Startseite Modelling of enzymatic reaction in an internal loop airlift reactor
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Modelling of enzymatic reaction in an internal loop airlift reactor

  • I. Sikula EMAIL logo , M. Juraščík und J. Markoš
Veröffentlicht/Copyright: 1. Dezember 2006
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Abstract

Gas-liquid reaction carried out in an internal loop airlift reactor was modelled and subjected to the scale-up procedure. Homogeneous oxidation of glucose to gluconic acid catalyzed by Gluzyme 10000 BG, a commercial product containing the enzymes glucose oxidase and catalase as active components, was chosen as the model system. The kinetic parameters were obtained using a 12-L airlift reactor considered as a CSTR. The behaviour of a large-scale internal loop airlift reactor was modelled dividing the reactor sections into a series of tank reactors. The reliability of the model was verified by comparing experimental measurements with the simulation results obtained employing 40-L and 200-L airlift reactors. The designed model could be suitable to predict the behaviour of large-scale internal loop airlift reactors.

[1] Russell, A. B., Thomas, C. R., and Lilly, M. D., Bioprocess Biosyst. Eng. 12, 71 (1995). Suche in Google Scholar

[2] Chisti, Y., Appl. Mech. Rev. 51, 101 (1998). http://dx.doi.org/10.1115/1.309898910.1115/1.3098989Suche in Google Scholar

[3] Luttmann, R., Thoma, M., Buchholz, H., and Schugerl, K., Comput. Chem. Eng. 7, 43 (1983). http://dx.doi.org/10.1016/0098-1354(83)85006-610.1016/0098-1354(83)85006-6Suche in Google Scholar

[4] Adler, I., Deckwer, W. D., and Schugerl, K., Chem. Eng. Sci. 37, 417 (1982). http://dx.doi.org/10.1016/0009-2509(82)80094-810.1016/0009-2509(82)80094-8Suche in Google Scholar

[5] Turner, J. R. and Mills, P. L., Chem. Eng. Sci. 45, 2317 (1990). http://dx.doi.org/10.1016/0009-2509(90)80111-Q10.1016/0009-2509(90)80111-QSuche in Google Scholar

[6] Kanai, T., Uzumaki, T., and Kawase, Y., Comput. Chem. Eng. 20, 1089 (1996). http://dx.doi.org/10.1016/0098-1354(95)00225-110.1016/0098-1354(95)00225-1Suche in Google Scholar

[7] Schumpe, A., Chem. Eng. Sci. 48, 153 (1993). http://dx.doi.org/10.1016/0009-2509(93)80291-W10.1016/0009-2509(93)80291-WSuche in Google Scholar

[8] Rischbieter, E., Schumpe, A., and Wunder, V., J. Chem. Eng. Data 41, 809 (1996). http://dx.doi.org/10.1021/je960039c10.1021/je960039cSuche in Google Scholar

[9] Nakamura, T. and Yasuyuki, O., J. Biochem. (Tokyo) 52, 214 (1962). 10.1093/oxfordjournals.jbchem.a127599Suche in Google Scholar PubMed

[10] Gibson, H., Bennett, E., Swoboda, P., and Massey, V., J. Biol. Chem. 239, 3927 (1964). Suche in Google Scholar

[11] Beltrame, P., Comotti, M., Pina, C. D., and Rossi, M., J. Catal. 228, 282 (2004). http://dx.doi.org/10.1016/j.jcat.2004.09.01010.1016/j.jcat.2004.09.010Suche in Google Scholar

[12] Duke, F. R., Weibel, M., Phage, D. S., Bulgrin, V. G., and Luthy, J., J. Am. Chem. Soc. 91, 3904 (1969). http://dx.doi.org/10.1021/ja01042a03810.1021/ja01042a038Suche in Google Scholar

[13] Juraščík, M., Sikula, I., Krištofíková, L.’, Rosenberg, M., Annus, J., and Markoš, J., in Proceedings of the 32nd Conference of the Slovak Society of Chemical Engineering. Tatranské Matliare, Slovakia, 2005. Suche in Google Scholar

[14] Juraščík, M., Hucík, M., Sikula, I., Annus, J., and Markoš, J., Chem. Pap. 60, 441 (2006). http://dx.doi.org/10.2478/s11696-006-0080-210.2478/s11696-006-0080-2Suche in Google Scholar

[15] Blažej, M., Kiša, M., and Markoš, J., Chem. Eng. Process. 43, 1519 (2004). http://dx.doi.org/10.1016/j.cep.2004.02.00310.1016/j.cep.2004.02.003Suche in Google Scholar

[16] Heijnen, J. J., Hols, J., Van der Lans, R. J. G. M., Van Leeuwen, H. L. J. M., Mulder, A., and Weltevrede, R., Chem. Eng. Sci. 52, 2527 (1997). http://dx.doi.org/10.1016/S0009-2509(97)00070-510.1016/S0009-2509(97)00070-5Suche in Google Scholar

[17] Juraščík, M., Blažej, M., Annus, J., and Markoš, J., Chem. Eng. J., accepted for publication (2006). Suche in Google Scholar

[18] Klein, J., Rosenberg, M., Markoš, J., Dolgoš, O., Krošlák, M., and Krištofíková, L.’, Biochem. Eng. J. 10, 197 (2002). http://dx.doi.org/10.1016/S1369-703X(01)00181-410.1016/S1369-703X(01)00181-4Suche in Google Scholar

[19] Juraščík, M., Sikula, I., Rosenberg, M., and Markoš, J., Chem. Biochem. Eng. Q., submitted for publication (2005). Suche in Google Scholar

[20] Blažej, M., Juraščík, M., Annus, J., and Markoš, J., J. Chem. Technol. Biotechnol. 29, 1405 (2004). http://dx.doi.org/10.1002/jctb.114410.1002/jctb.1144Suche in Google Scholar

[21] André, G., Robinson, C. W., and Moo-Young, M., Chem. Eng. Sci. 38, 1845 (1983). http://dx.doi.org/10.1016/0009-2509(83)85040-410.1016/0009-2509(83)85040-4Suche in Google Scholar

[22] Levenspiel, O., Chemical Reaction Engineering. Wiley, New York, 1962. Suche in Google Scholar

[23] Deckwer, W. D., Burckhart, R., and Zoll, G., Chem. Eng. Sci. 29, 2177 (1974). http://dx.doi.org/10.1016/0009-2509(74)80025-410.1016/0009-2509(74)80025-4Suche in Google Scholar

[24] Deckwer, W. D. and Schumpe, A., Chem. Eng Sci. 48, 889 (1993). http://dx.doi.org/10.1016/0009-2509(93)80328-N10.1016/0009-2509(93)80328-NSuche in Google Scholar

[25] Towell, G. D. and Ackerman, G. H., in Proceedings of the 2nd International Symposium on Chemical Reactor Engineering. Amsterdam, The Netherlands, 1972. Suche in Google Scholar

[26] Rubio, F. C., Garcia, J. L., Molina, E., and Chisti, Y., Chem. Eng. J. 84, 43 (2001). http://dx.doi.org/10.1016/S1385-8947(00)00261-810.1016/S1385-8947(00)00261-8Suche in Google Scholar

[27] Rubio, F. C., Fernandez, F. G. A., Perez, J. A. S., Camacho, F. G., and Grima, E. M., Biotechnol. Bioeng. 62, 71 (1999). http://dx.doi.org/10.1002/(SICI)1097-0290(19990105)62:1<71::AID-BIT9>3.0.CO;2-T10.1002/(SICI)1097-0290(19990105)62:1<71::AID-BIT9>3.0.CO;2-TSuche in Google Scholar

[28] Reith, T., Renken, S., and Israel, B. A., Chem. Eng. Sci. 23, 619 (1968). http://dx.doi.org/10.1016/0009-2509(68)89007-410.1016/0009-2509(68)89007-4Suche in Google Scholar

[29] Juraščík, M., Sikula, I., Annus, J., and Markoš, J., in Proceedings of the 32nd Conference of the Slovak Society of Chemical Engineering. Tatranské Matliare, Slovakia, 2005. Suche in Google Scholar

Published Online: 2006-12-1
Published in Print: 2006-12-1

© 2006 Institute of Chemistry, Slovak Academy of Sciences

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