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Galectins: new agonists of platelet activation

  • Mirta Schattner EMAIL logo und Gabriel A. Rabinovich
Veröffentlicht/Copyright: 18. März 2013

Abstract

Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article, we review recent advances in knowledge of the role of galectins in platelet physiology. In soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through the modulation of discrete signaling pathways. We discuss the role of platelet–galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.


Corresponding author: Mirta Schattner, Laboratory of Experimental Thrombosis, Institute of Experimental Medicine (IMEX/CONICET), National Academy of Medicine, C1425, Buenos Aires, Argentina

Work in M.S.’s and G.A.R.’s laboratories is supported by grants from the National Agency for Promotion of Science and Technology (Argentina) and National Council for Scientific and Technical Investigation (CONICET, Argentina). Work in G.A.R.’s lab is supported by the Sales Foundation for Cancer (Argentina), University of Buenos Aires (Argentina), and National Multiple Sclerosis Society (USA).

References

Al-Ansari, S., Zeebregts, C.J., Slart, R.H., Peppelenbosch, M., and Tio, R.A. (2009). Galectins in atherosclerotic disease. Trends. Cardiovasc. Med. 19, 164–169.10.1016/j.tcm.2009.10.001Suche in Google Scholar PubMed

Angiolillo DJ, Ueno M, Goto S. (2010). Basic principles of platelet biology and clinical implications. Circ. J. 74, 597–607.10.1253/circj.CJ-09-0982Suche in Google Scholar PubMed

Bidon-Wagner, N. and Le Pennec, J.P. (2004). Human galectin-8 isoforms and cancer. Glycoconj. J. 19, 557–563.10.1023/B:GLYC.0000014086.38343.98Suche in Google Scholar PubMed

Cattaneo, V., Tribulatti, M.V., and Campetella, O. (2011). Galectin-8 tandem-repeat structure is essential for T-cell proliferation but not for co-stimulation. Biochem J. 434, 153–160.10.1042/BJ20101691Suche in Google Scholar PubMed

Davicino, R.C., Eliçabe, R.J., Di Genaro, M.S., and Rabinovich, G.A. (2011). Coupling pathogen recognition to innate immunity through glycan-dependent mechanisms. Int. Immunopharmacol. 11, 1457–1463.10.1016/j.intimp.2011.05.002Suche in Google Scholar PubMed

Di Lella, S., Sundblad, V., Cerliani, J.P., Guardia, C.M., Estrin, D.A., Vasta, G.R., and Rabinovich, G.A. (2011). When galectins recognize glycans: from biochemistry to physiology and back again. Biochemistry 50, 7842–7857.10.1021/bi201121mSuche in Google Scholar PubMed PubMed Central

Dotsenko, O., Chaturvedi, N., Thom, S.A., Wright, A.R., Mayet, J., Shore, A., Schalkwijk, C., and Hughes, A.D. (2007). Platelet and leukocyte activation, atherosclerosis and inflammation in European and South Asian men. J. Thromb. Haemost. 5, 2036–2042.10.1111/j.1538-7836.2007.02711.xSuche in Google Scholar PubMed PubMed Central

Etulain, J.S.M. (2012). Current viewpoints on platelet contribution to inflammation. World J. Hematol. 1, 14–21.10.5315/wjh.v1.i4.14Suche in Google Scholar

Leslie, M. (2010). Cell biology. Beyond clotting: the powers of platelets. Science 328, 562–564.10.1126/science.328.5978.562Suche in Google Scholar PubMed

Liu, F.T. and Rabinovich, G.A. (2005). Galectins as modulators of tumour progression. Nat. Rev. Cancer 5, 29–41.10.1038/nrc1527Suche in Google Scholar PubMed

Liu, F.T. and Rabinovich, G.A. (2010). Galectins: regulators of acute and chronic inflammation. Ann. N. Y. Acad. Sci. 1183, 158–182.10.1111/j.1749-6632.2009.05131.xSuche in Google Scholar PubMed

Luo, G.P., Ni, B., Yang, X., and Wu, Y.Z. (2012). von Willebrand factor: more than a regulator of hemostasis and thrombosis. Acta. Haematol. 128, 158–169.10.1159/000339426Suche in Google Scholar PubMed

Ma, Y.Q., Qin, J., and Plow, E.F. (2007). Platelet integrin alpha(IIb)beta(3): activation mechanisms. J. Thromb. Haemost. 5, 1345–1352.10.1111/j.1538-7836.2007.02537.xSuche in Google Scholar PubMed

May, A.E., Seizer, P., and Gawaz, M. (2008). Platelets: inflammatory firebugs of vascular walls. Arterioscler. Thromb. Vasc. Biol. 28, s5–10.10.1161/ATVBAHA.107.158915Suche in Google Scholar PubMed

Morel, O., Toti, F., Hugel, B., Bakouboula, B., Camoin-Jau, L., Dignat-George, F., and Freyssinet, J.M. (2006). Procoagulant microparticles: disrupting the vascular homeostasis equation? Arterioscler. Thromb. Vasc. Biol. 26, 2594–2604.10.1161/01.ATV.0000246775.14471.26Suche in Google Scholar PubMed

Nurden, A.T., Nurden, P., Sanchez, M., Andia, I., and Anitua, E. (2008). Platelets and wound healing. Front. Biosci. 13, 3532–3548.10.2741/2947Suche in Google Scholar PubMed

Ozaki, Y., Asazuma, N., Suzuki-Inoue, K., and Berndt, M.C. (2005). Platelet GPIb-IX-V-dependent signaling. J. Thromb. Haemost. 3, 1745–1751.10.1111/j.1538-7836.2005.01379.xSuche in Google Scholar PubMed

Pacienza, N., Pozner, R.G., Bianco, G.A., D’Atri, L.P., Croci, D.O., Negrotto, S., Malaver, E., Gómez, R.M., Rabinovich, G.A., and Schattner, M. (2008). The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation. Faseb. J. 22, 1113–1123.10.1096/fj.07-9524comSuche in Google Scholar PubMed

Rabinovich, G.A. and Toscano, M.A. (2009). Turning ‘sweet’ on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat. Rev. Immunol. 9, 338–352.10.1038/nri2536Suche in Google Scholar PubMed

Rabinovich, G.A., Toscano, M.A., Jackson, S.S., and Vasta, G.R. (2007). Functions of cell surface galectin-glycoprotein lattices. Curr. Opin. Struct. Biol. 17, 513–520.10.1016/j.sbi.2007.09.002Suche in Google Scholar PubMed PubMed Central

Rivera, J., Lozano, M.L., Navarro-Núñez, L., and Vicente, V. (2009). Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica 94, 700–711.10.3324/haematol.2008.003178Suche in Google Scholar PubMed PubMed Central

Romaniuk, M.A., Tribulatti, M.V., Cattaneo, V., Lapponi, M.J., Molinas, F.C., Campetella, O., and Schattner, M. (2010). Human platelets express and are activated by galectin-8. Biochem J. 432, 535–547.10.1042/BJ20100538Suche in Google Scholar PubMed

Romaniuk, M.A., Negrotto, S., Campetella, O., Rabinovich, G.A., and Schattner, M. (2011). Identification of galectins as novel regulators of platelet signaling and function. IUBMB Life 63, 521–527.10.1002/iub.483Suche in Google Scholar PubMed

Romaniuk, M.A., Croci, D.O., Lapponi, M.J., Tribulatti, M.V., Negrotto, S., Poirier, F., Campetella, O., Rabinovich, G.A., and Schattner, M. (2012). Binding of galectin-1 to alphaIIbbeta(3) integrin triggers “outside-in” signals, stimulates platelet activation, and controls primary hemostasis. Faseb. J. 26, 2788–2798.10.1096/fj.11-197541Suche in Google Scholar PubMed

Saint-Lu, N., Oortwijn, B.D., Pegon, J.N., Odouard, S., Christophe, O.D., de Groot, P.G., Denis, C.V., and Lenting, P.J. (2012). Identification of galectin-1 and galectin-3 as novel partners for von Willebrand factor. Arterioscler. Thromb. Vasc. Biol. 32, 894–901.10.1161/ATVBAHA.111.240309Suche in Google Scholar PubMed

Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L.G., Bakkers, J., et al. (2006). Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc. Natl. Acad. Sci. USA 103, 15975–15980.10.1073/pnas.0603883103Suche in Google Scholar PubMed PubMed Central

Thijssen, V.L., Hulsmans, S., and Griffioen, A.W. (2008). The galectin profile of the endothelium: altered expression and localization in activated and tumor endothelial cells. Am. J. Pathol. 172, 545–553.10.2353/ajpath.2008.070938Suche in Google Scholar PubMed PubMed Central

Torti, M., Festetics, E.T., Bertoni, A., Sinigaglia, F., and Balduini, C. (1999). Clustering of integrin alphaIIb-beta3 differently regulates tyrosine phosphorylation of pp72syk, PLCgamma2 and pp125FAK in concanavalin A-stimulated platelets. Thromb. Haemost. 81, 124–130.10.1055/s-0037-1614429Suche in Google Scholar

Wagner, D.D. (2005). New links between inflammation and thrombosis. Arterioscler. Thromb. Vasc. Biol. 25, 1321–1324.10.1161/01.ATV.0000166521.90532.44Suche in Google Scholar PubMed

Yang, R.Y., Rabinovich, G.A., and Liu, F.T. (2008). Galectins: structure, function and therapeutic potential. Expert. Rev. Mol. Med. 10, e17.10.1017/S1462399408000719Suche in Google Scholar PubMed

Zappelli, C., van der Zwaan, C., Thijssen-Timmer, D.C., Mertens, K., and Meijer, A.B. (2012). Novel role for galectin-8 protein as mediator of coagulation factor V endocytosis by megakaryocytes. J. Biol. Chem. 287, 8327–8335.10.1074/jbc.M111.305151Suche in Google Scholar PubMed PubMed Central

Received: 2013-1-11
Accepted: 2013-3-14
Published Online: 2013-3-18
Published in Print: 2013-7-1

©2013 by Walter de Gruyter Berlin Boston

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