Protective effects of Vitex pseudo-negundo leaves on diabetic-induced nephropathy in rats

Hasan Rezaei Seresht; Esrafil Mansouri; Mahsa Daei Milani; Bahareh Vahidiyanfar; Arash Ramezanpour Shahi; Mohammad Javad Namazi; Hossein Moallaei; Maryam Latifnia; Mojtaba Fattahi Abdizadeh

doi:10.1515/jbcpp-2019-0308

Artikel

Protective effects of Vitex pseudo-negundo leaves on diabetic-induced nephropathy in rats

Hasan Rezaei Seresht , Esrafil Mansouri , Mahsa Daei Milani , Bahareh Vahidiyanfar , Arash Ramezanpour Shahi , Mohammad Javad Namazi , Hossein Moallaei , Maryam Latifnia und Mojtaba Fattahi Abdizadeh

Veröffentlicht/Copyright: 10. August 2020

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Aus der Zeitschrift Journal of Basic and Clinical Physiology and Pharmacology Band 32 Heft 1

Abstract

Objectives

The belief of therapeutic effects of herbal remedies in diseases such as diabetes is rooted in medical history. The present study evaluated protective efficacy of the hydroalcoholic extract of Vitex pseudo-negundo leaves (VLHE) on the renal disorders in streptozotocin-induced diabetic rats.

Methods

Fifty Wistar male rats were recruited and divided into five groups of 10, including healthy controls and diabetic controls: three diabetic groups of which first group was treated with glibenclamide, and two groups treated with 250 and 500 mg/kg of VLHE, respectively, for six weeks. Renal biochemical tests and tissue histopathological evaluation were performed and the antioxidant status was examined.

Results

There were significant decreases in superoxide dismutase and glutathione peroxidase activities and increases in malondialdehyde levels in renal tissue of diabetic groups compared with healthy controls. In the VLHE-treated rats, fasting blood sugar, blood urea nitrogen and creatinine were declined, serum albumin elevated, kidney weight lowered, lipid peroxidation and reinforcement of the activities of antioxidant enzymes decreased compared with healthy groups. Histological assessments revealed that the vacuolar degeneration of tubules and shrinkage of glomeruli in VLHE-treated rats was decreased compared with diabetic rats.

Conclusions

The study suggested that administrating of VLHE in nephropathic rats ameliorated the disease by reduction of oxidative stress and increase in renal antioxidant enzyme activities.

Keywords: antioxidant enzymes; diabetic nephropathy; oxidative stress; Vitex pseudo-negundo

Corresponding authors: Mojtaba Fattahi Abdizadeh, PhD, Department of Lab sciences, Faculty of Paramedicine, Sabzevar University of Medical Sciences, Sabzevar, Iran, Phone: +98-5144018335, E-mail: mojtabafattahi@gmail.com; and Mohammad Javad Namazi, Department of Microbiology, Immunology and Parsitology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran; and College of Medical, Veterinary and Life Sciences, the Institute of Infection, Immunity and Inflammation, Glasgow University, UK, Phone: +98-5144018335, E-mail: mjnamazi@gmail.com

Hasan Rezaei Seresht and Esrafil Mansouri contributed equally to this work.

Funding source: Sabzevar University of Medical Sciences

Acknowledgments

This research has been financially supported by SUMS, Sabzevar, Iran.

Research funding: The authors declare that the fund for this work was granted by the deputy of research and technology at Sabzevar University of Medical Sciences.
Author contributions: It is stated that all authors named in the title page have accepted responsibility for their own contributions and the entire content of the present manuscript and authorized the corresponding authors to submit the paper.
Competing interests: There are no conflicts of interests to be declared.
Ethical approval: The medical ethics of Sabzevar University of Sabzevar has approved performing all experimental works on animal models used in this study (ethical code: IR. Medsab, Rec.1393.55, 393040166).

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Received: 2019-10-22

Accepted: 2020-04-08

Published Online: 2020-08-10

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Artikel in diesem Heft

https://doi.org/10.1515/jbcpp-2019-0308

Schlagwörter für diesen Artikel

antioxidant enzymes; diabetic nephropathy; oxidative stress; Vitex pseudo-negundo