On the mutation model used in the fingerprinting DNA
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Andrzej Krajka
Abstract
Objectives
The most common technique of determining biological paternity or another relationship among people are the investigations of DNA polymorphism called Fingerprinting DNA. The key concept of these investigations is the statistical analysis, which leads to obtain the likelihood ratio (LR), sometimes called the paternity index.
Methods
Among the different assumptions stated in these computations is a mutation model (this model is used for all the computations).
Results and conclusions
Although its influence on LR is usually negligible, there are some situations (when the mother–child mutation arises) when it is crucial.
Research funding: None declared.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication. Authors state no conflict of interest.
Ethical Approval: The conducted research is not related to either human or animal use at Maria Curie-Sklodowska University in Lublin, Poland, even though it concerns DNA data analysis.
Employment or leadership: None declared.
Honorarium: None declared.
References
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/bams-2020-0057).
© 2020 Walter de Gruyter GmbH, Berlin/Boston
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