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99mTc gel generators based on zirconium molybdate-99Mo: III: Influence of preparatory conditions of zirconium molybdate-99Mo gel on generator performance
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P. Saraswathy
Veröffentlicht/Copyright:
25. September 2009
Abstract
The effect of subtle variations on zirconium molybdate-99Mo gel preparatory conditions, such as stoichiometry of reactants, pH of gel formation, conditioning of gel granules etc. , prior to elution were investigated primarily to arrive at the conditions resulting in high 99mTc release and minimal 99Mo breakthrough upon elution with normal saline. Zirconium molybdate- 99Mo gels were prepared by reacting solutions of Zr and Mo in mole ratios of 0.75-1.5. Both water and normal saline were used for gel disintegration, and the release of 99mTc and 99Mo from gel columns into eluates was compared. Sharper elution profile of 99mTc, but with significantly higher 99Mo breakthrough (5-8 times), was obtained when water alone was used for disintegration and elution, in comparison to when saline was used.
Gels exhibiting optimum characteristics were found to be formed at a pH of 4-5 by reacting [Zr]:[Mo] in the mole ratio of 1.25:1 and after drying, the product was dispersed into granules by disintegration with normal saline. 99mTc elution efficiency was found to be ∼75% and 99Mo breakthrough ∼0.05%. The elution profile was sharp when a 6 g gel column coupled to a 2 g acidic alumina column (to trap 99Mo) was eluted with 6-9 ml normal saline. Generators containing upto 23 GBq 99Mo were prepared, eluted extensively without changing the alumina column and found to provide pertechnetate of good quality, commensurate with hospital radiopharmacy requirements.
Published Online: 2009-9-25
Published in Print: 2004-4-1
© 2004 Oldenbourg Wissenschaftsverlag GmbH
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Artikel in diesem Heft
- Gerhard L. Stöcklin Memorial Issue. Dedication and Appreciation
- In Memoriam Gerhard L. Stöcklin
- From hot atom chemistry to epithermal chemistry
- Excitation functions of deuteron induced nuclear reactions on enriched 78Kr with particular relevance to the production of 76Br
- Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
- Cross section measurements of proton and deuteron induced formation of 103Ag in natural palladium
- The Auger-electron emitter 165Er: excitation function of the 165Ho(p,n)165Er process
- Cross sections for production of the therapeutic radioisotopes 198Au and 199Au in proton and deuteron induced reactions on 198Pt
- Production of 16N for instrument calibration
- New determination of the half-life of 205Bi
- Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility
- A no-carrier-added 72Se/72As radionuclide generator based on distillation
- The isolation of 99Mo from fission material for use in the 99Mo/99mTc generator for medical use
- 99mTc gel generators based on zirconium molybdate-99Mo: III: Influence of preparatory conditions of zirconium molybdate-99Mo gel on generator performance
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- Neutral oxorhenium(V) and oxotechnetium(V) complexes with novel amide thioether dithiolate ligands derived from cysteine
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- Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T
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