Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp.
-
Huijeong Jeong
,
Youngwan Seo
,
Yeon-Ju Lee
Abstract
Six known compounds, namely two halisulfates 1 and 2 and four epidioxy sterols 3–6, were isolated from the marine sponge Coscinoderma sp. The structures of these compounds were confirmed by nuclear magnetic resonance (1H and 13C NMR) spectroscopy, and their antiplasmodial activities were determined against the chloroquine-resistant Dd2 strain of Plasmodium falciparum. The epidioxy steroids 3–6 all showed moderate to weak antiplasmodial activity, with IC50 values of 2.7 μM for (24S)-5α,8α-epidioxy-24-methylcholesta-6-en-3β-ol (3), 11.6 μM for 5α,8α-epidioxycholesta-6,24(28)-dien-3β-o1 (4), 2.33 μM for 5α,8α-epidioxy-24-methylcholesta-6,9(11)-24(28)-trien-3β-ol (5), and between 12 and 24 μM for 5α,8α-epidioxycholesta-6-en-3β-ol (6). In contrast, halisulfate 2 (1) was inactive, and halisulfate 1 (2) had an of IC50 value of about 24 μM.
Acknowledgments
This work was supported by a grant from the Ministry of Oceans and Fisheries, Republic of Korea. Dr. Young A Kim, Senior Researcher, Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea, is also highly acknowledged for identifying the sponge sample.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Research Articles
- Secondary metabolites from Penicillium sp. 8PKH isolated from deteriorated rice straws
- A new ursane-type triterpene oxoglucopyranoside from Crossopteryx febrifuga
- Fisetin effects on cell proliferation and apoptosis in glioma cells
- Cytotoxic and anti-inflammatory resorcinol and alkylbenzoquinone derivatives from the leaves of Ardisia sieboldii
- Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp.
- The Hordeum bulbosum 25S-18S rDNA region: comparison with Hordeum vulgare and other Triticeae
- Hepatoprotective activity of a purified methanol extract and saponins from the roots of Chenopodium bonus-henricus L.
Artikel in diesem Heft
- Frontmatter
- Research Articles
- Secondary metabolites from Penicillium sp. 8PKH isolated from deteriorated rice straws
- A new ursane-type triterpene oxoglucopyranoside from Crossopteryx febrifuga
- Fisetin effects on cell proliferation and apoptosis in glioma cells
- Cytotoxic and anti-inflammatory resorcinol and alkylbenzoquinone derivatives from the leaves of Ardisia sieboldii
- Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp.
- The Hordeum bulbosum 25S-18S rDNA region: comparison with Hordeum vulgare and other Triticeae
- Hepatoprotective activity of a purified methanol extract and saponins from the roots of Chenopodium bonus-henricus L.
