Synthesis of new thiazolo[2,3-b]pyrimidine derivatives of pharmaceutical interest
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H. Abdel-Razik
Abstract
2H-5-Amino-6-cyano-3,7-dioxothiazolo[2,3-b]pyrimidine was subjected to ring formation affording thiazolo[2,3-b]pyrimidine derivatives. 2H-5-Amino-6-cyano-3,7-dioxo-2-phenylmethylenethiazolo[2,3-b]pyrimidine was also subjected to ring formation affording pyrimido[4,5-d]-, pyrano[2,3-d]-, and pyrido[2,3-d]thiazolo[2,3-b]pyrimidine derivatives. 2-Anilinothiocarbonyl-3,9-dioxo-8-imino-7-phenyl-6-thioxothiazolo[2,3-b]pyrimido[4,5-d]pyrimidine and 8-amino-3,9-dioxo-6-thioxothiazolo[2,3-b]pyrimido[4,5-d]pyrimidine reacted with α-haloactive-methylene compounds to afford heterocyclic compounds containing two, fused and isolated, thiazole moieties, respectively.
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© 2006 Institute of Chemistry, Slovak Academy of Sciences
Articles in the same Issue
- Influence of medium on the kinetics of oxidation of iron(II) ion with t-butyl hydroperoxide
- Synthesis of new thiazolo[2,3-b]pyrimidine derivatives of pharmaceutical interest
- Enthalpic analysis of the CaTiSiO5 system
- Kinetic, spectrophotometric determination of nanogram levels of manganese(II) using catalytic azo dye—potassium periodate—1,10-phenanthroline system
- Application of a ternary complex of tungsten(VI) with 4-nitrocatechol and thiazolyl blue for extraction-spectrophotometric determination of tungsten
- Determination of risperidone at picogram level in human urine by luminol—H2O2 chemiluminescence
- Electrochemical dissolution of chalcopyrite studied by voltammetry of immobilized microparticles
- Colon tissue concentrations of copper, iron, selenium, and zinc in colorectal carcinoma patients
- Structure of tetrakis(pyridinioacetate) neodymium(III) tetrahydrate perchlorate
- Thermally stable oligomer—Metal complexes based on oligo-ortho-aminophenol and oligophenylazomethinephenol
- Adsorption of SO2 on alumina
- One-pot, three-component synthesis of secondary amines and trisubstituted hydrazines from ketones
- Synthesis of α,α′-bis(R-benzylidene)cycloalkanones catalyzed by potassium hydrogen sulfate under solvent-free conditions
- Electrical conductivity of the molten KF—K2TaF7 system
- New substituted mono-and bis(imidazolyl)pyridines and their application in nitroaldolisation reaction
Articles in the same Issue
- Influence of medium on the kinetics of oxidation of iron(II) ion with t-butyl hydroperoxide
- Synthesis of new thiazolo[2,3-b]pyrimidine derivatives of pharmaceutical interest
- Enthalpic analysis of the CaTiSiO5 system
- Kinetic, spectrophotometric determination of nanogram levels of manganese(II) using catalytic azo dye—potassium periodate—1,10-phenanthroline system
- Application of a ternary complex of tungsten(VI) with 4-nitrocatechol and thiazolyl blue for extraction-spectrophotometric determination of tungsten
- Determination of risperidone at picogram level in human urine by luminol—H2O2 chemiluminescence
- Electrochemical dissolution of chalcopyrite studied by voltammetry of immobilized microparticles
- Colon tissue concentrations of copper, iron, selenium, and zinc in colorectal carcinoma patients
- Structure of tetrakis(pyridinioacetate) neodymium(III) tetrahydrate perchlorate
- Thermally stable oligomer—Metal complexes based on oligo-ortho-aminophenol and oligophenylazomethinephenol
- Adsorption of SO2 on alumina
- One-pot, three-component synthesis of secondary amines and trisubstituted hydrazines from ketones
- Synthesis of α,α′-bis(R-benzylidene)cycloalkanones catalyzed by potassium hydrogen sulfate under solvent-free conditions
- Electrical conductivity of the molten KF—K2TaF7 system
- New substituted mono-and bis(imidazolyl)pyridines and their application in nitroaldolisation reaction
