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The isolation of 99Mo from fission material for use in the 99Mo/99mTc generator for medical use

  • T.N. van der Walt and P. P. Coetzee
Published/Copyright: September 25, 2009
Radiochimica Acta
From the journal Radiochimica Acta Volume 92 Issue 4-6

Abstract

Molybdenum-99 is an important radionuclide which is used in nuclear medicine and a new method is presented for the isolation and purification of 99Mo from fission material. The method was developed to suit the needs of the Nuclear Energy Corporation of South Africa (NECSA) and also because most other methods had been patented and could therefore not be used at NECSA. A uranium-aluminium alloy, cladded in aluminium, served as a target and the target was irradiated in a nuclear reactor for several days. After a cooling period, in order to let the short-lived radionuclides decay, the target material was dissolved in a sodium hydroxide solution. The radioactive krypton and xenon gases were collected on activated carbon and stored until both gases had decayed. Aluminium, 99Mo, 131I and the radionuclides of alkali-soluble elements in the sodium hydroxide solution were separated from the uranium and radionuclides of the alkaline-insoluble elements by filtration. The radionuclides of molybdenum and iodine were separated by anion exchange chromatography, in alkaline medium, from the bulk aluminium and radionuclides of other elements, such as barium, strontium and tellurium. 99Mo was selectively eluted with a slightly alkaline lithium sulphate solution, leaving the iodine radionuclides on the resin. The 99Mo eluant was acidified with oxalic acid and nitric acid and 99Mo separated from the remaining aluminium and other radionuclides by anion exchange chromatography, in acid medium. After elution of 99Mo, again with a slightly alkaline lithium sulphate solution, the eluant was acidified with nitric acid, 99Mo concentrated on a chelating resin column and finally eluted with ammonia and evaporated to obtain 99MoO3 which was then dissolved in diluted sodium hydroxide solution. The purity of the final product was within the specifications of the British and European Pharmacopoiea and no further purification steps, such as sublimation, were required.

Published Online: 2009-9-25
Published in Print: 2004-4-1

© 2004 Oldenbourg Wissenschaftsverlag GmbH

Articles in the same Issue

  1. Gerhard L. Stöcklin Memorial Issue. Dedication and Appreciation
  2. In Memoriam Gerhard L. Stöcklin
  3. From hot atom chemistry to epithermal chemistry
  4. Excitation functions of deuteron induced nuclear reactions on enriched 78Kr with particular relevance to the production of 76Br
  5. Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
  6. Cross section measurements of proton and deuteron induced formation of 103Ag in natural palladium
  7. The Auger-electron emitter 165Er: excitation function of the 165Ho(p,n)165Er process
  8. Cross sections for production of the therapeutic radioisotopes 198Au and 199Au in proton and deuteron induced reactions on 198Pt
  9. Production of 16N for instrument calibration
  10. New determination of the half-life of 205Bi
  11. Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility
  12. A no-carrier-added 72Se/72As radionuclide generator based on distillation
  13. The isolation of 99Mo from fission material for use in the 99Mo/99mTc generator for medical use
  14. 99mTc gel generators based on zirconium molybdate-99Mo: III: Influence of preparatory conditions of zirconium molybdate-99Mo gel on generator performance
  15. Structure of [N,N´-bis(3,5-di-t-butyl-salicylidene)-2-benzyl-1,3-propanediaminato]nitridotechnetium(V) complex, TcN(bzdbsalpn), and nitrido-bridged linear polymeric chains in crystalline syn-isomer
  16. Neutral oxorhenium(V) and oxotechnetium(V) complexes with novel amide thioether dithiolate ligands derived from cysteine
  17. 188Re(V)-DMSA: in-vitro and in-vivo studies on the individual stereo isomers
  18. Analysis of 188Re-EDTMP complexes by HPLC and ultrafiltration
  19. Semi-remote production of Br-76 and preparation of high specific activity radiobrominated pharmaceuticals for PET studies
  20. [123/131I]Iodometomidate as a radioligand for functional diagnosis of adrenal disease: synthesis, structural requirements and biodistribution
  21. Synthesis of [123I]iodine labelled imidazo[1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT
  22. Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T
  23. Chemoselective pre-conjugate radiohalogenation of unprotected mono- and multimeric peptides via oxime formation
  24. A rapid, almost quantitative conversion of [11C]carbon dioxide into [11C]carbon monoxide via [11C]formate and [11C]formyl chloride
  25. Radiosynthesis of (N-[11C]methyl)benperidol for PET investigation of D2 receptor binding
  26. Determination of reaction parameters for the synthesis of the serotonin transporter ligand [11C]DASB: Application to a remotely controlled high yield synthesis
  27. Radiosynthesis and in vitro evaluation of the 5HT2 receptor ligand [N-11C-methyl]-1-[2,5-dimethoxy-4-iodophenyl]-2-methylaminopropane for PET
  28. Synthesis of 4-([18F]fluoromethyl)-2-chlorophenylisothiocyanate: A novel bifunctional 18F-labelling agent
  29. Isotopic tracer studies of chemical behavior of rare earth elements in environmental and biological sciences
  30. A new technique for radiolabelling of humic substances
  31. Trace elements evaluation of some medicinal herbs by instrumental neutron activation analysis
  32. Ultratrace and isotope ratios analyses of some radionuclides by ICP-MS
  33. The study of natural radionuclides and radon exhalation rate in ceramic materials containing fly ash developed in Israel
https://doi.org/10.1524/ract.92.4.251.35589

Articles in the same Issue

  1. Gerhard L. Stöcklin Memorial Issue. Dedication and Appreciation
  2. In Memoriam Gerhard L. Stöcklin
  3. From hot atom chemistry to epithermal chemistry
  4. Excitation functions of deuteron induced nuclear reactions on enriched 78Kr with particular relevance to the production of 76Br
  5. Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
  6. Cross section measurements of proton and deuteron induced formation of 103Ag in natural palladium
  7. The Auger-electron emitter 165Er: excitation function of the 165Ho(p,n)165Er process
  8. Cross sections for production of the therapeutic radioisotopes 198Au and 199Au in proton and deuteron induced reactions on 198Pt
  9. Production of 16N for instrument calibration
  10. New determination of the half-life of 205Bi
  11. Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility
  12. A no-carrier-added 72Se/72As radionuclide generator based on distillation
  13. The isolation of 99Mo from fission material for use in the 99Mo/99mTc generator for medical use
  14. 99mTc gel generators based on zirconium molybdate-99Mo: III: Influence of preparatory conditions of zirconium molybdate-99Mo gel on generator performance
  15. Structure of [N,N´-bis(3,5-di-t-butyl-salicylidene)-2-benzyl-1,3-propanediaminato]nitridotechnetium(V) complex, TcN(bzdbsalpn), and nitrido-bridged linear polymeric chains in crystalline syn-isomer
  16. Neutral oxorhenium(V) and oxotechnetium(V) complexes with novel amide thioether dithiolate ligands derived from cysteine
  17. 188Re(V)-DMSA: in-vitro and in-vivo studies on the individual stereo isomers
  18. Analysis of 188Re-EDTMP complexes by HPLC and ultrafiltration
  19. Semi-remote production of Br-76 and preparation of high specific activity radiobrominated pharmaceuticals for PET studies
  20. [123/131I]Iodometomidate as a radioligand for functional diagnosis of adrenal disease: synthesis, structural requirements and biodistribution
  21. Synthesis of [123I]iodine labelled imidazo[1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT
  22. Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T
  23. Chemoselective pre-conjugate radiohalogenation of unprotected mono- and multimeric peptides via oxime formation
  24. A rapid, almost quantitative conversion of [11C]carbon dioxide into [11C]carbon monoxide via [11C]formate and [11C]formyl chloride
  25. Radiosynthesis of (N-[11C]methyl)benperidol for PET investigation of D2 receptor binding
  26. Determination of reaction parameters for the synthesis of the serotonin transporter ligand [11C]DASB: Application to a remotely controlled high yield synthesis
  27. Radiosynthesis and in vitro evaluation of the 5HT2 receptor ligand [N-11C-methyl]-1-[2,5-dimethoxy-4-iodophenyl]-2-methylaminopropane for PET
  28. Synthesis of 4-([18F]fluoromethyl)-2-chlorophenylisothiocyanate: A novel bifunctional 18F-labelling agent
  29. Isotopic tracer studies of chemical behavior of rare earth elements in environmental and biological sciences
  30. A new technique for radiolabelling of humic substances
  31. Trace elements evaluation of some medicinal herbs by instrumental neutron activation analysis
  32. Ultratrace and isotope ratios analyses of some radionuclides by ICP-MS
  33. The study of natural radionuclides and radon exhalation rate in ceramic materials containing fly ash developed in Israel
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