Analysis of glomerular filtration rate, serum cystatin C levels, and renal resistive index values in cirrhosis patients
-
Abstract
Background: The aim of this study was to evaluate the relation of glomerular filtration rate (GFR) to serum cystatin C levels, renal resistive index (RRI), serum creatinine and creatinine clearance in patients with different stages of cirrhosis.
Methods: The study sample was 25 cirrhotic patients (10 females and 15 males; mean age 57.3±2.04 years), 10 in the compensated stage without ascites and 15 in the decompensated stage with new-onset ascites. None had azotemia nor were on diuretic treatment. The control group comprised 25 healthy adults (11 female and 14 men; mean age 56.56±1.91 years). Serum cystatin C, RRI, serum creatinine and creatinine clearance were measured. GFR was determined by technetium99m-diethylene triamine pentaacetic acid renal scintigraphy.
Results: Cirrhosis cases had lower mean scintigraphic GFR than controls (64.5±4.03 vs. 87.96±4.16 mL/min, p<0.05). Serum cystatin C and RRI were significantly higher in the cirrhotic group compared to controls (1.16±0.09 mg/L and 0.68±0.01 vs. 0.86±0.03 mg/L and 0.64±0.01, respectively; p<0.05). Subgroup comparative analysis showed that only two parameters, scintigraphic GFR and serum cystatin C, were significantly different between compensated and decompensated cirrhotics (75.62±4.9 mL/min and 0.89±0.07 mg/L vs. 57.23±5.14 mL/min and 1.34±0.13mg/L, respectively; p<0.05). Scintigraphic GFR showed significant correlation with cystatin C, but not with serum creatinine or creatinine clearance (r=–0.877, p<0.05) in decompensated patients. No correlation was observed between scintigraphic GFR and RRI or between serum cystatin C and RRI in all subjects. A receiver operator characteristics curve showed that cystatin C at a cutoff value of 1.01 mg/L can significantly differentiate patients with GFR <70 mL/min with 80% sensitivity and 80% specificity.
Conclusions: Serum cystatin C, but not serum creatinine or RRI measurement, correlates with GFR in each stage of liver failure and has a significant diagnostic advantage in detecting lower GFR in such cases.
Clin Chem Lab Med 2007;45:890–4.
©2007 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Pharmacogenomics and Personalized Medicine – a global reality check
- Pharmacogenomics and adverse drug reactions in diagnostic and clinical practice
- Impact of genetic polymorphisms on the risk of lipid disorders in patients on anti-HIV therapy
- Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer
- Effect of 13-cis-retinoic acid on the genetic expression profile of human umbilical vein endothelial cells (HUVECs) determined by microarray
- Association between T102C and A–1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs
- A1166C polymorphism of the angiotensin AT1 receptor (AT1R) gene alters endothelial response to statin treatment
- Third Santorini conference pharmacogenomics workshop report: “Pharmacogenomics at the crossroads: what else than good science will be needed for the field to become part of Personalized Medicine?”
- On detecting interference from endogenous antibodies in immunoassays by doubling dilutions test
- High-sensitivity C-reactive protein concentration in patients with myocardial infarction-environmental factors, and polymorphisms in interleukin-10 and CD14 genes
- Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience
- A novel application of melting curves: utility of peak area calculation for relative methylation quantification
- Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians
- Tumor necrosis factor-α and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions
- Paraoxonase and platelet-activating factor acetylhydrolase activities in lipoproteins of β-thalassemia/hemoglobin E patients
- Analysis of glomerular filtration rate, serum cystatin C levels, and renal resistive index values in cirrhosis patients
- Direct determination of selenium in human serum by inductively coupled plasma-collision cell-mass spectrometry
- Within-subject variation of plasma resistin levels over a 1-year period
- Global DNA methylation measured by liquid chromatography-tandem mass spectrometry: analytical technique, reference values and determinants in healthy subjects
- Values for free/total prostate-specific antigen ratio as a function of age: necessity of reference validation in a Turkish population
- Comparison of the Roche COBAS Amplicor™ Monitor, Roche COBAS Ampliprep™/COBAS Taqman™ and Abbott RealTime™ Test assays for quantification of hepatitis C virus and HIV RNA
- Genetic cystic fibrosis transmembrane regulator 4016insT D1152H compound heterozygosity and male infertility: an Italian case report
- Reference intervals for serum cystatin C in healthy Mexican adults
- Could standard ISO 15189 be useful for the conundrum of CA 19-9/GI Monitor measurement?
- Quality control strategy to verify day-to-day imprecision of length of blood sedimentation reaction measurements with the TEST-1 analyzer
- Applicability of α-fetoprotein-concanavalin A (AFP-ConA) binding to discriminate between germinal or hepatic origin of AFP in germ cell tumour patients during chemotherapy or follow-up
- Proposal of a candidate international conventional reference measurement procedure for free thyroxine in serum
- Balkan Clinical Laboratory Federation − past, present and future trends
Articles in the same Issue
- Pharmacogenomics and Personalized Medicine – a global reality check
- Pharmacogenomics and adverse drug reactions in diagnostic and clinical practice
- Impact of genetic polymorphisms on the risk of lipid disorders in patients on anti-HIV therapy
- Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer
- Effect of 13-cis-retinoic acid on the genetic expression profile of human umbilical vein endothelial cells (HUVECs) determined by microarray
- Association between T102C and A–1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs
- A1166C polymorphism of the angiotensin AT1 receptor (AT1R) gene alters endothelial response to statin treatment
- Third Santorini conference pharmacogenomics workshop report: “Pharmacogenomics at the crossroads: what else than good science will be needed for the field to become part of Personalized Medicine?”
- On detecting interference from endogenous antibodies in immunoassays by doubling dilutions test
- High-sensitivity C-reactive protein concentration in patients with myocardial infarction-environmental factors, and polymorphisms in interleukin-10 and CD14 genes
- Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience
- A novel application of melting curves: utility of peak area calculation for relative methylation quantification
- Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians
- Tumor necrosis factor-α and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions
- Paraoxonase and platelet-activating factor acetylhydrolase activities in lipoproteins of β-thalassemia/hemoglobin E patients
- Analysis of glomerular filtration rate, serum cystatin C levels, and renal resistive index values in cirrhosis patients
- Direct determination of selenium in human serum by inductively coupled plasma-collision cell-mass spectrometry
- Within-subject variation of plasma resistin levels over a 1-year period
- Global DNA methylation measured by liquid chromatography-tandem mass spectrometry: analytical technique, reference values and determinants in healthy subjects
- Values for free/total prostate-specific antigen ratio as a function of age: necessity of reference validation in a Turkish population
- Comparison of the Roche COBAS Amplicor™ Monitor, Roche COBAS Ampliprep™/COBAS Taqman™ and Abbott RealTime™ Test assays for quantification of hepatitis C virus and HIV RNA
- Genetic cystic fibrosis transmembrane regulator 4016insT D1152H compound heterozygosity and male infertility: an Italian case report
- Reference intervals for serum cystatin C in healthy Mexican adults
- Could standard ISO 15189 be useful for the conundrum of CA 19-9/GI Monitor measurement?
- Quality control strategy to verify day-to-day imprecision of length of blood sedimentation reaction measurements with the TEST-1 analyzer
- Applicability of α-fetoprotein-concanavalin A (AFP-ConA) binding to discriminate between germinal or hepatic origin of AFP in germ cell tumour patients during chemotherapy or follow-up
- Proposal of a candidate international conventional reference measurement procedure for free thyroxine in serum
- Balkan Clinical Laboratory Federation − past, present and future trends
