Evaluation of hematological alterations after therapeutic use of dipyrone in healthy adults: a prospective study
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Ernane C. de Souza
Abstract
Background
Dipyrone is a non-narcotic analgesic/antipyretic widely used in some countries but prohibited in others due to suspected risk of agranulocytosis. The primary goal of this study was to evaluate hematological alterations in healthy adult volunteers after treatment with dipyrone.
Methods
The study enrolled 30 healthy volunteers of both genders, aged 19–37 years. They received tablets containing 500 mg of dipyrone sodium to be used four times daily for 7 consecutive days. Before the first administration, arterial pressure was measured and blood was collected in order to evaluate hematological baseline parameters. On the 8th day after the beginning of treatment, the volunteers had their blood pressure assessed once more and underwent a second blood draw. Total and specific leukocyte counts, creatinine, urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), erythrocytes, and platelets were quantitatively determined.
Results
No statistically significant difference was observed among total or specific leukocyte counts. Number of platelets, erythrocytes, hemoglobin, and hematocrit decreased after treatment. Diastolic pressure, mean arterial pressure (MAP), and urea concentration declined, while creatinine, AST, and ALT showed no significant alterations. It is noteworthy that, even for parameters that showed statistically significant changes, the highest and lowest values remained within the normal ranges.
Conclusions
Although dipyrone has historically been associated with agranulocytosis, leukocyte counts remained practically unchanged after oral administration of dipyrone. On the other hand, the present study adds evidence that dipyrone is able to produce statistically relevant decrease in number of platelets, erythrocytes, hemoglobin, and hematocrit in healthy adults, even after short-term treatment.
Author contributions: All authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This work was supported by the Federal University of Juiz de Fora.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Letter to the Editor
- Blister-packed levothyroxine sodium or bottle-packed levothyroxine sodium
- Metabolism
- Comparative hypoglycemic potentials and phytochemical profiles of 12 common leafy culinary vegetables consumed in Nsukka, Southeastern Nigeria
- Infection
- The effects of oral pregabalin on post-Lichtenstein herniorrhaphic pain: a randomized clinical trial
- Cardiovascular Function
- Influence of age and gender on blood pressure variability and baroreflex sensitivity in a healthy population in the Indian sub-continent
- Autonomic responses during acute myocardial infarction in the rat model: implications for arrhythmogenesis
- Phytotherapy
- Role of reactive oxygen species–total antioxidant capacity status in Telfairia occidentalis leaves–associated spermatoprotective effect: a pointer to fatty acids benefit
- Antidiabetic and renoprotective effect of Anogeissus acuminata leaf extract on experimentally induced diabetic nephropathy
- Oxidative Stress
- Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats
- Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats
- Hematological Profile
- Evaluation of hematological alterations after therapeutic use of dipyrone in healthy adults: a prospective study
- Hematology and erythrocyte osmotic fragility of the Franquet’s fruit bat (Epomops franqueti)
- Behavior and Neuroprotection
- Haloperidol-induced parkinsonism is attenuated by varenicline in mice
- Antioxidant-mediated neuroprotection by Allium schoenoprasum L. leaf extract against ischemia reperfusion-induced cerebral injury in mice
- Effects of acetone extract of Cola nitida on brain sodium-potassium adenosine triphosphatase activity and spatial memory in healthy and streptozotocin-induced diabetic female Wistar rats
- Case Report
- Conservative treatment of postoperative chylothorax: a case report
- Short Communication
- Improved serotonergic neurotransmission by genistein pretreatment regulates symptoms of obsessive-compulsive disorder in streptozotocin-induced diabetic mice
Artikel in diesem Heft
- Frontmatter
- Letter to the Editor
- Blister-packed levothyroxine sodium or bottle-packed levothyroxine sodium
- Metabolism
- Comparative hypoglycemic potentials and phytochemical profiles of 12 common leafy culinary vegetables consumed in Nsukka, Southeastern Nigeria
- Infection
- The effects of oral pregabalin on post-Lichtenstein herniorrhaphic pain: a randomized clinical trial
- Cardiovascular Function
- Influence of age and gender on blood pressure variability and baroreflex sensitivity in a healthy population in the Indian sub-continent
- Autonomic responses during acute myocardial infarction in the rat model: implications for arrhythmogenesis
- Phytotherapy
- Role of reactive oxygen species–total antioxidant capacity status in Telfairia occidentalis leaves–associated spermatoprotective effect: a pointer to fatty acids benefit
- Antidiabetic and renoprotective effect of Anogeissus acuminata leaf extract on experimentally induced diabetic nephropathy
- Oxidative Stress
- Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats
- Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats
- Hematological Profile
- Evaluation of hematological alterations after therapeutic use of dipyrone in healthy adults: a prospective study
- Hematology and erythrocyte osmotic fragility of the Franquet’s fruit bat (Epomops franqueti)
- Behavior and Neuroprotection
- Haloperidol-induced parkinsonism is attenuated by varenicline in mice
- Antioxidant-mediated neuroprotection by Allium schoenoprasum L. leaf extract against ischemia reperfusion-induced cerebral injury in mice
- Effects of acetone extract of Cola nitida on brain sodium-potassium adenosine triphosphatase activity and spatial memory in healthy and streptozotocin-induced diabetic female Wistar rats
- Case Report
- Conservative treatment of postoperative chylothorax: a case report
- Short Communication
- Improved serotonergic neurotransmission by genistein pretreatment regulates symptoms of obsessive-compulsive disorder in streptozotocin-induced diabetic mice
