Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives
-
Mahmoud Farouk
,
Salman Alrokayan
Abstract
3-Substituted quinazoline-2,4(1H,3H)-dione and 2,3-di-substituted quinazolineone derivatives attract considerable interest due to their pharmacological properties. In this paper, we report the synthesis of N-substituted-3-nitrophthalimide derivatives II–III, the reactions of phthalimide III with amines, hydrazines, and amino acid derivatives to synthesise a small library of 3-substituted-5-nitroquinazoline-2,4(1H,3H)-diones IV–XIV and 2,3-di-substituted-6-nitro-quinazolineones XVIII–XIX.
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© 2012 Institute of Chemistry, Slovak Academy of Sciences
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Articles in the same Issue
- Characterisation of VOC composition of Slovak monofloral honeys by GC×GC-TOF-MS
- Combustion-derived CdO nanopowder as a heterogeneous basic catalyst for efficient synthesis of sulfonamides from aromatic amines using p-toluenesulfonyl chloride
- Molybdate sulfonic acid: preparation, characterization, and application as an effective and reusable catalyst for octahydroxanthene-1,8-dione synthesis
- Enantioselective extraction of hydrophilic 2-chloromandelic acid enantiomers by hydroxypropyl-β-cyclodextrin: experiments and modeling
- Attrition of dolomitic lime in a fluidized-bed reactor at high temperatures
- Improvement of aquatic pollutant partition coefficient correlations using 1D molecular descriptors — chlorobenzene case study
- Mercury characterisation in urban particulate matter
- Thermal decomposition of lanthanide(III) complexes of bis-(salicylaldehyde)-1,3-propylenediimine Schiff base ligand
- Effect of hyamine on electrochemical behaviour of brass alloy in HNO3 solution
- Calorimetric determination of the effect of additives on cement hydration process
- Entrapment of ethyl vanillin in calcium alginate and calcium alginate/poly(vinyl alcohol) beads
- Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives
- Virtual screening of imidazole analogs as potential hepatitis C virus NS5B polymerase inhibitors
- A new phenanthroindolizidine alkaloid from Tylophora indica
