Antihyperglycemic Activities of Extracts of the Mistletoes Plicosepalus acaciae and P. curviflorus in Comparison to their Solid Lipid Nanoparticle Suspension Formulations
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Hibah M. Aldawsari
,
Gihan S. Labib
Abstract
The antihyperglycemic activity of the extracts and preparations of solid lipid nanoparticle suspensions of two mistletoes growing in Saudi Arabia, Plicosepalus acaciae and P. curviflorus, as well as their possible antioxidant effect were investigated in a type 2 diabetic animal model. Type 2 diabetes was induced in adult maleWistar rats by a high-fat diet followed by injection of streptozotocin (STZ). The diabetic rats were treated in parallel with pioglitazone hydrochloride (PIO), non-toxic extracts of P. acaciae and P. curviflorus, as well as three different solid lipid nanoparticle (SLN) suspension formulations prepared from each of the two extracts. Blood glucose level, insulin resistance, oxidative stress parameters, and antioxidant markers were determined. The total extracts of P. acaciae and P. curviflorus as well as the SLN formulations exhibited a significant blood glucose-lowering effect associated with antioxidant effects in the diabetic rats. The SLN preparation with the highest lipid content gave the best result. Reduction of hyperglycemia and insulin resistance in the diabetic rats was, at least partly, due to the antioxidant activities of the extracts and their SLN formulations.
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Articles in the same Issue
- Three New Di-O-glycosyl-C-glucosyl Flavones from the Leaves of Caesalpinia ferrea Mart.
- Amino Phenolics from the Fruit of the Argan Tree Argania spinosa (Skeels L.)
- Synthesis and Antimicrobial Evaluation of 2-(p-Substituted Phenyl)-5-[(4-substituted piperazin-1-yl)acetamido]-benzoxazoles
- Antibacterial Flavanones and Dihydrochalcones from Macaranga trichocarpa
- Chemical Constituents and Biological Activities of Cirsium leucopsis, C. sipyleum, and C. eriophorum
- Antihyperglycemic Activities of Extracts of the Mistletoes Plicosepalus acaciae and P. curviflorus in Comparison to their Solid Lipid Nanoparticle Suspension Formulations
- Effect of Copper Toxicity on Root Morphology, Ultrastructure, and Copper Accumulation in Moso Bamboo (Phyllostachys pubescens)
- Evaluation of Cucurbita maxima Extract against Scopolamine- Induced Amnesia in Rats: Implication of Tumour Necrosis Factor Alpha
- Effect of Debarking Water from Norway Spruce (Picea abies) on the Growth of Five Species ofWood-Decaying Fungi
