Immunoglobulin G Fcγ receptor expression on polymorphonuclear cells in bronchoalveolar lavage fluid of HIV-infected and HIV-seronegative patients with bacterial pneumonia
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Christine Armbruster
Abstract
This study was designed to test the hypothesis that impaired neutrophil function might contribute to the development of bacterial pneumonia in patients with HIV-infection. Numbers of inflammatory cells and immunoglobulin G Fcγ receptor (IgG FcγR) I, II, III levels were investigated in bronchoalveolar lavage (BAL) fluid of HIV-seronegative and HIV-infected patients with bacterial pneumonia. The 99 patients were classified into three groups: I: HIV-seronegative and pneumonia (n=40); II: HIV-infected and pneumonia (n=19); III: HIV-seronegative with other pulmonary diseases than pneumonia (n=40). The results of groups I and II, II and III, and I and III were compared. The percentage of alveolar macrophages was significantly lower (group II vs. III: p=0.005, group I vs. III: p=0.001), that of neutrophils increased significantly in patients with pneumonia (group II vs. III: p=0.02, group I vs. III: p=0.01). Lymphocytes differed only between groups I and III (p=0.04). Although only the expression of FcγRI was significantly higher in HIV-seronegative pneumonia patients compared to those without pneumonia (p=0.01), the mean expression of all three receptors was lower in the HIV-infected group, with that of FcγRI approaching statistical significance.
This report provides first evidence that altered FcγR expression on BAL neutrophils might contribute to the increased susceptibility of HIV-infected patients to bacterial pneumonia.
Copyright (c) 2004 by Walter de Gruyter GmbH & Co. KG
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- Regulation of inflammatory responses by activated protein C: the molecular mechanism(s) and therapeutic implications
- Increased serum maternal levels of the HER2 oncoprotein p105 ectodomain in preeclampsia
- Determination of urinary glyoxal and methylglyoxal by high-performance liquid chromatography
- Antioxidants in patients with hyperthyroidism
- Biochemical diagnosis of impaired left ventricular ejection fraction - comparison of the diagnostic accuracy of brain natriuretic peptide (BNP) and amino terminal proBNP (NT-proBNP)
- Autoantibodies against oxidized low-density lipoprotein (ox-LDL) and LDL oxidation status
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