Belfast, UK).
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The devices used in this study were provided by Neurovalens (Belfast, UK).
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The study protocol was approved by the institutional human ethical committee of R.D. Gardi Medical College. (IEC Ref. N0- 124/2019).
References
1. Kalia, LV, Lang, AE. Parkinson’s disease. Lancet 2015;386:896–912. https://doi.org/10.1016/s0140-6736(14)61393-3.Search in Google Scholar
2. Hely, MA, Reid, WGJ, Adena, MA, Halliday, GM, Morris, JGL. The Sydney multicenter study of Parkinson’s disease: the inevitability of dementia at 20 years. Mov Disord 2008;23:837–44. https://doi.org/10.1002/mds.21956.Search in Google Scholar
3. Fang, C, Lv, L, Mao, S, Dong, H, Liu, B. Cognition deficits in Parkinson’s disease: mechanisms and treatment. Parkinsons Dis 2020;24:2076942.10.1155/2020/2076942Search in Google Scholar
4. Aarsland, D, Larsen, JP, Karlsen, K, Lim, NG, Tandberg, E. Mental symptoms in Parkinson’s disease are important contributors to caregiver distress. Int J Geriatr Psychiatr 1999;14:866–74. https://doi.org/10.1002/(sici)1099-1166(199910)14:10<866::aid-gps38>3.0.co;2-z.10.1002/(SICI)1099-1166(199910)14:10<866::AID-GPS38>3.0.CO;2-ZSearch in Google Scholar
5. Kumar, SS, Archana, R, Mukkadan, JK. Effect of vestibular stimulation on spatial and verbal memory in college students. Natl Med J India 2017;30:337–9. https://doi.org/10.4103/0970-258x.239077.Search in Google Scholar
6. Smith, PF. Dyscalculia and vestibular function. Med Hypotheses 2012;79:493–6. https://doi.org/10.1016/j.mehy.2012.06.032.Search in Google Scholar
7. Besnard, S, Machado, ML, Vignaux, G, Boulouard, M, Coquerel, A, Bouet, V, et al.. Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors. Hippocampus 2012;22:814–26. https://doi.org/10.1002/hipo.20942.Search in Google Scholar
8. Baek, JH, Zheng, Y, Darlington, CL, Smith, PF. Evidence that spatial memory deficits following bilateral vestibular deafferentation in rats are probably permanent. Neurobiol Learn Mem 2010;94:402–13. https://doi.org/10.1016/j.nlm.2010.08.007.Search in Google Scholar
9. Brandt, T, Schautzer, F, Hamilton, DA, Brüning, R, Markowitsch, HJ, Kalla, R, et al.. Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. Brain 2005;128:2732–41. https://doi.org/10.1093/brain/awh617.Search in Google Scholar
10. Mohan, M, Thombre, DP, Das, AK, Subramanian, N, Chandrasekar, S. Reaction time in clinical diabetes mellitus. Indian J Physiol Pharmacol 1984;28:311–4.Search in Google Scholar
11. Rajagopalan, A, Kumar, SS, Mukkadan, JK. Effect of vestibular stimulation on auditory and visual reaction time in relation to stress. J Adv Pharm Technol Res 2017;8:34–8. https://doi.org/10.4103/2231-4040.197390.Search in Google Scholar
12. Goothy, SSK, McKeown, J. Modulation of sleep using electrical vestibular nerve stimulation prior to sleep onset: a pilot study. J Basic Clin Physiol Pharmacol 2020;32:19–23. https://doi.org/10.1515/jbcpp-2020-0019.Search in Google Scholar PubMed
13. Baddeley, AD. Your memory—a user’s guide. New York: Avery; 1993.Search in Google Scholar
14. Naveen, KV, Nagarathna, R, Nagendra, HR, Telles, S. Yoga breathing through a particular nostril increases spatial memory scores without lateralized effects. Psychol Rep 1997;81:555–61. https://doi.org/10.2466/pr0.81.6.555-561.Search in Google Scholar
15. Russel, P. The brain book. London: Routledge Kegen Paul; 1979.Search in Google Scholar
16. Kamble, JP, Deshpande, VK, Phatak, MS. The study of auditory and visual reaction times in chronic smokers. Int J Med Health Sci 2013;2:18–22.Search in Google Scholar
17. Solanki, J, Joshi, N, Shah, C, Mehta, HB, Gokhle, PA. Study of correlation between auditory and visual reaction time in healthy adults. Int J Med Publ Health 2012;2:36–8. https://doi.org/10.5530/ijmedph.2.2.8.Search in Google Scholar
18. Jakobsen, LH, Sorensen, JM, Rask, IK, Jensen, BS, Kondrup, J. Validation of reaction time as a measure of cognitive function and quality of life in healthy subjects and patients. Nutrition 2011;27:561–70. https://doi.org/10.1016/j.nut.2010.08.003.Search in Google Scholar PubMed
19. Teichner, WH. Recent studies of simple reaction time. Psychol Bull 1954;51:128–49. https://doi.org/10.1037/h0060900.Search in Google Scholar PubMed
20. Tsang, WW, Fong, SS, Cheng, YT, Daswani, DD, Lau, HY, Lun, CK, et al.. The effect of vestibular stimulation on eye-hand coordination and postural control in elite basketball players. Am J Sports Sci 2014;2:17–22. https://doi.org/10.11648/j.ajss.20140202.12.Search in Google Scholar
21. Wang, J, Wang, Y, Ren, Y. A case-control study on balance function of attention deficit hyperactivity disorder (ADHD) children. Beijing Xue Xue Bao 2003;35:280–3.Search in Google Scholar
22. Lopez, C, Blanke, O, Mast, FW. The human vestibular cortex was revealed by coordinate-based activation likelihood estimation meta-analysis. Neuroscience 2012;212:159–79. https://doi.org/10.1016/j.neuroscience.2012.03.028.Search in Google Scholar PubMed
23. Ferrè, ER, Bottini, G, Haggard, P. Vestibular modulation of somatosensory perception. Eur J Neurosci 2011;34:1337–44. https://doi.org/10.1111/j.1460-9568.2011.07859.x.Search in Google Scholar PubMed
24. Ferrè, ER, Sedda, A, Gandola, M, Bottini, G. How the vestibular system modulates tactile perception in normal subjects: a behavioral and physiological study. Exp Brain Res 2011;208:29–38. https://doi.org/10.1007/s00221-010-2450-9.Search in Google Scholar PubMed
25. Haghshenas, S, Hosseini, MS, Aminjan, AS. A possible correlation between vestibular stimulation and auditory comprehension in children with attention-deficit/hyperactivity disorder. Psychol Neurosci 2014;7:159–62. https://doi.org/10.3922/j.psns.2014.009.Search in Google Scholar
26. Archana, R, Rani, S, Kumari, SK. The effectiveness of vestibular stimulation by rocking and vestibular exercises on auditory and visual reaction time and quality of life in elderly. Indian J Public Health Res Dev 2020;11:55–60.Search in Google Scholar
27. Yamamoto, Y, Struzik, ZR, Soma, R, Ohashi, K, Kwak, S. Noisy vestibular stimulation improves autonomic and motor responsiveness in central neurodegenerative disorders. Ann Neurol 2005;58:175–81. https://doi.org/10.1002/ana.20574.Search in Google Scholar PubMed
28. Preuss, N, Mast, FW, Hasler, G. Purchase decision-making is modulated by vestibular stimulation. Front Behav Neurosci 2014;8:51. https://doi.org/10.3389/fnbeh.2014.00051.Search in Google Scholar PubMed PubMed Central
29. Allum, JH, Pfaltz, CR. Visual and vestibular contributions to pitch sway stabilization in the ankle muscles of normals and patients with bilateral peripheral vestibular deficits. Exp Brain Res 1985;58:82–94. https://doi.org/10.1007/bf00238956.Search in Google Scholar
30. Smith, PF, Zheng, Y, Horii, A, Darlington, CL. Does vestibular damage cause cognitive dysfunction in humans? J Vestib Res 2005;15:1–9. https://doi.org/10.3233/ves-2005-15101.Search in Google Scholar
31. Gopinath, A, Rajagopalan, A, Goothy, SSK, Mukkadan, JK. Effect of caloric vestibular stimulation on memory. Int J Pharm Bio Sci 2015;6:453–9.Search in Google Scholar
32. Gavrilov, VV, Wiener, SI, Berthoz, A. Enhanced hippocampal theta EEG during whole body rotations in awake restrained rats. Neurosci Lett 1995;197:239–41. https://doi.org/10.1016/0304-3940(95)11918-m.Search in Google Scholar PubMed
33. Schlosser, N, Wolf, OT, Wingenfeld, K. Cognitive correlates of hypothalamic–pituitary–adrenal axis in major depression. Expert Rev Endocrinol Metab 2011;6:109–26. https://doi.org/10.1586/eem.10.79.Search in Google Scholar PubMed
34. Vitte, E, Derosier, C, Caritu, Y, Berthoz, A, Hasboun, D, Soulié, D. Activation of the hippocampal formation by vestibular stimulation: a functional magnetic resonance imaging study. Exp Brain Res 1996;112:523–6. https://doi.org/10.1007/bf00227958.Search in Google Scholar PubMed
35. Furman, JM, Redfern, MS, Fuhrman, SI, Jennings, JR. Visual–vestibular stimulation influences spatial and non-spatial cognitive processing. J Vestib Res 2012;22:253–9. https://doi.org/10.3233/ves-2012-00460.Search in Google Scholar PubMed PubMed Central
36. Rogge, AK, Röder, B, Zech, A, Nagel, V, Hollander, K, Braumann, KM, et al.. Balance training improves memory and spatial cognition in healthy adults. Sci Rep 2017;7:5661. https://doi.org/10.1038/s41598-017-06071-9.Search in Google Scholar PubMed PubMed Central
37. Brandt, T, Schautzer, F, Hamilton, DA, B¨ning, R, Markowitsch, HJ, Kalla, R, et al.. Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. Brain 2005;128:2732–274. https://doi.org/10.1093/brain/awh617.Search in Google Scholar PubMed
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Articles in the same Issue
- Frontmatter
- Editorial
- Peyronie’s disease: where are we at?
- Reviews
- Catheter-associated urinary tract infection: an overview
- Liver and heart failure: an ultrasound relationship
- Original Articles
- The intracellular fluid compartment is smaller than commonly believed when measured by whole-body bioimpedance
- Prevalence and distribution of causes of infertility according to women’s age – a cross-sectional study in a tertiary healthcare hospital setup
- Supplementation of antihypertensive drug regimen with vitamin E ameliorates alterations of primary haemodynamic parameters and total antioxidant capacity in ovariectomised rats
- Analgesic effect of curcumin topical formulation in knee osteoarthritis patients: a clinical trial
- ProACT in the management of stress urinary incontinence after radical prostatectomy. What happens after 8 years of follow up? monocentric analysis in 42 patients
- The effect of metformin on the metabolism of human vascular smooth muscle cells in high glucose conditions
- Physiological response of endurance exercise as a growth hormone mediator in adolescent women’s
- Effect of Om chanting and Yoga Nidra on depression anxiety stress, sleep quality and autonomic functions of hypertensive subjects – a randomized controlled trial
- Effectiveness of electrical vestibular nerve stimulation as adjunctive therapy to improve the cognitive functions in patients with Parkinson’s disease
- Role of interleukin-22 in tuberculosis patients
- Effect of aspirin on the TNF-α-mediated cell survival and death pathways in breast cancer
- Resting heart rate variability as a diagnostic marker of cardiovascular dysautonomia in postural tachycardia syndrome
- Effects of intensity and training on cardiovascular responses to the Valsalva maneouvre
