Population-based differences in immune system response contribute to an increased risk of schizophrenia in African migrants?

References

Ananth, C.V., Misra, D.P., Demissie, K., and Smulian, J.C. (2001). Rates of preterm delivery among black women and white women in the United States over two decades: an age-period-cohort analysis. Am. J. Epidemiol. 154, 657–665.10.1093/aje/154.7.657Search in Google Scholar PubMed

Barreiro, L.B. and Quintana-Murci, L. (2010). From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat. Rev. Genet. 11, 17–30.10.1038/nrg2698Search in Google Scholar PubMed

Bayer, T.A., Falkai, P., and Maier, W. (1999). Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the “Two hit hypothesis.” J. Psychiatr. Res. 33, 543−548.10.1016/S0022-3956(99)00039-4Search in Google Scholar PubMed

Benros, M.E., Pedersen, M.G., Rasmussen, H., Eaton, W.W., Nordentoft, M., and Mortensen, P.B. (2014). A nationwide study on the risk of autoimmune diseases in individuals with a personal or a family history of schizophrenia and related psychosis. Am. J. Psychiatry 171, 218–226.10.1176/appi.ajp.2013.13010086Search in Google Scholar PubMed

Bloomfield, P.S., Selvaraj, S., Veronese, M., Rizzo, G., Bertoldo, A., Owen, D.R., Bloomfield, M.A.P., Bonoldi, I., Kalk, N., Turkheimer, F., et al. (2016). Microglial activity in people at ultra high risk of psychosis and in schizophrenia: an [¹¹C]PBR28 PET brain imaging study. Am. J. Psychiatry 173, 44–52.10.1176/appi.ajp.2015.14101358Search in Google Scholar PubMed PubMed Central

Bourque, F., van der Ven, E., and Malla, A. (2011). A meta-analysis of the risk for psychotic disorders among first- and second-generation immigrants. Psychol. Med. 41, 897–910.10.1017/S0033291710001406Search in Google Scholar PubMed

Bresnahan, M., Begg, M.D., Brown, A., Schaefer, C., Sohler, N., Insel, B., Vella, L., and Susser, E. (2007). Race and risk of schizophrenia in a US birth cohort: another example of health disparity? Int. J. Epidemiol. 36, 751–758.10.1093/ije/dym041Search in Google Scholar PubMed

Brunier, L., Bleterry, M., Merle, S., Derancourt, C., Polomat, K., Dehlinger, V., Deligny, C., Jean-Baptiste, G., Arfi, S., Banydeen, R., et al. (2017). Prevalence of rheumatoid arthritis in the French West Indies: results of the EPPPRA study in Martinique. Jt. Bone Spine 84, 455–461.10.1016/j.jbspin.2016.09.003Search in Google Scholar PubMed

Campbell, M.C. and Tishkoff, S.A. (2008). African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet 9, 403–433.10.1146/annurev.genom.9.081307.164258Search in Google Scholar PubMed PubMed Central

Canetta, S. and Sourander, A. (2014). Elevated maternal C-reactive protein and increased risk of schizophrenia in a national birth cohort. Am. J. Psychiatry 171, 960–968.10.1176/appi.ajp.2014.13121579Search in Google Scholar PubMed PubMed Central

Christian, L.M., Iams, J.D., Porter, K., and Glaser, R. (2012). Epstein-Barr virus reactivation during pregnancy and postpartum: effects of race and racial discrimination. Brain Behav. Immun. 26, 1280–1287.10.1016/j.bbi.2012.08.006Search in Google Scholar PubMed PubMed Central

Dowd, J.B., Zajacova, A., and Aiello, A.E. (2010). Predictors of inflammation in U.S. children aged 316 years. Am. J. Prev. Med. 39, 314–320.10.1016/j.amepre.2010.05.014Search in Google Scholar PubMed PubMed Central

Edelstein, L.C., Simon, L.M., Montoya, R.T., Holinstat, M., Chen, E.S., Bergeron, A., Kong, X., Nagalla, S., Mohandas, N., Cohen, D.E., et al. (2013). Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c. Nat. Med. 19, 1609–1616.10.1038/nm.3385Search in Google Scholar PubMed PubMed Central

Egerton, A., Howes, O.D., Houle, S., McKenzie, K., Valmaggia, L.R., Bagby, M.R., Tseng, H.-H., Bloomfield, M.A.P., Kenk, M., Bhattacharyya, S., et al. (2017). Elevated striatal dopamine function in immigrants and their children: a risk mechanism for psychosis. Schizophr. Bull. 43, 293–301.10.1093/schbul/sbw181Search in Google Scholar PubMed PubMed Central

Fearon, P. and Morgan, C. (2006). Environmental factors in schizophrenia: the role of migrant studies. Schizophr. Bull. 32, 405–408.10.1093/schbul/sbj076Search in Google Scholar PubMed PubMed Central

Frank, M.G., Thompson, B.M., Watkins, L.R., and Maier, S.F. (2012). Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses. Brain Behav. Immun. 26, 337–345.10.1016/j.bbi.2011.10.005Search in Google Scholar PubMed PubMed Central

Garcia-Bueno, B., Bioque, M., Mac-Dowell, K.S., Barcones, M.F., Martinez-Cengotitabengoa, M., Pina-Camacho, L., Rodriguez-Jimenez, R., Saiz, P.A., Castro, C., Lafuente, A., et al. (2014). Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: Toward an integrative inflammatory hypothesis of schizophrenia. Schizophr. Bull. 40, 376–387.10.1093/schbul/sbt001Search in Google Scholar PubMed PubMed Central

Goedhart, G., Van Eijsden, M., Van Der Wal, M.F., and Bonsel, G.J. (2008). Ethnic differences in preterm birth and its subtypes: the effect of a cumulative risk profile. BJOG Int. J. Obstet. Gynaecol. 115, 710–719.10.1111/j.1471-0528.2008.01682.xSearch in Google Scholar PubMed

Hanke, M.L., Powell, N.D., Stiner, L.M., Bailey, M.T., and Sheridan, J.F. (2012). Beta adrenergic blockade decreases the immunomodulatory effects of social disruption stress. Brain. Behav. Immun. 26, 1150–1159.10.1016/j.bbi.2012.07.011Search in Google Scholar PubMed PubMed Central

Hertz, R.P., Unger, A.N., Cornell, J.A., and Saunders, E. (2005). Racial disparities in hypertension prevalence, awareness, and management. Arch. Intern. Med. 165, 2098.10.1001/archinte.165.18.2098Search in Google Scholar PubMed

Hoeffding, L.K., Rosengren, A., Thygesen, J.H., Schmock, H., Werge, T., and Hansen, T. (2017). Evaluation of shared genetic susceptibility loci between autoimmune diseases and schizophrenia based on genome-wide association studies. Nord. J. Psychiatry 71, 20–25.10.1080/08039488.2016.1198420Search in Google Scholar PubMed

Holly, E.N., Debold, J.F., and Miczek, K.A. (2015). Increased mesocorticolimbic dopamine during acute and repeated social defeat stress: modulation by corticotropin releasing factor receptors in the ventral tegmental area. Psychopharmacology (Berl.) 232, 4469–4479.10.1007/s00213-015-4082-zSearch in Google Scholar PubMed PubMed Central

Howes, O.D. and McCutcheon, R. (2017). Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization. Transl. Psychiatry 7, e1024.10.1038/tp.2016.278Search in Google Scholar PubMed PubMed Central

Jones, A.L., Mowry, B.J., Pender, M.P., and Greer, J.M. (2005). Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis? Immunol. Cell Biol. 83, 9–17.10.1111/j.1440-1711.2005.01305.xSearch in Google Scholar PubMed

Kanchanatawan, B., Sirivichayakul, S., Ruxrungtham, K., Carvalho, A.F., Geffard, M., Ormstad, H., Andreson, G., and Maes, M. (2017). Deficit, but not nondeficit, schizophrenia is characterized by mucosa-associated activation of the tryptophan catabolite (TRYCAT) pathway with highly specific increases in IgA responses directed to picolinic, xanthurenic, and quinolinic acid. Mol Neurobiol., in press.10.1007/s12035-017-0417-6Search in Google Scholar PubMed

Karlsson, E.K., Kwiatkowski, D.P., and Sabeti, P.C. (2014). Natural selection and infectious disease in human populations. Nat. Rev. Genet. 15, 379–393.10.1038/nrg3734Search in Google Scholar PubMed PubMed Central

Khandaker, G., Pearson, R., Zammit, S., Lewis, G., and Jones, P.B. (2014). Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life. J. Am. Med. Assoc. Psychiatry 71, 1121–1128.10.1001/jamapsychiatry.2014.1332Search in Google Scholar PubMed PubMed Central

Kirch, D.G. (1993). Infection and autoimmunity as etiologic factors in schizophrenia: a review and reappraisal. Schizophr. Bull. 19, 355–370.10.1093/schbul/19.2.355Search in Google Scholar PubMed

Kirkpatrick, B. and Miller, B.J. (2013). Inflammation and schizophrenia. Schizophr. Bull. 39, 1174–1179.10.1093/schbul/sbt141Search in Google Scholar PubMed PubMed Central

Knuesel, I., Chicha, L., Britschgi, M., Schobel, S.A., Bodmer, M., Hellings, J.A., Toovey, S., and Prinssen, E.P. (2014). Maternal immune activation and abnormal brain development across CNS disorders. Nat. Rev. Neurol. 10, 643–660.10.1038/nrneurol.2014.187Search in Google Scholar PubMed

Lewis, T.T., Aiello, A.E., Leurgans, S., Kelly, J., and Barnes, L.L. (2010). Self-reported experiences of everyday discrimination are associated with elevated C-reactive protein levels in older African-American adults. Brain. Behav. Immun. 24, 438–443.10.1016/j.bbi.2009.11.011Search in Google Scholar PubMed PubMed Central

Li, X., Sundquist, J., and Sundquist, K. (2009). Risks of rheumatic diseases in first- and second-generation immigrants in Sweden: a nationwide followup study. Arthritis Rheum. 60,1588−1596.10.1002/art.24526Search in Google Scholar PubMed

MacGregor, A.J., Riste, L.K., Hazes, J.M., and Silman, A.J. (1994). Low prevalence of rheumatoid arthritis in black-Caribbeans compared with whites in inner city Manchester. Ann. Rheum. Dis. 53, 293–297.10.1136/ard.53.5.293Search in Google Scholar PubMed PubMed Central

McGrath, J.J., Burne, T.H., Féron, F., MacKay-Sim, A., and Eyles, D.W. (2010). Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update. Schizophr. Bull. 36, 1073–1078.10.1093/schbul/sbq101Search in Google Scholar PubMed PubMed Central

McKernan, D.P., Dennison, U., Gaszner, G., Cryan, J.F., and Dinan, T.G. (2011). Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype. Transl. Psychiatry 1, e36.10.1038/tp.2011.37Search in Google Scholar PubMed PubMed Central

Menon, R., Velez, D.R., Morgan, N., Lombardi, S.J., Fortunato, S.J., and Williams, S.M. (2008). Genetic regulation of amniotic fluid TNF-α and soluble TNF receptor concentrations affected by race and preterm birth. Hum. Genet. 124, 243–253.10.1007/s00439-008-0547-zSearch in Google Scholar PubMed

Metcalf, S.A., Jones, P.B., Nordstrom, T., Timonen, M., Mäki, P., Miettunen, J., Jääskeläinen, E., Järvelin, M.-R., Stochl, J., Murray, G.K., et al. (2017). Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: a prospective birth cohort study. Brain. Behav. Immun. 59, 253–259.10.1016/j.bbi.2016.09.008Search in Google Scholar PubMed PubMed Central

Nedelec, Y., Sanz, J., Baharian, G., Szpiech, Z.A., Pacis, A., Dumaine, A., Grenier, J.C., Freiman, A., Sams, A.J., Hebert, S., et al. (2016). Genetic ancestry and natural selection drive population differences in immune responses to pathogens. Cell 167, 657–669.10.1016/j.cell.2016.09.025Search in Google Scholar PubMed

Ness, R.B., Haggerty, C.L., Harger, G., and Ferrell, R. (2004). Differential distribution of allelic variants in cytokine genes among African Americans and white Americans. Am. J. Epidemiol. 160, 1033–1038.10.1093/aje/kwh325Search in Google Scholar PubMed

Netea, M.G., Wijmenga, C., and O’Neill, L.A. (2012). Genetic variation in Toll-like receptors and disease susceptibility. Nat. Immunol. 13, 535–542.10.1038/ni.2284Search in Google Scholar PubMed

Nguyen, D.P., Genc, M., Vardhana, S., Babula, O., Onderdonk, A., and Witkin, S.S. (2004). Ethnic differences of polymorphisms in cytokine and innate immune system genes in pregnant women. Obstet. Gynecol. 104, 293–300.10.1097/01.AOG.0000133486.85400.5eSearch in Google Scholar PubMed

Nosarti, C., Reichenberg, A., Murray, R.M., Cnattingius, S., Lambe, M.P., Yin, L., MacCabe, J., Rifkin, L., and Hultman, C.M. (2012). Preterm birth and psychiatric disorders in young adult life. Arch. Gen. Psychiatry 69, 610−617.10.1001/archgenpsychiatry.2011.1374Search in Google Scholar PubMed

Park, S.J., Lee, J.Y., Kim, S.J., Choi, S.-Y., Yune, T.Y., and Ryu, J.H. (2015). Toll-like receptor-2 deficiency induces schizophrenia-like behaviors in mice. Sci. Rep. 5, 8502.10.1038/srep08502Search in Google Scholar PubMed PubMed Central

Picklesimer, A.H., Jared, H.L., Moss, K., Offenbacher, S., Beck, J.D., and Boggess, K.A. (2008). Racial differences in C-reactive protein levels during normal pregnancy. Am. J. Obs. Gynecol. 199, 523.e1–523.e6.10.1016/j.ajog.2008.04.017Search in Google Scholar PubMed PubMed Central

Pouget, J.G., Gonçalves, V.F., Spain, S.L., Finucane, H.K., Raychaudhuri, S., Kennedy, J.L., and Knight, J. (2016). Genome-wide association studies suggest limited immune gene enrichment in schizophrenia compared to 5 autoimmune diseases. Schizophr. Bull. 42, 1176–1184.10.1093/schbul/sbw059Search in Google Scholar PubMed PubMed Central

Powell, N.D., Bailey, M.T., Mays, J.W., Stiner-Jones, L.M., Hanke, M.L., Padgett, D.A., and Sheridan, J.F. (2009). Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion. Brain. Behav. Immun. 23, 225–231.10.1016/j.bbi.2008.09.010Search in Google Scholar PubMed PubMed Central

Quach, H., Rotival, M., Pothlichet, J., Eddie Loh, Y.-H., Dannemann, M., Zidane, N., Laval, G., Patin, E., Harmant, C., Lopez, M., et al. (2016). Genetic adaptation and Neanderthal admixture shaped the immune system of human populations. Cell 167, 643–656.10.1016/j.cell.2016.09.024Search in Google Scholar PubMed PubMed Central

Radhakrishnan, R., Kaser, M., and Guloksuz, S. (2017). The link between the immune system, environment, and psychosis. Schizophr. Bull. 43, 693–697.10.1093/schbul/sbx057Search in Google Scholar PubMed PubMed Central

Ramos, P.S., Shedlock, A.M., and Langefeld, C.D. (2015). Genetics of autoimmune diseases: insights from population genetics. J. Hum. Genet. 60, 657–664.10.1038/jhg.2015.94Search in Google Scholar PubMed PubMed Central

Reiner, A.P., Beleza, S., Franceschini, N., Auer, P.L., Robinson, J.G., Kooperberg, C., Peters, U., and Tang, H. (2012). Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. Am. J. Hum. Genet. 91, 502–512.10.1016/j.ajhg.2012.07.023Search in Google Scholar PubMed PubMed Central

Rook, G.A.W., Raison, C.L., and Lowry, C.A. (2014). Microbial “old friends”, immunoregulation and socioeconomic status. Clin. Exp. Immunol. 177, 1–12.10.1111/cei.12269Search in Google Scholar PubMed PubMed Central

Schizophrenia Working Group of the Psychiatric Genomics Consortium. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427.10.1038/nature13595Search in Google Scholar PubMed PubMed Central

Schick, U.M., Auer, P.L., Bis, J.C., Lin, H., Wei, P., Pankratz, N., Lange, L.A., Brody, J., Stitziel, N.O., Kim, D.S., et al. (2015). Association of exome sequences with plasma C-reactive protein levels in >9000 participants. Hum. Mol. Genet. 24, 559–571.10.1093/hmg/ddu450Search in Google Scholar PubMed PubMed Central

Sekar, A., Bialas, A.R., de Rivera, H., Davis, A., Hammond, T.R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., et al. (2016). Schizophrenia risk from complex variation of complement component 4. Nature 530, 177–183.10.1038/nature16549Search in Google Scholar PubMed PubMed Central

Selten, J.P. and Cantor-Graae, E. (2005). Social defeat: risk factor for schizophrenia? Br. J. Psychiatry. 187, 101−102.10.1192/bjp.187.2.101Search in Google Scholar PubMed

Selten, J.P., Van Der Ven, E., Rutten, B.P.F., and Cantor-Graae, E. (2013). The social defeat hypothesis of schizophrenia: an update. Schizophr. Bull. 39, 1180–1186.10.1093/schbul/sbt134Search in Google Scholar PubMed PubMed Central

Snyder-Mackler, N., Sanz, J., Kohn, J.N., Brinkworth, J.F., Morrow, S., Shaver, A.O., Grenier, J.-C., Pique-Regi, R., Johnson, Z.P., Wilson, M.E., et al. (2016). Social status alters immune regulation and response to infection in macaques. Science 354, 1041–1045.10.1126/science.aah3580Search in Google Scholar PubMed PubMed Central

Teo, Y.Y., Small, K.S., and Kwiatkowski, D.P. (2010). Methodological challenges of genome-wide association analysis in Africa. Nat. Rev. Genet. 11, 149–160.10.1038/nrg2731Search in Google Scholar PubMed PubMed Central

Velasquez-Mieyer, P.A., Cowan, P.A., Perez-Faustinelli, S., Nieto-Martinez, R., Villegas-Barreto, C., Tolley, E.A., Lustig, R.H., and Alpert, B.S. (2008). Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents. Diabetes Care 31, 770–775.10.2337/dc07-1525Search in Google Scholar PubMed

Viatte, S., Flynn, E., Lunt, M., Barnes, J., Singwe-Ngandeu, M., Bas, S., Barton, A., and Gabay, C. (2012). Investigation of Caucasian rheumatoid arthritis susceptibility loci in African patients with the same disease. Arthritis Res. Ther. 14, R239.10.1186/ar4082Search in Google Scholar PubMed PubMed Central

Williams, D.R. and Earl, T.R. (2007). Commentary: Race and mental health – more questions than answers. Int. J. Epidemiol. 36, 758–760.10.1093/ije/dym114Search in Google Scholar PubMed