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In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera

  • Salha M. Aljubiri ORCID logo EMAIL logo , Eman Abd Elsalam , Faten K. Abd El Hady , Mohamed O. Radwan ORCID logo , Abdulrahman I. Almansour and Kamel H. Shaker
Published/Copyright: November 3, 2022
Zeitschrift für Naturforschung C
From the journal Zeitschrift für Naturforschung C Volume 78 Issue 5-6

Abstract

Acetylcholinesterase, tyrosinase, and α-glucosidase inhibition activities of Euphorbia schimperiana and Euphorbia balsamifera extracts, fractions, and available pure compounds were evaluated for the first time. Acetylcholinesterase assay revealed a significant inhibitory activity of E. balsamifera total extract and n-hexane fraction with 47.7% and 43.3%, respectively, compared to the reference drug, which was 75%. The n-butanol fraction demonstrated tyrosinase inhibitory activity for E. balsamifera and E. schimperiana with 36.7% and 29.7%, respectively, compared to 60% for the reference drug. Quercetin-3-O-α-glucuronide, quercetin-3-O-β-D-glucuronide-methyl ester, quercetin-3-O-α-L-rhamnoside, 3,3′-di-O-methyl ellagic acid, 3,3′-di-O-methyl-ellagic acid-4-β-D-xylopyranoside, and 4-O-ethyl gallic acid were identified from E. schimperiana while quercetin-3-O-glucopyranoside and isoorientin were determined from E. balsamifera. The AChE inhibitory effect of pure compounds exhibited promising activity, where 4-O-ethylgallic acid demonstrated 51.1%, while the highest tyrosinase inhibition was demonstrated by isoorientin with 50.6% compared to the reference drug (60%). Finally, a molecular docking study was performed for the most promising AChE and tyrosinase inhibitors. The extracts, fractions, and isolated compounds showed no α-glucosidase inhibitory activity.

Keywords: Acetylcholinesterase; Euphorbia balsamifera ; Euphorbia schimperiana ; molecular docking; tyrosinase
Corresponding author: Salha M. Aljubiri, Department of Chemistry, College of Science, University of Bisha, Bisha 61922, P.O. Box 551, Saudi Arabia; and Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia, E-mail:

Funding source: Deanship of scientific research in King Saud University

Award Identifier / Grant number: The initiative of DSR Graduate Students Research Support (GSR)

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was funded by Deanship of scientific research in King Saud University and supporting this research through the initiative of DSR Graduate Students Research Support (GSR).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2021-06-22
Accepted: 2022-10-14
Published Online: 2022-11-03
Published in Print: 2023-05-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Research Articles
  3. A novel eudesmol derivative from the leaf essential oil of Guatteria friesiana (Annonaceae) and evaluation of the antinociceptive activity
  4. Chemical constituents of Desmodium triflorum and their antifungal activity against various phytopathogenic fungi
  5. Exploring phytochemical constituents of Achillea arabica Kotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats
  6. Chemical constituents from Ficus sur Forssk (Moraceae)
  7. In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera
  8. Furoquinoline and bisindole alkaloids from the roots of Teclea nobilis and their in-silico molecular docking analysis
  9. Limonoids and insecticidal activity on Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) of Trichilia catigua A. Juss. (Meliaceae)
  10. Tissue specific changes of phytochemicals, antioxidant, antidiabetic and anti-inflammatory activities of tea [Camellia sinensis (L.)] extracted with different solvents
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https://doi.org/10.1515/znc-2021-0178
Keywords for this article
Acetylcholinesterase; Euphorbia balsamifera; Euphorbia schimperiana; molecular docking; tyrosinase

Articles in the same Issue

  1. Frontmatter
  2. Research Articles
  3. A novel eudesmol derivative from the leaf essential oil of Guatteria friesiana (Annonaceae) and evaluation of the antinociceptive activity
  4. Chemical constituents of Desmodium triflorum and their antifungal activity against various phytopathogenic fungi
  5. Exploring phytochemical constituents of Achillea arabica Kotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats
  6. Chemical constituents from Ficus sur Forssk (Moraceae)
  7. In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera
  8. Furoquinoline and bisindole alkaloids from the roots of Teclea nobilis and their in-silico molecular docking analysis
  9. Limonoids and insecticidal activity on Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) of Trichilia catigua A. Juss. (Meliaceae)
  10. Tissue specific changes of phytochemicals, antioxidant, antidiabetic and anti-inflammatory activities of tea [Camellia sinensis (L.)] extracted with different solvents
  11. Anonazepine, a new alkaloid from the leaves of Annona muricata (Annonaceae)
  12. Two new natural products from Portulaca oleracea L. and their bioactivities
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