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Fenugreek Supplementation Imparts Erythrocyte Resistance to Cypermethrin Induced Oxidative Changes In Vivo
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Sushma Navayath
Veröffentlicht/Copyright:
10. Februar 2011
Erythrocytes are excellent model to study the xenobiotic induced oxidative changes. Pyrethroid pesticides are increasingly being used in insecticidal preparations from the simple mosquito coils to house hold aerosols to sophisticated ultra low volume foggers and sprays. Cypermethrin a Type II pyrethroid pesticide is used widely in pest control. Fenugreek is a potent antioxidant. We have evaluated the potential of aqueous extract of germinated fenugreek seeds in counteracting cypermethrin induced oxidative changes in erythrocytes of male Wistar rats. Male Wistar rats were treated with 1/10 LD50 (25mg/kg body weight) of cypermethrin and 10 percent aqueous extract of germinated fenugreek for 60 days. Cypermethrin treatment caused significant decrease in non enzymatic antioxidants, glutathione (GSH), vitamin E, vitamin C, increased methemoglobin formation in erythrocytes and increased their mechanical fragility. Treatment with fenugreek reversed the cypermethrin induced oxidative changes in erythrocytes and restored all the parameters to near normal levels. The overall results reveal the ameliorating effect of aqueous extract of germinated fenugreek on cypermethrin induced toxicity in erythrocytes.
Published Online: 2011-2-10
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Artikel in diesem Heft
- Research Article
- Syzygium cumini Seed Extract Protects the Liver Against Lipid Peroxidation with Concurrent Amelioration of Hepatic Enzymes and Lipid Profile of Alcoholic Rats
- Antihypertensive and Vasorelaxant Effects of Cinnamomum zeylanicum Stem Bark Aqueous Extract in Rats
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Schlagwörter für diesen Artikel
antioxidants;
cypermethrin;
fenugreek;
methemoglobin;
osmotic fragility;
ROS
Artikel in diesem Heft
- Research Article
- Syzygium cumini Seed Extract Protects the Liver Against Lipid Peroxidation with Concurrent Amelioration of Hepatic Enzymes and Lipid Profile of Alcoholic Rats
- Antihypertensive and Vasorelaxant Effects of Cinnamomum zeylanicum Stem Bark Aqueous Extract in Rats
- Glucose Uptake-Enhancing Activity of the Ethyl Acetate Extract of Dennettia tripetala in 3T3-L1 Adipocytes
- Fenugreek Supplementation Imparts Erythrocyte Resistance to Cypermethrin Induced Oxidative Changes In Vivo
- Evaluation of Hypoglycemic Activity and Toxicity Profiles of the Leaves of Ficus deltoidea in Rodents
- Influence of Benefits, Barriers and Cues to Action for Complementary and Alternative Medicine Use among University Students
- In vitro (?-Glucosidase and ?-Amylase Inhibition) and in vivo Antidiabetic Property of Phytic Acid (IP6) in Streptozotocin-Nicotinamide-Induced Type 2 Diabetes Mellitus (NIDDM) in Rats
- Effects of Improved Self-Appraisal and Mood Factors on Weight Loss in Obese Women Initiating Supported Exercise
- Chemical Characterization and Evaluation of the Hypoglycemic Effect of Fructooligosaccharides from Psacalium decompositum
- Antibacterial and Antioxidant Activities of Synedrella nodiflora (L.) Gaertn. (Asteraceae)
- Oxygen Bar Effectiveness: A Randomized Quantitative Study
- The Role of Complementary Indigenous Malay Therapies: Perspectives from Palliative Care Patients
- Anti-Inflammatory, Antipyretic and Antioxidant Effect of Some Medicinal Plant Extracts
- Antihyperglycaemic And Renoprotective Effect of Boerhaavia diffusa L. in Experimental Diabetic Rats
- CAM in Canadian Hospitals: The New Frontier?
- Herbal Tonic Does Not Inhibit Estrogen Receptor Negative Mammary Tumor Development in a Transgenic Mouse Model
- Antioxidant and Free Radical Scavenging Activities of Some Fruits
- Pycnogenol (PYC) Induces Apoptosis in Human Fibrosarcoma (HFS) Cells Under Metal-mediated Oxidative Stress
- Evaluation of Anti-inflammatory and Antioxidant Activity of Premna integrifolia Root
- Impact of Mind Body Therapies on Vascular Endothelial Dysfunction and Implications for Cardiovacular Disease Management
- Studies on the Antiulcer and Gastrointestinal Effects of Stem Bark Extract of Bridelia ferruginea
- Study of Antiobesity Effects of Ethanolic and Water Extracts of Grapes Seeds
- Effect of Wrightia tinctoria and Parthenocissus quinquefolia on blood glucose and Insulin levels in the Zucker Diabetic Rat Model
- Short Communication on Medicinal Herbs
- Potent Hypoglycemic Effect of Nigerian Anti-Diabetic Medicinal Plants
- Hepatoprotective Effects and Antioxidant Role of Scutia myrtina on Paracetamol Induced Hepatotoxicity in Rats
- Extract of North American Ginseng (Panax Quinquefolius), Administered to Leukemic, Juvenile Mice Extends their Life Span
- Hepatoprotective Activity of Cyperus tegetum Rhizome Against Paracetamol-Induced Liver Damage in Rats
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