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Antimicrobial activity of human islet amyloid polypeptides: an insight into amyloid peptides’ connection with antimicrobial peptides
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Lan Wang
Published/Copyright:
July 1, 2012
Abstract
Human islet amyloid polypeptide (hIAPP) shows an antimicrobial activity towards two types of clinically relevant bacteria. The potency of hIAPP varies with its aggregation states. Circular dichroism was employed to determine the interaction between hIAPP and bacteria lipid membrane mimic. The antimicrobial activity of each aggregate species is associated with their ability to induce membrane disruption. Our findings provide new evidence revealing the antimicrobial activity of amyloid peptide, which suggest a possible connection between amyloid peptides and antimicrobial peptides.
Received: 2012-1-21
Accepted: 2012-4-16
Published Online: 2012-07-01
Published in Print: 2012-07-01
©2012 by Walter de Gruyter Berlin Boston
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