Synthesis and Antimicrobial Evaluation of 2-(p-Substituted Phenyl)-5-[(4-substituted piperazin-1-yl)acetamido]-benzoxazoles
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Mustafa Arisoy
,
Fatma Kaynak-Onurdag
Abstract
series of 2-(p-substituted phenyl)-5-(2-{4-[(p-chloro-fluorophenyl)=phenyl] piperazin-1-yl}- acetamido)-benzoxazoles were synthesized and tested for their antimicrobial activities. The structures of the new derivatives were elucidated by spectral techniques. The minimum inhibitory concentrations (MIC) of the new benzoxazoles, along with those of previously synthesized analogues, were determined against standard bacterial and fungal strains and drug-resistant isolates, and compared with those of several reference drugs. The new benzoxazole derivatives were found to possess a broad spectrum of antimicrobial activity with MIC values of 32 - 1024 μg/ml. Although the standard drugs were more active against the tested pathogens, the activities of the new benzoxazoles and the reference drugs were largely similar against the drug-resistant isolates.
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Articles in the same Issue
- Three New Di-O-glycosyl-C-glucosyl Flavones from the Leaves of Caesalpinia ferrea Mart.
- Amino Phenolics from the Fruit of the Argan Tree Argania spinosa (Skeels L.)
- Synthesis and Antimicrobial Evaluation of 2-(p-Substituted Phenyl)-5-[(4-substituted piperazin-1-yl)acetamido]-benzoxazoles
- Antibacterial Flavanones and Dihydrochalcones from Macaranga trichocarpa
- Chemical Constituents and Biological Activities of Cirsium leucopsis, C. sipyleum, and C. eriophorum
- Antihyperglycemic Activities of Extracts of the Mistletoes Plicosepalus acaciae and P. curviflorus in Comparison to their Solid Lipid Nanoparticle Suspension Formulations
- Effect of Copper Toxicity on Root Morphology, Ultrastructure, and Copper Accumulation in Moso Bamboo (Phyllostachys pubescens)
- Evaluation of Cucurbita maxima Extract against Scopolamine- Induced Amnesia in Rats: Implication of Tumour Necrosis Factor Alpha
- Effect of Debarking Water from Norway Spruce (Picea abies) on the Growth of Five Species ofWood-Decaying Fungi
