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Determination of risperidone at picogram level in human urine by luminol—H2O2 chemiluminescence

  • X. Xie EMAIL logo , X. Shao and Z. Song
Published/Copyright: August 1, 2006
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Chemical Papers
From the journal Chemical Papers Volume 60 Issue 4

Abstract

A simple flow-injection chemiluminescence method with synergistic enhancement has been investigated for the rapid and sensitive determination of antipsychotic risperidone. The synergistic action was significant in the chemiluminescence system of luminol—hydrogen peroxide with risperidone as an enhancer. The increased chemiluminescence intensity was correlated with risperidone concentration within the range from 10 pg mL−1 to 1.0 ng mL−1 with relative standard deviations lower than 5.0 % and the detection limit of 4 pg mL−1. At a flow rate of 2.0 mL min−1, the flow-injection chemiluminescence method exhibited both a high sensitivity and excellent selectivity giving a throughput of 120 times per hour. The proposed method was successfully applied to determine the risperidone content in human urine without any pretreatment. It was found that the excretive amounts of risperidone reached their maximum after taking 2.0 mg of risperidone for 1 h, with a total excretive ratio of 17.37 % in 8.5 h.

Keywords: chemiluminescence; human urine; risperidone; flow-injection analysis

[1] Grant, S. and Fitton, A., Drugs 48, 253 (1994). 10.2165/00003495-199448020-00009Search in Google Scholar

[2] Marder, R. and Meibach, R., Am. J. Psychiatry 151, 825 (1994). 10.1176/ajp.151.6.825Search in Google Scholar

[3] Katz, I. R., Jeste, D. V., Mintzer, J. E., Clyde, C., Napolitano, J., and Brecher, M., J. Clin. Psychiatry 60, 107 (1999). 10.4088/JCP.v60n0207Search in Google Scholar

[4] Llerena, A., Berecz, R., Dorado, P., de la Garza, C. S., Norberto, M. J., Caceres, M., and Gutierrez, J. R., J. Chromatogr., B 783, 213 (2003). http://dx.doi.org/10.1016/S1570-0232(02)00661-X10.1016/S1570-0232(02)00661-XSearch in Google Scholar

[5] Titier, K., Déridet, E., Cardone, E., Abouelfath, A., and Moore, N., J. Chromatogr., B 772, 373 (2002). http://dx.doi.org/10.1016/S1570-0232(02)00091-010.1016/S1570-0232(02)00091-0Search in Google Scholar

[6] Remmerie, B. M. M., Sips, L. L. A., de Vries, R., de Jong, J., Schothuis, A. M., Hooijschuur, E. W. J., and van de Merbel, N. C., J. Chromatogr., B 783, 461 (2003). http://dx.doi.org/10.1016/S1570-0232(02)00715-810.1016/S1570-0232(02)00715-8Search in Google Scholar

[7] Shen, Y. L., Wu, H. L., Ko, W. K., and Wu, S. M., Anal. Chim. Acta 460, 201 (2002). http://dx.doi.org/10.1016/S0003-2670(02)00239-810.1016/S0003-2670(02)00239-8Search in Google Scholar

[8] Pucci, V., Raggi, M. A., and Kennderler, E., J. Liq. Chromatogr. Relat. Technol. 23, 25 (2000). http://dx.doi.org/10.1081/JLC-10010143310.1081/JLC-100101433Search in Google Scholar

[9] Powe, A. M., Fletcher, K. A., St. Luce, N. N., Lowry, M., Neal, S., McCarroll, M. E., Oldham, P. B., McGown, L. B., and Warner, I. M., Anal. Chem. 76, 4614 (2004). http://dx.doi.org/10.1021/ac040095d10.1021/ac040095dSearch in Google Scholar

[10] Kricka, L. J., Anal. Chim. Acta 500, 279 (2003). http://dx.doi.org/10.1016/S0003-2670(03)00809-210.1016/S0003-2670(03)00809-2Search in Google Scholar

[11] Song, Z. H. and Zhang, N., Chin. J. Chem. 21, 175 (2003). Search in Google Scholar

[12] Song, Z. H. and Wang, C. N., J. Pharm. Biomed. Anal. 36, 491 (2004). http://dx.doi.org/10.1016/j.jpba.2004.06.00510.1016/j.jpba.2004.06.005Search in Google Scholar PubMed

[13] Pharmacopoeia of the People’s Republic of China, Part 2. Chemical Industry Press, Beijing, 2000. Search in Google Scholar

[14] Mannens, G., Huang, M. L., Meuldermans, W., Hendrickx, J., Woestenborghs, R., and Heykants, J., Drug Metab. Dispos. 21, 1134 (1993). Search in Google Scholar

[15] Huang, S. K., Comprehensive Textbook of Pharmacokinetics, p. 13. China Pharmaceutical University Press, Nanjing, China, 1989. Search in Google Scholar

Published Online: 2006-8-1
Published in Print: 2006-8-1

© 2006 Institute of Chemistry, Slovak Academy of Sciences

Articles in the same Issue

  1. Influence of medium on the kinetics of oxidation of iron(II) ion with t-butyl hydroperoxide
  2. Synthesis of new thiazolo[2,3-b]pyrimidine derivatives of pharmaceutical interest
  3. Enthalpic analysis of the CaTiSiO5 system
  4. Kinetic, spectrophotometric determination of nanogram levels of manganese(II) using catalytic azo dye—potassium periodate—1,10-phenanthroline system
  5. Application of a ternary complex of tungsten(VI) with 4-nitrocatechol and thiazolyl blue for extraction-spectrophotometric determination of tungsten
  6. Determination of risperidone at picogram level in human urine by luminol—H2O2 chemiluminescence
  7. Electrochemical dissolution of chalcopyrite studied by voltammetry of immobilized microparticles
  8. Colon tissue concentrations of copper, iron, selenium, and zinc in colorectal carcinoma patients
  9. Structure of tetrakis(pyridinioacetate) neodymium(III) tetrahydrate perchlorate
  10. Thermally stable oligomer—Metal complexes based on oligo-ortho-aminophenol and oligophenylazomethinephenol
  11. Adsorption of SO2 on alumina
  12. One-pot, three-component synthesis of secondary amines and trisubstituted hydrazines from ketones
  13. Synthesis of α,α′-bis(R-benzylidene)cycloalkanones catalyzed by potassium hydrogen sulfate under solvent-free conditions
  14. Electrical conductivity of the molten KF—K2TaF7 system
  15. New substituted mono-and bis(imidazolyl)pyridines and their application in nitroaldolisation reaction
https://doi.org/10.2478/s11696-006-0050-8
Keywords for this article
chemiluminescence; human urine; risperidone; flow-injection analysis

Articles in the same Issue

  1. Influence of medium on the kinetics of oxidation of iron(II) ion with t-butyl hydroperoxide
  2. Synthesis of new thiazolo[2,3-b]pyrimidine derivatives of pharmaceutical interest
  3. Enthalpic analysis of the CaTiSiO5 system
  4. Kinetic, spectrophotometric determination of nanogram levels of manganese(II) using catalytic azo dye—potassium periodate—1,10-phenanthroline system
  5. Application of a ternary complex of tungsten(VI) with 4-nitrocatechol and thiazolyl blue for extraction-spectrophotometric determination of tungsten
  6. Determination of risperidone at picogram level in human urine by luminol—H2O2 chemiluminescence
  7. Electrochemical dissolution of chalcopyrite studied by voltammetry of immobilized microparticles
  8. Colon tissue concentrations of copper, iron, selenium, and zinc in colorectal carcinoma patients
  9. Structure of tetrakis(pyridinioacetate) neodymium(III) tetrahydrate perchlorate
  10. Thermally stable oligomer—Metal complexes based on oligo-ortho-aminophenol and oligophenylazomethinephenol
  11. Adsorption of SO2 on alumina
  12. One-pot, three-component synthesis of secondary amines and trisubstituted hydrazines from ketones
  13. Synthesis of α,α′-bis(R-benzylidene)cycloalkanones catalyzed by potassium hydrogen sulfate under solvent-free conditions
  14. Electrical conductivity of the molten KF—K2TaF7 system
  15. New substituted mono-and bis(imidazolyl)pyridines and their application in nitroaldolisation reaction
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