Home Physical Sciences Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
Article
Licensed
Unlicensed Requires Authentication

Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM

  • Toshimitsu Fukumura , Kazuhiro Okada , Ferenc Szelecsényi , Zoltán Kovács and Kazutoshi Suzuki
Published/Copyright: September 25, 2009
Radiochimica Acta
From the journal Radiochimica Acta Volume 92 Issue 4-6

Abstract

Copper-61 (T1/2=3.41 h) produced via the 59Co(α,2n)61Cu nuclear reaction using natural Co target was isolated from the irradiated target by two methods developed here and applied for preparation of (61Cu-ATSM) (61Cu-diacetyl-bis(N4-methylthiosemicarbazone)), known as an imaging agent of hypoxic tissue. A commercially available cobalt disk (thickness: 125 μm) was irradiated with 40 MeV (37.9 MeV on target) α particles, then treated with conc. HNO3, and the 61Cu was separated by two different methods, i.e. a two column method using a cation and an anion exchange column; and a one column method using a column packed with chelating resin, Chelex 100. Both separation methods gave satisfactory results, though the latter method was superior because of the simplicity of the apparatus, the separation procedure and somewhat shorter processing time. Around 1.1 GBq of 61Cu2+ were obtained with >95% yield (decay corrected) from Co target at 10 μA for 1 h irradiation, and with the radionuclidic purity of >98% (EOS). The only radionuclidic impurity in the isolated 61Cu2+ solution was identified to be 60Cu at EOS but no radionuclidic impurity was observed after 50 hours. The solution of 61Cu-ATSM was prepared in >85% radiochemical yield with >95% radiochemical purity.

Published Online: 2009-9-25
Published in Print: 2004-4-1

© 2004 Oldenbourg Wissenschaftsverlag GmbH

Articles in the same Issue

  1. Gerhard L. Stöcklin Memorial Issue. Dedication and Appreciation
  2. In Memoriam Gerhard L. Stöcklin
  3. From hot atom chemistry to epithermal chemistry
  4. Excitation functions of deuteron induced nuclear reactions on enriched 78Kr with particular relevance to the production of 76Br
  5. Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
  6. Cross section measurements of proton and deuteron induced formation of 103Ag in natural palladium
  7. The Auger-electron emitter 165Er: excitation function of the 165Ho(p,n)165Er process
  8. Cross sections for production of the therapeutic radioisotopes 198Au and 199Au in proton and deuteron induced reactions on 198Pt
  9. Production of 16N for instrument calibration
  10. New determination of the half-life of 205Bi
  11. Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility
  12. A no-carrier-added 72Se/72As radionuclide generator based on distillation
  13. The isolation of 99Mo from fission material for use in the 99Mo/99mTc generator for medical use
  14. 99mTc gel generators based on zirconium molybdate-99Mo: III: Influence of preparatory conditions of zirconium molybdate-99Mo gel on generator performance
  15. Structure of [N,N´-bis(3,5-di-t-butyl-salicylidene)-2-benzyl-1,3-propanediaminato]nitridotechnetium(V) complex, TcN(bzdbsalpn), and nitrido-bridged linear polymeric chains in crystalline syn-isomer
  16. Neutral oxorhenium(V) and oxotechnetium(V) complexes with novel amide thioether dithiolate ligands derived from cysteine
  17. 188Re(V)-DMSA: in-vitro and in-vivo studies on the individual stereo isomers
  18. Analysis of 188Re-EDTMP complexes by HPLC and ultrafiltration
  19. Semi-remote production of Br-76 and preparation of high specific activity radiobrominated pharmaceuticals for PET studies
  20. [123/131I]Iodometomidate as a radioligand for functional diagnosis of adrenal disease: synthesis, structural requirements and biodistribution
  21. Synthesis of [123I]iodine labelled imidazo[1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT
  22. Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T
  23. Chemoselective pre-conjugate radiohalogenation of unprotected mono- and multimeric peptides via oxime formation
  24. A rapid, almost quantitative conversion of [11C]carbon dioxide into [11C]carbon monoxide via [11C]formate and [11C]formyl chloride
  25. Radiosynthesis of (N-[11C]methyl)benperidol for PET investigation of D2 receptor binding
  26. Determination of reaction parameters for the synthesis of the serotonin transporter ligand [11C]DASB: Application to a remotely controlled high yield synthesis
  27. Radiosynthesis and in vitro evaluation of the 5HT2 receptor ligand [N-11C-methyl]-1-[2,5-dimethoxy-4-iodophenyl]-2-methylaminopropane for PET
  28. Synthesis of 4-([18F]fluoromethyl)-2-chlorophenylisothiocyanate: A novel bifunctional 18F-labelling agent
  29. Isotopic tracer studies of chemical behavior of rare earth elements in environmental and biological sciences
  30. A new technique for radiolabelling of humic substances
  31. Trace elements evaluation of some medicinal herbs by instrumental neutron activation analysis
  32. Ultratrace and isotope ratios analyses of some radionuclides by ICP-MS
  33. The study of natural radionuclides and radon exhalation rate in ceramic materials containing fly ash developed in Israel
https://doi.org/10.1524/ract.92.4.209.35593

Articles in the same Issue

  1. Gerhard L. Stöcklin Memorial Issue. Dedication and Appreciation
  2. In Memoriam Gerhard L. Stöcklin
  3. From hot atom chemistry to epithermal chemistry
  4. Excitation functions of deuteron induced nuclear reactions on enriched 78Kr with particular relevance to the production of 76Br
  5. Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
  6. Cross section measurements of proton and deuteron induced formation of 103Ag in natural palladium
  7. The Auger-electron emitter 165Er: excitation function of the 165Ho(p,n)165Er process
  8. Cross sections for production of the therapeutic radioisotopes 198Au and 199Au in proton and deuteron induced reactions on 198Pt
  9. Production of 16N for instrument calibration
  10. New determination of the half-life of 205Bi
  11. Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility
  12. A no-carrier-added 72Se/72As radionuclide generator based on distillation
  13. The isolation of 99Mo from fission material for use in the 99Mo/99mTc generator for medical use
  14. 99mTc gel generators based on zirconium molybdate-99Mo: III: Influence of preparatory conditions of zirconium molybdate-99Mo gel on generator performance
  15. Structure of [N,N´-bis(3,5-di-t-butyl-salicylidene)-2-benzyl-1,3-propanediaminato]nitridotechnetium(V) complex, TcN(bzdbsalpn), and nitrido-bridged linear polymeric chains in crystalline syn-isomer
  16. Neutral oxorhenium(V) and oxotechnetium(V) complexes with novel amide thioether dithiolate ligands derived from cysteine
  17. 188Re(V)-DMSA: in-vitro and in-vivo studies on the individual stereo isomers
  18. Analysis of 188Re-EDTMP complexes by HPLC and ultrafiltration
  19. Semi-remote production of Br-76 and preparation of high specific activity radiobrominated pharmaceuticals for PET studies
  20. [123/131I]Iodometomidate as a radioligand for functional diagnosis of adrenal disease: synthesis, structural requirements and biodistribution
  21. Synthesis of [123I]iodine labelled imidazo[1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT
  22. Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T
  23. Chemoselective pre-conjugate radiohalogenation of unprotected mono- and multimeric peptides via oxime formation
  24. A rapid, almost quantitative conversion of [11C]carbon dioxide into [11C]carbon monoxide via [11C]formate and [11C]formyl chloride
  25. Radiosynthesis of (N-[11C]methyl)benperidol for PET investigation of D2 receptor binding
  26. Determination of reaction parameters for the synthesis of the serotonin transporter ligand [11C]DASB: Application to a remotely controlled high yield synthesis
  27. Radiosynthesis and in vitro evaluation of the 5HT2 receptor ligand [N-11C-methyl]-1-[2,5-dimethoxy-4-iodophenyl]-2-methylaminopropane for PET
  28. Synthesis of 4-([18F]fluoromethyl)-2-chlorophenylisothiocyanate: A novel bifunctional 18F-labelling agent
  29. Isotopic tracer studies of chemical behavior of rare earth elements in environmental and biological sciences
  30. A new technique for radiolabelling of humic substances
  31. Trace elements evaluation of some medicinal herbs by instrumental neutron activation analysis
  32. Ultratrace and isotope ratios analyses of some radionuclides by ICP-MS
  33. The study of natural radionuclides and radon exhalation rate in ceramic materials containing fly ash developed in Israel
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2026 De Gruyter Brill
Downloaded on 1.2.2026 from https://www.degruyterbrill.com/document/doi/10.1524/ract.92.4.209.35593/html
Scroll to top button