Startseite Population-based differences in immune system response contribute to an increased risk of schizophrenia in African migrants?
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Population-based differences in immune system response contribute to an increased risk of schizophrenia in African migrants?

  • Milica J. Nesic EMAIL logo und Nadja P. Maric
Veröffentlicht/Copyright: 18. November 2017
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Abstract

Among the highest incidences of schizophrenia is the one documented in second-generation migrants of African descent in the Western countries. Interestingly, people of African and European ancestry demonstrate significant genetic-based differences in immune system regulation and response. As a result, the pro-inflammatory phenotype is more pronounced in people of African descent than it is in Europeans. At the same time, the role of the immune system in the etiology of schizophrenia is gaining increased recognition. Here, we propose that the population-specific genetic variation within the immune system interacts with unfavourable environments to contribute to a higher risk of schizophrenia in people of African ancestry. Our hypothesis is supported by recent findings from two separate fields of research−population genetics and psychoneuroimmunology. Moreover, we highlight the need to include African populations in genetic studies of schizophrenia.

Acknowledgements

The authors wish to thank Prof. Dusan Popadic of the Institute of Microbiology and Immunology of Belgrade University School of Medicine for the comments that helped improve this article.

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Received: 2017-6-2
Accepted: 2017-8-5
Published Online: 2017-11-18
Published in Print: 2018-3-28

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