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Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility

  • M. Faßbender , F. M. Nortier , D. R. Phillips , V. T. Hamilton , R. C. Heaton , D. J. Jamriska , J. J. Kitten , L. R. Pitt , L. L. Salazar , F. O. Valdez and E. J. Peterson
Published/Copyright: September 25, 2009
Radiochimica Acta
From the journal Radiochimica Acta Volume 92 Issue 4-6

Abstract

Generator nuclides constitute a convenient tool for applications in nuclear medicine. In this paper, some radiochemical aspects of generator nuclide parents regularly processed at Los Alamos are introduced. The bulk production of the parent nuclides 68Ge, 82Sr, 109Cd and 88Zr using charged particle beams is discussed. Production nuclear reactions for these radioisotopes, and chemical separation procedures are presented. Experimental processing yields correspond to 80%-98% of the theoretical thick target yield. Reaction cross sections are modeled using the code ALICE-IPPE; it is observed that the model largely disagrees with experimental values for the nuclear processes treated. Radionuclide production batches are prepared 1-6 times yearly for sales. Batch activities range from 40 MBq to 75 GBq.

Published Online: 2009-9-25
Published in Print: 2004-4-1

© 2004 Oldenbourg Wissenschaftsverlag GmbH

Articles in the same Issue

  1. Gerhard L. Stöcklin Memorial Issue. Dedication and Appreciation
  2. In Memoriam Gerhard L. Stöcklin
  3. From hot atom chemistry to epithermal chemistry
  4. Excitation functions of deuteron induced nuclear reactions on enriched 78Kr with particular relevance to the production of 76Br
  5. Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
  6. Cross section measurements of proton and deuteron induced formation of 103Ag in natural palladium
  7. The Auger-electron emitter 165Er: excitation function of the 165Ho(p,n)165Er process
  8. Cross sections for production of the therapeutic radioisotopes 198Au and 199Au in proton and deuteron induced reactions on 198Pt
  9. Production of 16N for instrument calibration
  10. New determination of the half-life of 205Bi
  11. Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility
  12. A no-carrier-added 72Se/72As radionuclide generator based on distillation
  13. The isolation of 99Mo from fission material for use in the 99Mo/99mTc generator for medical use
  14. 99mTc gel generators based on zirconium molybdate-99Mo: III: Influence of preparatory conditions of zirconium molybdate-99Mo gel on generator performance
  15. Structure of [N,N´-bis(3,5-di-t-butyl-salicylidene)-2-benzyl-1,3-propanediaminato]nitridotechnetium(V) complex, TcN(bzdbsalpn), and nitrido-bridged linear polymeric chains in crystalline syn-isomer
  16. Neutral oxorhenium(V) and oxotechnetium(V) complexes with novel amide thioether dithiolate ligands derived from cysteine
  17. 188Re(V)-DMSA: in-vitro and in-vivo studies on the individual stereo isomers
  18. Analysis of 188Re-EDTMP complexes by HPLC and ultrafiltration
  19. Semi-remote production of Br-76 and preparation of high specific activity radiobrominated pharmaceuticals for PET studies
  20. [123/131I]Iodometomidate as a radioligand for functional diagnosis of adrenal disease: synthesis, structural requirements and biodistribution
  21. Synthesis of [123I]iodine labelled imidazo[1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT
  22. Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T
  23. Chemoselective pre-conjugate radiohalogenation of unprotected mono- and multimeric peptides via oxime formation
  24. A rapid, almost quantitative conversion of [11C]carbon dioxide into [11C]carbon monoxide via [11C]formate and [11C]formyl chloride
  25. Radiosynthesis of (N-[11C]methyl)benperidol for PET investigation of D2 receptor binding
  26. Determination of reaction parameters for the synthesis of the serotonin transporter ligand [11C]DASB: Application to a remotely controlled high yield synthesis
  27. Radiosynthesis and in vitro evaluation of the 5HT2 receptor ligand [N-11C-methyl]-1-[2,5-dimethoxy-4-iodophenyl]-2-methylaminopropane for PET
  28. Synthesis of 4-([18F]fluoromethyl)-2-chlorophenylisothiocyanate: A novel bifunctional 18F-labelling agent
  29. Isotopic tracer studies of chemical behavior of rare earth elements in environmental and biological sciences
  30. A new technique for radiolabelling of humic substances
  31. Trace elements evaluation of some medicinal herbs by instrumental neutron activation analysis
  32. Ultratrace and isotope ratios analyses of some radionuclides by ICP-MS
  33. The study of natural radionuclides and radon exhalation rate in ceramic materials containing fly ash developed in Israel
https://doi.org/10.1524/ract.92.4.237.35596

Articles in the same Issue

  1. Gerhard L. Stöcklin Memorial Issue. Dedication and Appreciation
  2. In Memoriam Gerhard L. Stöcklin
  3. From hot atom chemistry to epithermal chemistry
  4. Excitation functions of deuteron induced nuclear reactions on enriched 78Kr with particular relevance to the production of 76Br
  5. Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
  6. Cross section measurements of proton and deuteron induced formation of 103Ag in natural palladium
  7. The Auger-electron emitter 165Er: excitation function of the 165Ho(p,n)165Er process
  8. Cross sections for production of the therapeutic radioisotopes 198Au and 199Au in proton and deuteron induced reactions on 198Pt
  9. Production of 16N for instrument calibration
  10. New determination of the half-life of 205Bi
  11. Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility
  12. A no-carrier-added 72Se/72As radionuclide generator based on distillation
  13. The isolation of 99Mo from fission material for use in the 99Mo/99mTc generator for medical use
  14. 99mTc gel generators based on zirconium molybdate-99Mo: III: Influence of preparatory conditions of zirconium molybdate-99Mo gel on generator performance
  15. Structure of [N,N´-bis(3,5-di-t-butyl-salicylidene)-2-benzyl-1,3-propanediaminato]nitridotechnetium(V) complex, TcN(bzdbsalpn), and nitrido-bridged linear polymeric chains in crystalline syn-isomer
  16. Neutral oxorhenium(V) and oxotechnetium(V) complexes with novel amide thioether dithiolate ligands derived from cysteine
  17. 188Re(V)-DMSA: in-vitro and in-vivo studies on the individual stereo isomers
  18. Analysis of 188Re-EDTMP complexes by HPLC and ultrafiltration
  19. Semi-remote production of Br-76 and preparation of high specific activity radiobrominated pharmaceuticals for PET studies
  20. [123/131I]Iodometomidate as a radioligand for functional diagnosis of adrenal disease: synthesis, structural requirements and biodistribution
  21. Synthesis of [123I]iodine labelled imidazo[1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT
  22. Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T
  23. Chemoselective pre-conjugate radiohalogenation of unprotected mono- and multimeric peptides via oxime formation
  24. A rapid, almost quantitative conversion of [11C]carbon dioxide into [11C]carbon monoxide via [11C]formate and [11C]formyl chloride
  25. Radiosynthesis of (N-[11C]methyl)benperidol for PET investigation of D2 receptor binding
  26. Determination of reaction parameters for the synthesis of the serotonin transporter ligand [11C]DASB: Application to a remotely controlled high yield synthesis
  27. Radiosynthesis and in vitro evaluation of the 5HT2 receptor ligand [N-11C-methyl]-1-[2,5-dimethoxy-4-iodophenyl]-2-methylaminopropane for PET
  28. Synthesis of 4-([18F]fluoromethyl)-2-chlorophenylisothiocyanate: A novel bifunctional 18F-labelling agent
  29. Isotopic tracer studies of chemical behavior of rare earth elements in environmental and biological sciences
  30. A new technique for radiolabelling of humic substances
  31. Trace elements evaluation of some medicinal herbs by instrumental neutron activation analysis
  32. Ultratrace and isotope ratios analyses of some radionuclides by ICP-MS
  33. The study of natural radionuclides and radon exhalation rate in ceramic materials containing fly ash developed in Israel
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