Role of interleukin-22 in tuberculosis patients
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Shruti Gupta
,
Kavya Gauba
,
Jyoti Shekhawat
Abstract
Objectives
Disease progression of tuberculosis (TB) depends on the balance between the microorganism’s virulence and the host defense systems (mainly T cell-mediated immune response). Interleukin-22 (IL-22) helps in cell proliferation and regeneration and provides protection against microbial diseases. The IL-22-producing T cells can migrate into the granulomas during TB infection. However, disparity exists in literature regarding its role. The present study aims to compare serum IL-22 levels and its’ expression in TB patients and healthy controls.
Methods
87 TB patients and 85 healthy subjects were enrolled in the study. Under aseptic conditions, venous blood was withdrawn. Serum IL-22 levels were estimated using enzyme-linked immunosorbent assay, and its gene expression was assessed using SYBR green-based quantitative PCR technology. A statistical analysis was performed using SPSS.
Results
The median (interquartile range) of serum IL-22 levels was significantly lower in TB patients (18.55 (5.08) pg/mL) when compared to controls (49.38 (162.88) pg/mL) (p<0.0001). The IL-22 expression was significantly upregulated with a fold change value of 29.44 in TB patients.
Conclusions
The IL-22 levels were found to be significantly decreased in patients, contradictory to its expression, which is upregulated. It plays a crucial role for the modulation of tissues in response to TB infection.
Funding source: All India Institute of medical sciences Jodhpur
Award Identifier / Grant number: PG dissertation fund
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Research funding: The study was funded by All India Institute of Medical Sciences, Jodhpur, India.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Not applicable.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The study was approved by the Institutional Ethical Committee of All India Institute of Medical Sciences, Jodhpur, India bearing IEC No. 2020/3353.
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Articles in the same Issue
- Frontmatter
- Editorial
- Peyronie’s disease: where are we at?
- Reviews
- Catheter-associated urinary tract infection: an overview
- Liver and heart failure: an ultrasound relationship
- Original Articles
- The intracellular fluid compartment is smaller than commonly believed when measured by whole-body bioimpedance
- Prevalence and distribution of causes of infertility according to women’s age – a cross-sectional study in a tertiary healthcare hospital setup
- Supplementation of antihypertensive drug regimen with vitamin E ameliorates alterations of primary haemodynamic parameters and total antioxidant capacity in ovariectomised rats
- Analgesic effect of curcumin topical formulation in knee osteoarthritis patients: a clinical trial
- ProACT in the management of stress urinary incontinence after radical prostatectomy. What happens after 8 years of follow up? monocentric analysis in 42 patients
- The effect of metformin on the metabolism of human vascular smooth muscle cells in high glucose conditions
- Physiological response of endurance exercise as a growth hormone mediator in adolescent women’s
- Effect of Om chanting and Yoga Nidra on depression anxiety stress, sleep quality and autonomic functions of hypertensive subjects – a randomized controlled trial
- Effectiveness of electrical vestibular nerve stimulation as adjunctive therapy to improve the cognitive functions in patients with Parkinson’s disease
- Role of interleukin-22 in tuberculosis patients
- Effect of aspirin on the TNF-α-mediated cell survival and death pathways in breast cancer
- Resting heart rate variability as a diagnostic marker of cardiovascular dysautonomia in postural tachycardia syndrome
- Effects of intensity and training on cardiovascular responses to the Valsalva maneouvre
