Phoenix dactylifera Linn fruit based-diets palliate hyperglycemia in alloxan-induced diabetic rats
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Basiru Olaitan Ajiboye
Abstract
Objectives
This study was designed to examine the in vitro inhibitory activities of vital enzymes related to diabetes mellitus and different biochemical parameters of Phoenix dactylifera fruit based-diet in alloxan-induced diabetic rats.
Methods
The aqueous extract of P. dactylifera fruit based-diet was prepared and used for determination of in vitro antioxidants as well as α-amylase and α-glucosidase inhibitory activities using standard procedures. Also, 30 albino rats were induced by a single intraperitoneal injection of 150 mg/kg body weight of alloxan and grouped into A–D as normal rats placed on Dioscorea rotundata based-diet, diabetic control rats placed on D. rotundata based-diet, diabetic rats placed on D. rotundata based-diet and administered metformin orally per day, and diabetic rats placed on P. dactylifera fruit based-diet respectively. The animals were sacrificed on the fourth week of the experiment, and different biochemical parameters were evaluated.
Results
The P. dactylifera fruit based-diet extract demonstrated antioxidative potentials and inhibition against α-amylase and α-glucosidase activities in a dose-dependent manner. In addition, diabetic rats placed on the P. dactylifera fruit based-diet revealed significant (p<0.05) increase in body weight, insulin and glycogen levels, antioxidant enzyme activities, GLUT 2 and high density lipoprotein (HDL) concentrations when compared with the diabetic control group. Also, diabetic rats placed on P. dactylifera fruit based-diet indicate significant (p<0.05) reduction in fasting blood glucose, lipid peroxidation, cytokines levels, some gluconeogenesis enzyme activities, cholesterol, triglycerides, low-density lipoproteins and very low-density lipoproteins concentrations compared to the diabetic control animals.
Conclusion
This diet could be an alternative nutraceutical means of managing diabetes mellitus and its complications.
Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: No applicable.
Ethical approval: Research involving animals complied with all relevant national regulations and institutional policies of University of Ilorin Ethical Committee (2012) for the care and use of animals. (026-Nr.: BCH/SCI). The local Institutional Review Board deemed the study exempt from review.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Review
- Phytochemical profile and pharmacological properties of Trifolium repens
- Original Articles
- Bacopa monnieri alleviates aluminium chloride-induced anxiety by regulating plasma corticosterone level in Wistar rats
- Antidepressant-like effect of Albizia zygia root extract in murine models
- A study of serum cortisol levels in acute head injury patients
- Ferulic acid through mitigation of NMDA receptor pathway exerts anxiolytic-like effect in mouse model of maternal separation stress
- Aberrant pain modulation in trigeminal neuralgia patients
- Phoenix dactylifera Linn fruit based-diets palliate hyperglycemia in alloxan-induced diabetic rats
- Protective effects of Vitex pseudo-negundo leaves on diabetic-induced nephropathy in rats
- Ameliorative effect of Neera, nonfermented coconut inflorescence sap, on cisplatin-induced renal toxicity by abating oxidative stress
- The effect of Rheum ribes L. on oxidative stress in diabetic rats
- Effects of honey supplementation on renal dysfunction and metabolic acidosis in rats with high-fat diet-induced chronic kidney disease
- Co-administration of prazosin and propranolol with glibenclamide improves anti-oxidant defense system in endothelial tissue of streptozotocin-induced diabetic Wistar rats
- Calcium and s100a1 protein balance in the brain–heart axis in diabetic male Wistar rats
- Evaluation of efficacy of Aloe vera (L.) Burm. f. gel solution in methylcellulose-induced ocular hypertension in New Zealand white rabbits
- Haematoprotective and red blood cell membrane stabilizing effects of Justicia carnae leaf extracts in sodium nitrate-treated rats
- Leaf and root bark extracts of Ziziphus abyssinica Hochst ex. A. Rich (Rhamnaceae) ameliorate hepatic, renal and splenic injuries induced by phenylhydrazine in rats
- Antinociceptive, anti-inflammatory and antioxidant effects of Boerhavia coccinea extracts and fractions on acute and persistent inflammatory pain models
- Case Report
- Atorvastatin-linked rhabdomyolysis caused by the simultaneous intake of amoxicillin clavulanic acid
- Miscellaneous
- Acknowledgment
Artikel in diesem Heft
- Review
- Phytochemical profile and pharmacological properties of Trifolium repens
- Original Articles
- Bacopa monnieri alleviates aluminium chloride-induced anxiety by regulating plasma corticosterone level in Wistar rats
- Antidepressant-like effect of Albizia zygia root extract in murine models
- A study of serum cortisol levels in acute head injury patients
- Ferulic acid through mitigation of NMDA receptor pathway exerts anxiolytic-like effect in mouse model of maternal separation stress
- Aberrant pain modulation in trigeminal neuralgia patients
- Phoenix dactylifera Linn fruit based-diets palliate hyperglycemia in alloxan-induced diabetic rats
- Protective effects of Vitex pseudo-negundo leaves on diabetic-induced nephropathy in rats
- Ameliorative effect of Neera, nonfermented coconut inflorescence sap, on cisplatin-induced renal toxicity by abating oxidative stress
- The effect of Rheum ribes L. on oxidative stress in diabetic rats
- Effects of honey supplementation on renal dysfunction and metabolic acidosis in rats with high-fat diet-induced chronic kidney disease
- Co-administration of prazosin and propranolol with glibenclamide improves anti-oxidant defense system in endothelial tissue of streptozotocin-induced diabetic Wistar rats
- Calcium and s100a1 protein balance in the brain–heart axis in diabetic male Wistar rats
- Evaluation of efficacy of Aloe vera (L.) Burm. f. gel solution in methylcellulose-induced ocular hypertension in New Zealand white rabbits
- Haematoprotective and red blood cell membrane stabilizing effects of Justicia carnae leaf extracts in sodium nitrate-treated rats
- Leaf and root bark extracts of Ziziphus abyssinica Hochst ex. A. Rich (Rhamnaceae) ameliorate hepatic, renal and splenic injuries induced by phenylhydrazine in rats
- Antinociceptive, anti-inflammatory and antioxidant effects of Boerhavia coccinea extracts and fractions on acute and persistent inflammatory pain models
- Case Report
- Atorvastatin-linked rhabdomyolysis caused by the simultaneous intake of amoxicillin clavulanic acid
- Miscellaneous
- Acknowledgment
