Startseite Naturwissenschaften Applications of samarium complexes as cytotoxic, bioimaging and DNA interacting agents: a comprehensive review
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Applications of samarium complexes as cytotoxic, bioimaging and DNA interacting agents: a comprehensive review

  • Poonam R. Inamdar ORCID logo EMAIL logo , Shashikant Bhandari , Mrunalini Kulkarni , Neeta Rai und Anuja Kolsure
Veröffentlicht/Copyright: 11. März 2024

Abstract

Cisplatin coined a term Metallodrug and later a tradition of Metallodrugs was established. Later, severe renal and metabolic toxicities of the platinum based drugs prompted the medicinal chemists to develop new and novel metallotherapeutics with different metal cores. Henceforth, chemists designed the metal complexes based on copper, cobalt, vanadium iron and zinc. These complexes were reported for their antibacterial, anticancer, antidiabetic and enzyme inhibitors. Later, chemists also focused on lanthanide metal ions and resulted in the design of metal complexes for the application of bio imaging cellular studies as well as chemotherapeutic agents. This review throws a light on the recent advances in the development of the samarium complexes as efficient and versatile biological agents. Samarium complexes based on various ligand systems and ancillary ligands have been mentioned in this review stating their biological efficacy and potency against variable cancer cell lines, their DNA interactive behaviour.


Corresponding author: Poonam R. Inamdar, Department of Pharmaceutical Sciences, School of Health Sciences and Technology, Dr. Vishwanath Karad MIT World Peace University, Pune, India, E-mail:

Acknowledgments

The authors are thankful to the Dean, Associate Dean, of Department of Pharmacy of MIT World Peace University, Pune. Maharashtra, India.

  1. Research ethics: Not applicable.

  2. Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors state no conflict of interest.

  4. Research funding: None declared.

  5. Data availability: Not applicable.

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Received: 2023-09-19
Accepted: 2024-01-22
Published Online: 2024-03-11
Published in Print: 2024-09-25

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 29.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/revic-2023-0026/html
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