Volume 16, Issue 4

It is well-known that chemotherapy is the most significant method on curing the most death-causing disease like cancer. These days, the use of controller-based approach for finding the optimal rate of drug injection throughout the treatment has increased a lot. Under these circumstances, this paper establishes a novel robust controller that influences the drug dosage along with parameter estimation. A new nonlinear error function-based extended Kalman filter (EKF) with improved scaling factor (NEF-EKF-ISF) is introduced in this research work. In fact, in the traditional schemes, the error is computed using the conventional difference function and it is deployed for the updating process of EKF. In our previous work, it has been converted to the nonlinear error function. Here, the updating process is based on the prior error function, though scaled to a nonlinear environment. In addition, a scaling factor is introduced here, which considers the historical error improvement, for the updating process. Finally, the performance of the proposed controller is evaluated over other traditional approaches, which implies the appropriate impact of drug dosage injection on normal, immune and tumor cells. Moreover, it is observed that the proposed NEF-EKF-ISF has the ability to evaluate the tumor cells with a better accuracy rate.

In breast cancer patients, metastasis remains a major cause of death. The metastasis formation process is given by an interaction between the cancer cells and the microenvironment that surrounds them. In this article, we develop a mathematical model that analyzes the role of interleukin IL-17 and its action in promoting cancer and in facilitating tissue metastasis in breast cancer, using a dynamic analysis based on a stochastic process that accounts for the local and global action of this molecule. The model uses the Ornstein–Uhlembeck and Markov process in continuous time. It focuses on the oncological expansion and the interaction between the interleukin IL-17 and cell populations This analysis tends to clarify the processes underlying the metastasis expansion mechanism both for a better understanding of the pathological event and for a possible better control of therapeutic strategies. IL-17 is a proinflammatory interleukin that acts when there is tissue damage or when there is a pathological situation caused by an external pathogen or by a pathological condition such as cancer. This research is focused on the role of interleukin IL-17 which, especially in the case of breast cancer, turns out to be a dominant “communication pin” since it interconnects with the activity of different cell populations affected by the oncological phenomenon. Stochastic modeling strategies, specially the Ornstein-Uhlenbeck process, with the aid of numerical algorithms are elaborated in this review. The role of IL-17 is discussed in this manuscript at all the stages of cancer. It is discussed that IL-17 also acts as “metastasis promoter” as a result of its proinflammatory nature. The stochastic nature of IL-17 is discussed based on the evidence provided by recent literature. The resulting dynamical analysis can help to select the most appropriate therapeutic strategy. Cancer cells, in the case of breast cancer, have high level of IL-17 receptors (IL-17R); therefore the interleukin itself has direct effects on these cells. Immunotherapy research, focused on this cytokine and interlinked with the stochastic modeling, seems to be a promising avenue.

Objectives The Electroencephalogram (EEG) signal is modified using the Motor Imagery (MI) and it is utilized for patients with high motor impairments. Hence, the direct relationship between the computer and brain is termed as an EEG-based brain-computer interface (BCI). The objective of this survey is to presents an analysis of the existing distinct BCIs based on EEG. Methods This survey provides a detailed review of more than 60 research papers presenting the BCI-based EEG, like motor imagery-based techniques, spatial filtering-based techniques, Steady-State Visual Evoked Potential (SSVEP)-based techniques, machine learning-based techniques, Event-Related Potential (ERP)-based techniques, and online EEG-based techniques. Subsequently, the research gaps and issues of several EEG-based BCI systems are adopted to help the researchers for better future scope. Results An elaborative analyses as well as discussion have been provided by concerning the parameters, like evaluation metrics, year of publication, accuracy, implementation tool, and utilized datasets obtained by various techniques. Conclusions This survey paper exposes research topics on BCI-based EEG, which helps the researchers and scholars, who are interested in this domain.

Objectives This presents a case for fear and stress stimuli and afterward EEG data analysis. Methods The stress factor had been evoked by a computer horror game correlated with virtual reality (VR) and brain-computer interface (BCI) from OpenBCI, applied for the purpose of brain waves changes observation. Results Results obtained during the initial study were promising and provide conclusions for further research in this field carried out on an expanded group of involved participants. Conclusions The study provided very promising and interesting results. Further investigation with larger amount of participants will be carried out.

COVID’19 is an emerging disease and the precise epidemiological profile does not exist in the world. Hence, the COVID’19 outbreak is treated as a Public Health Emergency of the International Concern by the World Health Organization (WHO). Hence, an effective and optimal prediction of COVID’19 mechanism, named Jaya Spider Monkey Optimization-based Deep Convolutional long short-term classifier (JayaSMO-based Deep ConvLSTM) is proposed in this research to predict the rate of confirmed, death, and recovered cases from the time series data. The proposed COVID’19 prediction method uses the COVID’19 data, which is the trending domain of research at the current era of fighting the COVID’19 attacks thereby, to reduce the death toll. However, the proposed JayaSMO algorithm is designed by integrating the Spider Monkey Optimization (SMO) with the Jaya algorithm, respectively. The Deep ConvLSTM classifier facilitates to predict the COVID’19 from the time series data based on the fitness function. Besides, the technical indicators, such as Relative Strength Index (RSI), Rate of Change (ROCR), Exponential Moving Average (EMA), Williams %R, Double Exponential Moving Average (DEMA), and Stochastic %K, are extracted effectively for further processing. Thus, the resulted output of the proposed JayaSMO-based Deep ConvLSTM is employed for COVID’19 prediction. Moreover, the developed model obtained the better performance using the metrics, like Mean Square Error (MSE), and Root Mean Square Error (RMSE) by considering confirmed, death, and the recovered cases of COVID’19 for China and Oman. Thus, the proposed JayaSMO-based Deep ConvLSTM showed improved results with a minimal MSE of 1.791, and the minimal RMSE of 1.338 based on confirmed cases in Oman. In addition, the developed model achieved the death cases with the values of 1.609, and 1.268 for MSE and RMSE, whereas the MSE and the RMSE value of 1.945, and 1.394 is achieved by the developed model using recovered cases in China.

Objectives The appropriate care for patients admitted in Intensive care units (ICUs) is becoming increasingly prominent, thus recognizing the use of machine learning models. The real-time prediction of mortality of patients admitted in ICU has the potential for providing the physician with the interpretable results. With the growing crisis including soaring cost, unsafe care, misdirected care, fragmented care, chronic diseases and evolution of epidemic diseases in the domain of healthcare demands the application of automated and real-time data processing for assuring the improved quality of life. The intensive care units (ICUs) are responsible for generating a wealth of useful data in the form of Electronic Health Record (EHR). This data allows for the development of a prediction tool with perfect knowledge backing. Method We aimed to build the mortality prediction model on 2012 Physionet Challenge mortality prediction database of 4,000 patients admitted in ICU. The challenges in the dataset, such as high dimensionality, imbalanced distribution and missing values, were tackled with analytical methods and tools via feature engineering and new variable construction. The objective of the research is to utilize the relations among the clinical variables and construct new variables which would establish the effectiveness of 1-Dimensional Convolutional Neural Network (1-D CNN) with constructed features. Results Its performance with the traditional machine learning algorithms like XGBoost classifier, Light Gradient Boosting Machine (LGBM) classifier, Support Vector Machine (SVM), Decision Tree (DT), K-Neighbours Classifier (K-NN), and Random Forest Classifier (RF) and recurrent models like Long Short-Term Memory (LSTM) and LSTM-attention is compared for Area Under Curve (AUC). The investigation reveals the best AUC of 0.848 using 1-D CNN model. Conclusion The relationship between the various features were recognized. Also, constructed new features using existing ones. Multiple models were tested and compared on different metrics.

Objectives The most common technique of determining biological paternity or another relationship among people are the investigations of DNA polymorphism called Fingerprinting DNA. The key concept of these investigations is the statistical analysis, which leads to obtain the likelihood ratio (LR), sometimes called the paternity index. Methods Among the different assumptions stated in these computations is a mutation model (this model is used for all the computations). Results and conclusions Although its influence on LR is usually negligible, there are some situations (when the mother–child mutation arises) when it is crucial.