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Evaluation of a new method for the diagnosis of alterations of Lens culinaris agglutinin binding of thyroglobulin molecules in thyroid carcinoma
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Toshiharu Kanai
Veröffentlicht/Copyright:
11. September 2009
Abstract
Background: The measurement of serum thyroglobulin (Tg) is widely used as a marker for recurrence of thyroid carcinoma following total thyroidectomy. However, this method cannot differentiate between benign and malignant disease. We focused on the sugar chain in the Tg molecule and investigated the usefulness of Lens culinaris agglutinin (LCA)-reactive Tg ratios in sera and wash fluids obtained during fine-needle aspiration (FNA) for the detection of thyroid carcinoma.
Methods: The study was performed using 203 serum samples (115 from patients with benign thyroid disease and 88 from patients with thyroid carcinomas) and 176 wash fluid samples (143 benign, 21 malignant, and 12 inconclusive). LCA-reactive Tg ratios were determined using an enzyme-linked immunosorbent assay, and a comparison was made between malignant and benign lesions.
Results: In serum, the ratio in patients with malignancy was 79.5±6.0 [mean±standard deviation (SD)], significantly lower than in patients with benign lesions (84.9±3.5). The ratios in wash fluid from malignant lesions (75.8±18.9) were also significantly lower than those from benign lesions (85.6±3.9).
Conclusions: These results suggest that this method could distinguish between benign and malignant lesions and may be useful for screening serum and wash samples.
Clin Chem Lab Med 2009;47:1285–90.
Received: 2009-4-20
Accepted: 2009-6-30
Published Online: 2009-09-11
Published in Print: 2009-10-01
©2009 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
Lens culinaris agglutinin;
sugar chain;
thyroglobulin;
thyroid carcinoma
Artikel in diesem Heft
- Editorial
- Cardiac troponins: what we knew, what we know – where are we now?
- Review
- Measurement of circulating concentrations of cardiac troponin I and T in healthy subjects: a tool for monitoring myocardial tissue renewal?
- Opinion Papers
- A critical appraisal of experimental factors influencing the definition of the 99th percentile limit for cardiac troponins
- Genetic and biochemical heterogeneity of cardiac troponins: clinical and laboratory implications
- The future of hospital laboratories. Position statement from the Royal Belgian Society of Clinical Chemistry (RBSCC)
- Point
- Quantity quotient reporting. A proposal for a standardized presentation of laboratory results
- Counterpoint
- Quantity quotient reporting. Counterpoint
- Perspectives
- Increasing laboratory medicine activities in China: research and publications
- Contributions in Biochemistry and Molecular Biology from China and other top-ranking countries: a 10-year survey of the literature
- Genetics and Molecular Diagnostics
- SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells
- Polymorphisms of the β1-adrenergic receptor gene are associated with essential hypertension in Chinese
- Egyptian glycogen storage disease type III – identification of six novel AGL mutations, including a large 1.5 kb deletion and a missense mutation p.L620P with subtype IIId
- Novel rare alleles of ABCA1 are exclusively associated with extreme high-density lipoprotein-cholesterol levels among the Han Chinese
- –308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease
- General Clinical Chemistry and Laboratory Medicine
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- HbA1c measurements from dried blood spots: validation and patient satisfaction
- Pre-transplant serum concentrations of anti-endothelial cell antibody in panel reactive antibody negative renal recipients and its impact on acute rejection
- Cancer Diagnostics
- Detection of Meningeosis neoplastica by real-time quantitation of telomerase activity
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- Abstracts
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