Abstract
Background
Albizia zygia (DC.) J.F. Macbr. (Leguminosae) has been used to treat mental disorders in traditional African medicine. Nonetheless, there is limited scientific evidence to justify its present use. The aim of this study was to evaluate the antidepressant activity of the hydroethanolic extract of A. zygia roots (AZE) in murine models.
Methods
AZE was evaluated in the tail suspension test, forced swim test, and the repeated open-space swim test of depression. In order to elucidate the mechanisms of action, the activity of AZE was re-evaluated after treating mice with selective inhibitors of monoamine biosynthesis. The potential of AZE to influence spontaneous locomotion was also examined.
Results
AZE (100–1000 mg/kg, p.o.) reduced the immobility time of mice in the tail suspension and forced swim tests (at least p < 0.05). In the repeated open-space swim test, AZE reduced the immobility time (at least p < 0.05) while concomitantly increasing the distance swam by mice (p < 0.01). However, the antidepressant-like activity of AZE was attenuated by α-methyl-para-tyrosine and reserpine (p < 0.0001) but not para-chlorophenylalanine.
Conclusions
The results of this study indicate that AZE possesses antidepressant-like properties and support the traditional use of AZE for the treatment of depression.
Acknowledgement
We thank the following technical staff of the Department of Pharmacology: Dr. Felix Amissah, Prof. Seth Ablordeppey, Adwoa Abrafi Antwi, Abel Biirbaare Daartey, Albert Doryumu, Godfred Afrifa Antwi, Mohammed Sani Alhassan, and Kofi Opoku Appiah.
- Research funding: None. 
- Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission. 
- Competing interests: The authors declare no conflict of interest. 
- Ethical approval: Ethical approval for the study was granted by the Department of Pharmacology Ethics Committee, KNUST. 
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Review
- Phytochemical profile and pharmacological properties of Trifolium repens
- Original Articles
- Bacopa monnieri alleviates aluminium chloride-induced anxiety by regulating plasma corticosterone level in Wistar rats
- Antidepressant-like effect of Albizia zygia root extract in murine models
- A study of serum cortisol levels in acute head injury patients
- Ferulic acid through mitigation of NMDA receptor pathway exerts anxiolytic-like effect in mouse model of maternal separation stress
- Aberrant pain modulation in trigeminal neuralgia patients
- Phoenix dactylifera Linn fruit based-diets palliate hyperglycemia in alloxan-induced diabetic rats
- Protective effects of Vitex pseudo-negundo leaves on diabetic-induced nephropathy in rats
- Ameliorative effect of Neera, nonfermented coconut inflorescence sap, on cisplatin-induced renal toxicity by abating oxidative stress
- The effect of Rheum ribes L. on oxidative stress in diabetic rats
- Effects of honey supplementation on renal dysfunction and metabolic acidosis in rats with high-fat diet-induced chronic kidney disease
- Co-administration of prazosin and propranolol with glibenclamide improves anti-oxidant defense system in endothelial tissue of streptozotocin-induced diabetic Wistar rats
- Calcium and s100a1 protein balance in the brain–heart axis in diabetic male Wistar rats
- Evaluation of efficacy of Aloe vera (L.) Burm. f. gel solution in methylcellulose-induced ocular hypertension in New Zealand white rabbits
- Haematoprotective and red blood cell membrane stabilizing effects of Justicia carnae leaf extracts in sodium nitrate-treated rats
- Leaf and root bark extracts of Ziziphus abyssinica Hochst ex. A. Rich (Rhamnaceae) ameliorate hepatic, renal and splenic injuries induced by phenylhydrazine in rats
- Antinociceptive, anti-inflammatory and antioxidant effects of Boerhavia coccinea extracts and fractions on acute and persistent inflammatory pain models
- Case Report
- Atorvastatin-linked rhabdomyolysis caused by the simultaneous intake of amoxicillin clavulanic acid
- Miscellaneous
- Acknowledgment
Artikel in diesem Heft
- Review
- Phytochemical profile and pharmacological properties of Trifolium repens
- Original Articles
- Bacopa monnieri alleviates aluminium chloride-induced anxiety by regulating plasma corticosterone level in Wistar rats
- Antidepressant-like effect of Albizia zygia root extract in murine models
- A study of serum cortisol levels in acute head injury patients
- Ferulic acid through mitigation of NMDA receptor pathway exerts anxiolytic-like effect in mouse model of maternal separation stress
- Aberrant pain modulation in trigeminal neuralgia patients
- Phoenix dactylifera Linn fruit based-diets palliate hyperglycemia in alloxan-induced diabetic rats
- Protective effects of Vitex pseudo-negundo leaves on diabetic-induced nephropathy in rats
- Ameliorative effect of Neera, nonfermented coconut inflorescence sap, on cisplatin-induced renal toxicity by abating oxidative stress
- The effect of Rheum ribes L. on oxidative stress in diabetic rats
- Effects of honey supplementation on renal dysfunction and metabolic acidosis in rats with high-fat diet-induced chronic kidney disease
- Co-administration of prazosin and propranolol with glibenclamide improves anti-oxidant defense system in endothelial tissue of streptozotocin-induced diabetic Wistar rats
- Calcium and s100a1 protein balance in the brain–heart axis in diabetic male Wistar rats
- Evaluation of efficacy of Aloe vera (L.) Burm. f. gel solution in methylcellulose-induced ocular hypertension in New Zealand white rabbits
- Haematoprotective and red blood cell membrane stabilizing effects of Justicia carnae leaf extracts in sodium nitrate-treated rats
- Leaf and root bark extracts of Ziziphus abyssinica Hochst ex. A. Rich (Rhamnaceae) ameliorate hepatic, renal and splenic injuries induced by phenylhydrazine in rats
- Antinociceptive, anti-inflammatory and antioxidant effects of Boerhavia coccinea extracts and fractions on acute and persistent inflammatory pain models
- Case Report
- Atorvastatin-linked rhabdomyolysis caused by the simultaneous intake of amoxicillin clavulanic acid
- Miscellaneous
- Acknowledgment