Abstract
Accumulating experimental data suggests a number of successful drug targets against epilepsy which eventually failed in the clinical setup. Mammalian target of rapamycin inhibitors, multi-drug resistance transporter inhibitors, cyclo-oxygenase-2 inhibitors, statins, etc. are the most promising and well studied among them. Drugs aiming at these targets produced beneficial response in most of the in vitro and in vivo seizure models. However, in certain situations, they have produced differential rather controversial results. Their effects varied with the seizure model, species, time and route of administration, different drugs from the same class, etc. This review emphasises on such drugs which presented with variability in their beneficial effects against seizures and epilepsy. This review critically summarises the preclinical evidence of these targets in the context of seizures and the probable reasons for their variability and clinical failures.
Conflict of interest statement: The authors have no conflict of interest to declare.
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Articles in the same Issue
- Frontmatter
- Accelerated aging and aging process in the brain
- Recent studies on cellular and molecular mechanisms in Alzheimer’s disease: focus on epigenetic factors and histone deacetylase
- The neurophysiology of working memory development: from childhood to adolescence and young adulthood
- Mothering under the influence: how perinatal drugs of abuse alter the mother-infant interaction
- The natural history of subependymal giant cell astrocytomas in tuberous sclerosis complex: a review
- Why do herpes simplex encephalitis and semantic dementia show a different pattern of semantic impairment in spite of their main common involvement within the anterior temporal lobes?
- Regenerative potential of secretome from dental stem cells: a systematic review of preclinical studies
- Understanding the controversial drug targets in epilepsy and pharmacoresistant epilepsy
- Population-based differences in immune system response contribute to an increased risk of schizophrenia in African migrants?
Articles in the same Issue
- Frontmatter
- Accelerated aging and aging process in the brain
- Recent studies on cellular and molecular mechanisms in Alzheimer’s disease: focus on epigenetic factors and histone deacetylase
- The neurophysiology of working memory development: from childhood to adolescence and young adulthood
- Mothering under the influence: how perinatal drugs of abuse alter the mother-infant interaction
- The natural history of subependymal giant cell astrocytomas in tuberous sclerosis complex: a review
- Why do herpes simplex encephalitis and semantic dementia show a different pattern of semantic impairment in spite of their main common involvement within the anterior temporal lobes?
- Regenerative potential of secretome from dental stem cells: a systematic review of preclinical studies
- Understanding the controversial drug targets in epilepsy and pharmacoresistant epilepsy
- Population-based differences in immune system response contribute to an increased risk of schizophrenia in African migrants?