Deep learning of the role of interleukin IL-17 and its action in promoting cancer
-
Alessandro Nutini
and
Ayesha Sohail
Abstract
In breast cancer patients, metastasis remains a major cause of death. The metastasis formation process is given by an interaction between the cancer cells and the microenvironment that surrounds them. In this article, we develop a mathematical model that analyzes the role of interleukin IL-17 and its action in promoting cancer and in facilitating tissue metastasis in breast cancer, using a dynamic analysis based on a stochastic process that accounts for the local and global action of this molecule. The model uses the Ornstein–Uhlembeck and Markov process in continuous time. It focuses on the oncological expansion and the interaction between the interleukin IL-17 and cell populations This analysis tends to clarify the processes underlying the metastasis expansion mechanism both for a better understanding of the pathological event and for a possible better control of therapeutic strategies.
IL-17 is a proinflammatory interleukin that acts when there is tissue damage or when there is a pathological situation caused by an external pathogen or by a pathological condition such as cancer.
This research is focused on the role of interleukin IL-17 which, especially in the case of breast cancer, turns out to be a dominant “communication pin” since it interconnects with the activity of different cell populations affected by the oncological phenomenon. Stochastic modeling strategies, specially the Ornstein-Uhlenbeck process, with the aid of numerical algorithms are elaborated in this review.
The role of IL-17 is discussed in this manuscript at all the stages of cancer. It is discussed that IL-17 also acts as “metastasis promoter” as a result of its proinflammatory nature. The stochastic nature of IL-17 is discussed based on the evidence provided by recent literature.
The resulting dynamical analysis can help to select the most appropriate therapeutic strategy.
Cancer cells, in the case of breast cancer, have high level of IL-17 receptors (IL-17R); therefore the interleukin itself has direct effects on these cells. Immunotherapy research, focused on this cytokine and interlinked with the stochastic modeling, seems to be a promising avenue.
Research funding: No funding organization played role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Conflict of interest: The authors declare that they have no conflict of interest.
Ethical approval: The conducted research is not related to either human or animal use.
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Articles in the same Issue
- Research Article
- Robust controller for cancer chemotherapy dosage using nonlinear kernel-based error function
- Review
- Deep learning of the role of interleukin IL-17 and its action in promoting cancer
- Research Articles
- An empirical survey of electroencephalography-based brain-computer interfaces
- Analysis of brain waves changes in stressful situations based on horror game with the implementation of virtual reality and brain-computer interface system: a case study
- Jaya Spider Monkey Optimization-driven Deep Convolutional LSTM for the prediction of COVID’19
- Feature engineering combined with 1-D convolutional neural network for improved mortality prediction
- On the mutation model used in the fingerprinting DNA
