Antibacterial Flavanones and Dihydrochalcones from Macaranga trichocarpa
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Muhamad S. Fareza
,
Didin Mujahidin
Abstract
Previously we had isolated two prenylated flavanones and two prenylated dihydrochalcones, macatrichocarpins A-D (1 - 4), from the acetone extract of the leaves of Macaranga trichocarpa. Reexamination of the fractions containing minor components resulted in the isolation of four more flavonoid derivatives, including two new prenylated dihydrochalcones, oxymacatrichocarpin C (5) and isomacatrichocarpin C (6). The structures of these compounds were determined by the analysis of UV, NMR, and mass spectral data. The eight isolated flavonoids were tested on eight pathogenic bacteria and found to be mostly moderate antibacterial agents, with the lowest MIC value of 26.5 μM achieved by the flavanone macatrichocarpin A (1) against Bacillus subtilis.
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Articles in the same Issue
- Three New Di-O-glycosyl-C-glucosyl Flavones from the Leaves of Caesalpinia ferrea Mart.
- Amino Phenolics from the Fruit of the Argan Tree Argania spinosa (Skeels L.)
- Synthesis and Antimicrobial Evaluation of 2-(p-Substituted Phenyl)-5-[(4-substituted piperazin-1-yl)acetamido]-benzoxazoles
- Antibacterial Flavanones and Dihydrochalcones from Macaranga trichocarpa
- Chemical Constituents and Biological Activities of Cirsium leucopsis, C. sipyleum, and C. eriophorum
- Antihyperglycemic Activities of Extracts of the Mistletoes Plicosepalus acaciae and P. curviflorus in Comparison to their Solid Lipid Nanoparticle Suspension Formulations
- Effect of Copper Toxicity on Root Morphology, Ultrastructure, and Copper Accumulation in Moso Bamboo (Phyllostachys pubescens)
- Evaluation of Cucurbita maxima Extract against Scopolamine- Induced Amnesia in Rats: Implication of Tumour Necrosis Factor Alpha
- Effect of Debarking Water from Norway Spruce (Picea abies) on the Growth of Five Species ofWood-Decaying Fungi
