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Morphological patterns of poly(N-isopropylacrylamide) derivatives synthesized with EGDMA, DEGDMA, and TEGDMA crosslinkers for application as thermosensitive drug carriers

  • Witold Musial EMAIL logo , Vanja Kokol , Tivadar Fecko and Bojana Voncina
Published/Copyright: September 23, 2010
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Chemical Papers
From the journal Chemical Papers Volume 64 Issue 6

Abstract

A number of poly(N-isopropylacrylamide) (polyNIPAM) microgels were prepared with dimethacrylate cross-linking agents of various lengths, ether and ester groups in the backbone, and pendant vinylidine functionality. These materials were characterized by examining their morphological patterns using optical and scanning electron microscopy. When ethylene glycol dimethacrylate (EGDMA) was used as a cross-linking agent, microspheres of approximately 1 μm in diameter were obtained. Diethylene glycol dimethacrylate (DEGDMA) cross-linking resulted in relatively large spherical structures (1–5 μm) as well as spherical nanostructures (200 nm). Using triethylene glycol dimethacrylate (TEGDMA) resulted in spheres with diameters between 1 μm and 3 μm. The hydrodynamic particle diameter decreased with the increasing chain length of the dimethacrylate cross-linking agents. The turbidity increased with the temperature of transition points occurring at approximately 31–32°C confirming the thermosensitivity of the obtained polymeric structures.

Keywords: poly(N-isopropylacrylamide); skin surface temperature; dimethacrylate cross-linking agent; thermosensitivity; scanning electron microscopy; optical microscopy

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Published Online: 2010-9-23
Published in Print: 2010-12-1

© 2010 Institute of Chemistry, Slovak Academy of Sciences

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  5. Determination of catechin and epicatechin in the peel of apple varieties resistant and non-resistant to apple scab
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  14. Influence of a Fe/activated carbon catalyst and reaction parameters on methane decomposition during the synthesis of carbon nanotubes
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https://doi.org/10.2478/s11696-010-0065-z
Keywords for this article
poly(N-isopropylacrylamide); skin surface temperature; dimethacrylate cross-linking agent; thermosensitivity; scanning electron microscopy; optical microscopy

Articles in the same Issue

  1. Chemical conjugation of biomacromolecules: A mini-review
  2. Talaromyces flavus and its metabolites
  3. Application of non-steroidal anti-inflammatory drugs for palladium determination
  4. A naked-eye, selective and sensitive chemosensor for fluoride ion
  5. Determination of catechin and epicatechin in the peel of apple varieties resistant and non-resistant to apple scab
  6. The use of sulfated tin oxide as solid superacid catalyst for heterogeneous transesterification of Jatropha curcas oil
  7. Effect of pH and washing on calcium and magnesium distribution between pulp and filtrate
  8. Influence of lead dioxide electrodes morphology on kinetics and current efficiency of oxygen-ozone evolution reactions
  9. Synthesis of methyl acetoacetate from acetone and dimethyl carbonate with alkali-promoted MgO catalysts
  10. Synthesis, crystal structure, and 1H NMR spectra of a chloride-bridged chain complex of dinuclear ruthenium(II,III) 3,4,5-tri(ethoxy-d 5)benzoate
  11. Modification of poly(vinyl alcohol) membrane via blending with poly(γ-benzyl l-glutamate)-block-poly(ethylene glycol) copolymer
  12. Oxidative polymerization of anilinium 5-sulfosalicylate with peroxydisulfate in water
  13. Morphological patterns of poly(N-isopropylacrylamide) derivatives synthesized with EGDMA, DEGDMA, and TEGDMA crosslinkers for application as thermosensitive drug carriers
  14. Influence of a Fe/activated carbon catalyst and reaction parameters on methane decomposition during the synthesis of carbon nanotubes
  15. Microwave assisted one pot synthesis of 7-substituted 2-(2-oxo-2H-chromen-3-yl)acetic acids as precursors of new anti-tumour compounds
  16. ZnO nanoparticles in the synthesis of AB ring core of camptothecin
  17. Novel benzopyranopyridine derivatives of 2-amino-3-formylchromone
  18. Polyethylene glycol-mediated synthesis of decahydroacridine-1,8-diones catalyzed by ceric ammonium nitrate
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