Startseite A regio- and stereoselective three-component synthesis of 5-(trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidine derivatives under solvent-free conditions
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A regio- and stereoselective three-component synthesis of 5-(trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidine derivatives under solvent-free conditions

  • Abbas Rahmati EMAIL logo
Veröffentlicht/Copyright: 21. Mai 2011
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Chemical Papers
Aus der Zeitschrift Chemical Papers Band 65 Heft 4

Abstract

An efficient one-pot method for regio- and stereoselective synthesis of 5-(trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidines under solvent-free and catalyst-free conditions has been developed. The method involves employing a three-component condensation reaction of an aromatic aldehyde and ethyl 4,4,4-trifluoro-3-oxobutanoate or 1,1,1-trifluoropentane-2,4-dione in the presence of 1,2,4-triazol-3-amine at 90°C.

Keywords: fluorinated compounds; 1,2,4-triazol-3-amine; solvent-free; catalyst-free

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Published Online: 2011-5-21
Published in Print: 2011-8-1

© 2011 Institute of Chemistry, Slovak Academy of Sciences

Artikel in diesem Heft

  1. Lipid retention of novel pressurized extraction vessels as a function of the number of static and flushing cycles, flush volume, and flow rate
  2. Determination of curcuminoids in substances and dosage forms by cyclodextrin-mediated capillary electrophoresis with diode array detection
  3. Interaction of Moringa oleifera seed lectin with humic acid
  4. Hybrid process scheme for the synthesis of ethyl lactate: conceptual design and analysis
  5. Zinc catalyst recycling in the preparation of (all-rac)-α-tocopherol from trimethylhydroquinone and isophytol
  6. Denitrification of simulated nitrate-rich wastewater using sulfamic acid and zinc scrap
  7. Anaerobic treatment of biodiesel by-products in a pilot scale reactor
  8. Preparation of magnesium hydroxide from nitrate aqueous solution
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  10. Synthesis and crystal and molecular structures of N,N′-methylenedipyridinium tetrachlorozincate(II) and N,N′-methylenedipyridinium tetrachlorocadmate(II)
  11. Effects of denaturing acid on the self-association behaviour of poly(ethylene glycol)-block-poly(γ-benzyl l-glutamate)-graft-poly(ethylene glycol) copolymer in ethanol
  12. Properties of poly(γ-benzyl l-glutamate) membrane modified by polyurethane containing carboxyl group
  13. Theoretical thermo-optical patterns relevant to glass crystallisation
  14. Morphology dependence of 1,2-diphenylethylenediamine-derived organogelator templates in solvents and their influence in the production of nanostructured silica
  15. Ferric hydrogensulphate as a recyclable catalyst for the synthesis of fluorescein derivatives
  16. An alternative synthetic process of p-acetaminobenzenesulfonyl chloride through combined chlorosulfonation by HClSO3 and PCl5
  17. An efficient and novel one-pot synthesis of 2,4,5-triaryl-1H-imidazoles catalyzed by UO2(NO3)2·6H2O under heterogeneous conditions
  18. Stereoselective synthesis of the polar part of mycestericins E and G
  19. A regio- and stereoselective three-component synthesis of 5-(trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidine derivatives under solvent-free conditions
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https://doi.org/10.2478/s11696-011-0034-1
Schlagwörter für diesen Artikel
fluorinated compounds; 1,2,4-triazol-3-amine; solvent-free; catalyst-free

Artikel in diesem Heft

  1. Lipid retention of novel pressurized extraction vessels as a function of the number of static and flushing cycles, flush volume, and flow rate
  2. Determination of curcuminoids in substances and dosage forms by cyclodextrin-mediated capillary electrophoresis with diode array detection
  3. Interaction of Moringa oleifera seed lectin with humic acid
  4. Hybrid process scheme for the synthesis of ethyl lactate: conceptual design and analysis
  5. Zinc catalyst recycling in the preparation of (all-rac)-α-tocopherol from trimethylhydroquinone and isophytol
  6. Denitrification of simulated nitrate-rich wastewater using sulfamic acid and zinc scrap
  7. Anaerobic treatment of biodiesel by-products in a pilot scale reactor
  8. Preparation of magnesium hydroxide from nitrate aqueous solution
  9. Impact of the type of anodic film formed and deposition time on the characteristics of porous anodic aluminium oxide films containing Ni metal
  10. Synthesis and crystal and molecular structures of N,N′-methylenedipyridinium tetrachlorozincate(II) and N,N′-methylenedipyridinium tetrachlorocadmate(II)
  11. Effects of denaturing acid on the self-association behaviour of poly(ethylene glycol)-block-poly(γ-benzyl l-glutamate)-graft-poly(ethylene glycol) copolymer in ethanol
  12. Properties of poly(γ-benzyl l-glutamate) membrane modified by polyurethane containing carboxyl group
  13. Theoretical thermo-optical patterns relevant to glass crystallisation
  14. Morphology dependence of 1,2-diphenylethylenediamine-derived organogelator templates in solvents and their influence in the production of nanostructured silica
  15. Ferric hydrogensulphate as a recyclable catalyst for the synthesis of fluorescein derivatives
  16. An alternative synthetic process of p-acetaminobenzenesulfonyl chloride through combined chlorosulfonation by HClSO3 and PCl5
  17. An efficient and novel one-pot synthesis of 2,4,5-triaryl-1H-imidazoles catalyzed by UO2(NO3)2·6H2O under heterogeneous conditions
  18. Stereoselective synthesis of the polar part of mycestericins E and G
  19. A regio- and stereoselective three-component synthesis of 5-(trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidine derivatives under solvent-free conditions
  20. Precautions in using global kinetic and thermodynamic models for characterization of drug release from multivalent supports
  21. A sandwich anion receptor by a BODIPY dye bearing two calix[4]pyrrole units
  22. What causes iron-sulphur bonds in active sites of one-iron superoxide reductase and two-iron superoxide reductase to differ?
  23. MTD-PLS and docking study for a series of substituted 2-phenylindole derivatives with oestrogenic activity
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