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Platelet function and thymosin β4
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Harmanpreet Kaur
Veröffentlicht/Copyright:
1. Juli 2012
Abstract
Thymosin β4 (Tβ4) is a small, low-molecular-weight peptide ubiquitously expressed in all cells and extracellular fluids. It is a major actin sequestering protein present in the cells. In addition to this, Tβ4 has also been shown to be involved in endothelial cell migration, angiogenesis, corneal wound healing, and stem cell differentiation. It is also released by platelets after activation. The amount of Tβ4 increases at sites of injury and thus suggests an important role of this biopeptide in wound healing. Herein, we provide an overview of the role of Tβ4 in thrombosis and platelet aggregation.
Received: 2012-2-25
Accepted: 2012-3-29
Published Online: 2012-07-01
Published in Print: 2012-07-01
©2012 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
actin;
fibrinogen;
platelet aggregation;
platelet receptors;
thrombosis;
transglutaminase
Artikel in diesem Heft
- Masthead
- Masthead
- Reviews
- Mitophagy: mechanisms, pathophysiological roles, and analysis
- Zinc networks: the cell-specific compartmentalization of zinc for specialized functions
- Cyclophilin involvement in the replication of hepatitis C virus and other viruses
- Minireviews
- TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration
- Platelet function and thymosin β4
- Exportin T and Exportin 5: tRNA and miRNA biogenesis – and beyond
- Genes and Nucleic Acids
- Biological and molecular analysis of the pathogenic variant C3 of potato spindle tuber viroid (PSTVd) evolved during adaptation to chamomile (Matricaria chamomilla)
- Protein Structure and Function
- Heterologous production and functional and thermodynamic characterization of cation diffusion facilitator (CDF) transporters of mesophilic and hyperthermophilic origin
- Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates
- Antimicrobial activity of human islet amyloid polypeptides: an insight into amyloid peptides’ connection with antimicrobial peptides
- Cell Biology and Signaling
- Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine
