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Tumor necrosis factor-α and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions
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Mohamed El-Far
Veröffentlicht/Copyright:
8. Juli 2007
Abstract
Background: Many factors have been implicated in the pathogenesis of unexplained recurrent spontaneous abortion (URSA). The current study was conducted to determine the possible role of antioxidant status and tumor necrosis factor-α (TNF-α) in URSA.
Methods: Reduced glutathione (GSH), glutathione reductase (GSH-R), glutathione peroxidase (GSH-PX), catalase (CAT), superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA) and TNF-α were assayed in women suffering unexplained first-trimester abortions. Two groups were included, the first represented by 24 women with URSA (number of abortions 3–5) and the second included 16 women with URSA (number of abortions >5). The control group included 20 women within their first trimester of pregnancy and 20 non-pregnant healthy females within their follicular phase.
Results: We observed that the antioxidant levels measured were significantly lower in URSA groups than in the control group (p<0.05 for each comparison). Higher TNF-α, MDA and NO production were detected in URSA groups compared to controls (p<0.05 for each comparison). URSA 3–5 was associated with significantly higher levels of antioxidants and lower levels of TNF-α compared to levels in URSA >5.
Conclusions: Impaired antioxidant defense and an increase in oxidative reactive species may be responsible for recurrent abortion due to possible damage produced by their generation. In addition, the level of TNF-α apparently contributes to the pathogenesis of URSA.
Clin Chem Lab Med 2007;45:879–83.
Keywords: antioxidant; free radicals; miscarriage; tumor necrosis factor-α; unexplained recurrent spontaneous abortion
Received: 2007-1-23
Accepted: 2007-3-5
Published Online: 2007-07-08
Published in Print: 2007-07-01
©2007 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
antioxidant;
free radicals;
miscarriage;
tumor necrosis factor-α;
unexplained recurrent spontaneous abortion
Artikel in diesem Heft
- Pharmacogenomics and Personalized Medicine – a global reality check
- Pharmacogenomics and adverse drug reactions in diagnostic and clinical practice
- Impact of genetic polymorphisms on the risk of lipid disorders in patients on anti-HIV therapy
- Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer
- Effect of 13-cis-retinoic acid on the genetic expression profile of human umbilical vein endothelial cells (HUVECs) determined by microarray
- Association between T102C and A–1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs
- A1166C polymorphism of the angiotensin AT1 receptor (AT1R) gene alters endothelial response to statin treatment
- Third Santorini conference pharmacogenomics workshop report: “Pharmacogenomics at the crossroads: what else than good science will be needed for the field to become part of Personalized Medicine?”
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