Startseite The impact of admission neutrophil-to-platelet ratio on in-hospital and long-term mortality in patients with infective endocarditis
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The impact of admission neutrophil-to-platelet ratio on in-hospital and long-term mortality in patients with infective endocarditis

  • Xue-biao Wei , Yuan-hui Liu , Peng-cheng He EMAIL logo , Dan-qing Yu EMAIL logo , Ning Tan , Ying-ling Zhou und Ji-yan Chen
Veröffentlicht/Copyright: 17. Dezember 2016
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Clinical Chemistry and Laboratory Medicine (CCLM)
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine (CCLM) Band 55 Heft 6

Abstract

Background:

Infective endocarditis (IE) is associated with increased neutrophil and reduced platelet counts. We assessed the relationship between the neutrophil-to-platelet ratio (NPR) on admission and adverse outcomes in patients with IE.

Methods:

Patients diagnosed with IE between January 2009 and July 2015 (n=1293) were enrolled, and 1046 were finally entered into the study. Study subjects were categorized into four groups according to NPR quartiles: Q1<18.9 (n=260); Q2: 18.9–27.7 (n=258); Q3: 27.7–43.3 (n=266); and Q4>43.3 (n=262). Cox proportional hazards regression was performed to identify risk factors for long-term mortality; the optimal cut-off was evaluated by receiver operating characteristic curves.

Results:

Risk of in-hospital death increased progressively with NPR group number (1.9 vs. 5.0 vs. 9.8 vs. 14.1%, p<0.001). The follow-up period was a median of 28.8 months, during which 144 subjects (14.3%) died. Long-term mortality increased from the lowest to the highest NPR quartiles (7.6, 11.8, 17.4, and 26.2%, respectively, p<0.001). Multivariate Cox proportional hazard analysis revealed that lgNPR (HR=2.22) was an independent predictor of long-term mortality. Kaplan-Meier survival curves showed that subjects in Q4 had an increased long-term mortality compared with the other groups.

Conclusions:

Increased NPR was associated with in-hospital and long-term mortality in patients with IE. As a simple and inexpensive index, NPR may be a useful and rapid screening tool to identify IE patients at high risk of mortality.

Keywords: infective endocarditis; neutrophil; outcome; platelet
Corresponding authors: Peng-cheng He, MD, PhD and Dan-qing Yu, MD, PhD, Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academic of Medical Sciences, Guangzhou 510080, Guangdong, P.R. China, Phone: 020-83827812, Fax: 020-83827812
aXue-biao Wei and Yuan-hui Liu are considered as co-first authors.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Conflict of interest: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-6-16
Accepted: 2016-10-31
Published Online: 2016-12-17
Published in Print: 2017-6-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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  2. Editorial
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  23. Cardiovascular Diseases
  24. The impact of admission neutrophil-to-platelet ratio on in-hospital and long-term mortality in patients with infective endocarditis
  25. Letters to the Editor
  26. Biotin interference in immunoassays mimicking subclinical Graves’ disease and hyperestrogenism: a case series
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  28. Proposed classification for a variant of Kounis syndrome
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  33. Immunoassay interference caused by heterophilic antibodies interacting with biotin
  34. Red blood cell distribution width and mean platelet volume are potential prognostic indices for patients with primary biliary cirrhosis
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https://doi.org/10.1515/cclm-2016-0527
Schlagwörter für diesen Artikel
infective endocarditis; neutrophil; outcome; platelet

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Biotin interference on immunoassay methods: sporadic cases or hidden epidemic?
  4. Reviews
  5. False biochemical diagnosis of hyperthyroidism in streptavidin-biotin-based immunoassays: the problem of biotin intake and related interferences
  6. Vitamin K plasma levels determination in human health
  7. Mini Review
  8. Point-of-care testing INR: an overview
  9. Opinion Paper
  10. Could accreditation bodies facilitate the implementation of medical guidelines in laboratories?
  11. Genetics and Molecular Diagnostics
  12. QMPSF is sensitive and specific in the detection of NPHP1 heterozygous deletions
  13. General Clinical Chemistry and Laboratory Medicine
  14. High-dose biotin therapy leading to false biochemical endocrine profiles: validation of a simple method to overcome biotin interference
  15. Multicenter performance evaluation of a second generation cortisol assay
  16. A rapid UPLC-MS/MS assay for the simultaneous measurement of fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole concentrations in serum
  17. A microplate assay to measure classical and alternative complement activity
  18. Serological diagnosis and prognosis of severe acute pancreatitis by analysis of serum glycoprotein 2
  19. Retrospective evaluation of the clinical utility of serological biomarkers in Chinese patients with inflammatory bowel disease: 2-year clinical experience
  20. Infrared analysis of lipoproteins in the detection of alcohol biomarkers
  21. Coexistence of anti-β2-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies suggests strong thrombotic risk
  22. Antiphosphatidylserine/prothrombin antibodies as biomarkers to identify severe primary antiphospholipid syndrome
  23. Cardiovascular Diseases
  24. The impact of admission neutrophil-to-platelet ratio on in-hospital and long-term mortality in patients with infective endocarditis
  25. Letters to the Editor
  26. Biotin interference in immunoassays mimicking subclinical Graves’ disease and hyperestrogenism: a case series
  27. A simple method to detect biotin interference on immunoassays
  28. Proposed classification for a variant of Kounis syndrome
  29. Lyophilized hemoglobin E control material for the dichlorophenol-indophenol (DCIP) test
  30. Procalcitonin variation before and after 100-km ultramarathon
  31. Preliminary study in specific activity of molecular components in allergy: implications for diagnostics and relationship with disease severity
  32. A 2-min at 4500 g rather than a 15-min at 2200 g centrifugation does not impact the reliability of 10 critical coagulation assays
  33. Immunoassay interference caused by heterophilic antibodies interacting with biotin
  34. Red blood cell distribution width and mean platelet volume are potential prognostic indices for patients with primary biliary cirrhosis
  35. Neutrophil CD64 molecule expression can predict bloodstream infection in septic shock patients
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