human monoamine oxidase (hMAO) A and hMAO B inhibitors from Artemisia dracunculus L. herniarin and skimmin: human mononamine oxidase A and B inhibitors from A. dracunculus L.
-
Tuba Aydin
,
Hulya Akincioglu
,
Mehmet Gumustas
,
Ilhami Gulcin
,
Cavit Kazaz
and
Ahmet Cakir
Abstract
The aim of this study was to investigate the effects of extracts and pure Artemisia dracunculus L. (tarragon) metabolites on the antimonoamine oxidase and anticholinesterase activities. The compounds were characterized as stigmasterol (1), herniarin (2), (2E,4E)-1-(piperidin-1-yl)undeca-2,4-diene-8,10-diyn-1-one (3), (2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide (4), 3,4-dehydroherniarin (5) and skimmin (6) by 1H-NMR, 13C-NMR, 1D and 2D NMR methods. The compounds 5 and 6 were isolated from tarragon for the first time. The extracts and pure compounds have inhibitory effects on the human monoamine oxidase (hMAO) A and B enzymes, whereas they did not exhibit any anticholinesterase activities. Among the tarragon compounds, only 2 and 6 compounds showed the inhibitory effects against hMAO A (IC50 = 51.76 and 73.47 μM, respectively) and hMAO B (IC50 = 0.84 and 1.63 mM, respectively). In the study, herniarin content in the extracts was also analysed by high-performance liquid chromatography and it was found that there was a relationship between the inhibition effects of the extracts and their herniarin content.
Funding source: Ağrı İbrahim Çeçen University Research Fund
Award Identifier / Grant number: BAP: ECZF.18.002BAP: FEF.18.003
Acknowledgments
This study was supported by grants of Ağrı İbrahim Çeçen University Research Fund (BAP: ECZF.18.002 and BAP: FEF.18.003).
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
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- human monoamine oxidase (hMAO) A and hMAO B inhibitors from Artemisia dracunculus L. herniarin and skimmin: human mononamine oxidase A and B inhibitors from A. dracunculus L.
- Rapid communications
- Chemical composition and anticholinesterase inhibitory activity of Pavetta graciliflora Wall. ex Ridl. essential oil
- Chemical composition of the essential oils of four Polyalthia species from Malaysia
- Composition of the essential oils of three Malaysian Xylopia species (Annonaceae)
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Articles in the same Issue
- Frontmatter
- Research articles
- Modulation of antibiotic resistance by the essential oil of Ocimum gratissimum L. in association with light-emitting diodes (LED) lights
- Dynamic analysis of the mathematical model of COVID-19 with demographic effects
- Biochemical evidences for M1-, M17- and M18-like aminopeptidases in marine invertebrates from Cuban coastline
- Hexanal inhalation affects cognition and anxiety-like behavior in mice
- Overexpression of a novel E3 ubiquitin ligase gene from Coptis chinensis Franch enhances drought tolerance in transgenic tobacco
- Topiroxostat ameliorates oxidative stress and inflammation in sepsis-induced lung injury
- A computational study of the interactions between anthocyans and cyclodextrins
- Chemical characterization of the lipids in femoral gland secretions of wild male tegu lizards, Salvator merianae (Squamata, Teiidae) in comparison with captive-bred males
- Metabolite profiling by means of GC-MS combined with principal component analyses of natural populations of Nectaroscordum siculum ssp. bulgaricum (Janka) Stearn
- human monoamine oxidase (hMAO) A and hMAO B inhibitors from Artemisia dracunculus L. herniarin and skimmin: human mononamine oxidase A and B inhibitors from A. dracunculus L.
- Rapid communications
- Chemical composition and anticholinesterase inhibitory activity of Pavetta graciliflora Wall. ex Ridl. essential oil
- Chemical composition of the essential oils of four Polyalthia species from Malaysia
- Composition of the essential oils of three Malaysian Xylopia species (Annonaceae)
- Chemical characterization of Goniothalamus macrophyllus and Goniothalamus malayanus leaves’ essential oils
- Effect of pH on xylitol production by Candida species from a prairie cordgrass hydrolysate
