Startseite Medizin Protective effect of Moringa oleifera oil against HgCl2-induced hepato- and nephro-toxicity in rats
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Protective effect of Moringa oleifera oil against HgCl2-induced hepato- and nephro-toxicity in rats

  • Sunny O. Abarikwu EMAIL logo , Sussan Benjamin , Sunday Godspower Ebah , Godbless Obilor und Goodluck Agbam
Veröffentlicht/Copyright: 15. März 2017
Journal of Basic and Clinical Physiology and Pharmacology
Aus der Zeitschrift Journal of Basic and Clinical Physiology and Pharmacology Band 28 Heft 4

Abstract:

Background:

Various parts of the Moringa oleifera (M. oleifera) tree are widely accepted to have ameliorative effects against metal toxicity. In the present study, M. oleifeira oil (MO) was tested against HgCl2-induced tissue pathologies and oxidative stress.

Methods:

Male Wistar rats were administered MO (1.798 mg/kg p.o.) or HgCl2 (5 mg/kg body wt) alone or in combination (5 mg/kg HgCl2+1.798 mg/kg MO p.o.) three times per week for 21 days. After exposure and treatment periods, rats were sacrificed; blood collected and the oxidative status of the liver and kidney homogenates were evaluated.

Results:

In the liver, malondialdehyde (MDA) level, glutathione (GSH), and superoxide dismutase (SOD) activities were higher whereas catalase (CAT) activity was lower in the HgCl2 group than in the control group. In the kidney, MDA level, SOD, and CAT activities were higher whereas GSH activity was unchanged in the HgCl2 group compared to the control group. In the liver, MDA level, SOD, and CAT activities were lower in the HgCl2+MO group than in the HgCl2 group. In the kidney, MDA level, SOD and CAT activities were lower in the HgCl2+MO than in the HgCl2 group. Furthermore, Hg-induced increases in creatinine and bilirubin levels as well as the increase in γ-glutamyl transferase, lactate dehydrogenase, and alkaline phosphatase activities were attenuated in the combine exposure group and the animals showed improvement in the histology of the liver and kidney.

Conclusions:

MO decreased the negative effects of Hg-induced oxidative stress in rats.

Keywords: kidney; liver; mercury chloride; Moringa oleifeira oil (MO); oxidative stress
Corresponding author: Sunny O. Abarikwu, PhD, Department of Biochemistry, Faculty of Science, University of Port Harcourt, Choba, Nigeria, Phone: +234-8030505464, +234-8161346531, Fax: +234-84230903, E-mail:

Acknowledgments

The technical expertise of Messrs Christian Kingsley Nwaugha (Department of Biochemistry, University of Port Harcourt) on animal handling and collection of blood samples is gratefully acknowledged.

  1. Author contributions: S.O.A conceived the study, designed the experiments, and wrote the manuscript. S.B., S.G.E, G.O., and G.A. performed the experiments. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-3-8
Accepted: 2017-1-24
Published Online: 2017-3-15
Published in Print: 2017-7-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. The double face of light effects: circadian adjustment or disruption
  4. Review
  5. Artificial light-at-night – a novel lifestyle risk factor for metabolic disorder and cancer morbidity
  6. Behavior and Neuroprotection
  7. Anti-stress effects of a GSK-3β inhibitor, AR-A014418, in immobilization stress of variable duration in mice
  8. Cardiovascular Function
  9. Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combined dyslipidemia
  10. Oxidative Stress
  11. Protective effect of Moringa oleifera oil against HgCl2-induced hepato- and nephro-toxicity in rats
  12. Effects of peripherally and centrally applied ghrelin on the oxidative stress induced by renin angiotensin system in a rat model of renovascular hypertension
  13. Investigation of the role of α-lipoic acid on fatty acids profile, some minerals (zinc, copper, iron) and antioxidant activity against aluminum-induced oxidative stress in the liver of male rats
  14. Metabolism
  15. The choice of freely preferred cadence by trained nonprofessional cyclists may not be characterized by mechanical efficiency
  16. Immune Response
  17. Ascorbic acid does not modulate potassium currents in cultured human lymphocytes
  18. Phytotherapy
  19. Anti-inflammatory activity of Elaeagnus angustifolia fruit extract on rat paw edema
  20. Histopathological and biochemical assessments of Costus afer stem on alloxan-induced diabetic rats
  21. In vitro inhibition of phosphodiesterase-5 and arginase activities from rat penile tissue by two Nigerian herbs (Hunteria umbellata and Anogeissus leiocarpus)
  22. Antioxidant and antiproliferative potentials of methanol extract of Xylopia aethiopica (Dunal) A. Rich in PC-3 and LNCaP cells
https://doi.org/10.1515/jbcpp-2016-0033
Schlagwörter für diesen Artikel
kidney; liver; mercury chloride; Moringa oleifeira oil (MO); oxidative stress

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. The double face of light effects: circadian adjustment or disruption
  4. Review
  5. Artificial light-at-night – a novel lifestyle risk factor for metabolic disorder and cancer morbidity
  6. Behavior and Neuroprotection
  7. Anti-stress effects of a GSK-3β inhibitor, AR-A014418, in immobilization stress of variable duration in mice
  8. Cardiovascular Function
  9. Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combined dyslipidemia
  10. Oxidative Stress
  11. Protective effect of Moringa oleifera oil against HgCl2-induced hepato- and nephro-toxicity in rats
  12. Effects of peripherally and centrally applied ghrelin on the oxidative stress induced by renin angiotensin system in a rat model of renovascular hypertension
  13. Investigation of the role of α-lipoic acid on fatty acids profile, some minerals (zinc, copper, iron) and antioxidant activity against aluminum-induced oxidative stress in the liver of male rats
  14. Metabolism
  15. The choice of freely preferred cadence by trained nonprofessional cyclists may not be characterized by mechanical efficiency
  16. Immune Response
  17. Ascorbic acid does not modulate potassium currents in cultured human lymphocytes
  18. Phytotherapy
  19. Anti-inflammatory activity of Elaeagnus angustifolia fruit extract on rat paw edema
  20. Histopathological and biochemical assessments of Costus afer stem on alloxan-induced diabetic rats
  21. In vitro inhibition of phosphodiesterase-5 and arginase activities from rat penile tissue by two Nigerian herbs (Hunteria umbellata and Anogeissus leiocarpus)
  22. Antioxidant and antiproliferative potentials of methanol extract of Xylopia aethiopica (Dunal) A. Rich in PC-3 and LNCaP cells
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