Home Medicine Impacts and mechanisms of PM2.5 on bone
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Impacts and mechanisms of PM2.5 on bone

  • Yuqing Tian ORCID logo , Yunpeng Hu , Xiaoli Hou and Faming Tian EMAIL logo
Published/Copyright: August 3, 2023
Reviews on Environmental Health
From the journal Reviews on Environmental Health Volume 39 Issue 4

Abstract

Osteoporosis is a metabolic bone disease, which is characterized by a decreased bone mass and deterioration of bone microstructure, resulting in increased bone fragility and a higher risk of fracture. The main pathological process of osteoporosis is the dynamic imbalance between bone absorption and bone formation, which can be caused by various factors such as air pollution. Particulate matter (PM)2.5 refers to the fine particles in the atmosphere, which are small in volume and large in specific surface area. These particles are prone to carrying toxic substances and have negative effects on several extrapulmonary organs, including bones. In this review, we present relevant data from studies, which show that PM2.5 is associated with abnormal bone turnover and osteoporosis. PM2.5 may cause or aggravate bone loss by stimulating an inflammatory response, inducing oxidative damage, reducing estrogen efficiency by competitive binding to estrogen receptors, or endocrine disorder mediated by binding with aromatic hydrocarbon receptors, and affecting the synthesis of vitamin D to reduce calcium absorption. The cellular and molecular mechanisms involved in these processes are also summarized in this review.

Keywords: air pollution; bone; osteoblast; osteoclast; PM 2.5
Corresponding author: Faming Tian, MD, PhD, School of Public Health, North China University of Science and Technology, Bohai Road 21, Caofeidian Dis., Tangshan, 063210, China, Phone: +86 0315 8816230, E-mail:

Funding source: Youth Talent Support Program of Hebei Province

Award Identifier / Grant number: JI-2016-10

Funding source: Nation Nature Science Foundation of China

Award Identifier / Grant number: NSFC81874029

Funding source: Nature Science Foundation of Hebei Province

Award Identifier / Grant number: H2022209054

Funding source: Basic Scientific Research Funds Program of Universities in Hebei Province

Award Identifier / Grant number: JYG2021005

Funding source: Central Government-guided Local Science and Technology Development Foundation of Hebei Province

Award Identifier / Grant number: 226Z7709G

Acknowledgments

We thank Ellen Knapp, PhD, from Liwen Bianji (Edanz) (www.liwenbianji.cn/), for editing the English text of a draft of this manuscript.

  1. Ethical approval: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: Authors state no conflict of interest.

  5. Research funding: Nation Nature Science Foundation of China (NSFC81874029); Nature Science Foundation of Hebei Province (H2020209266; H2022209054); Basic Scientific Research Funds Program of Universities in Hebei Province (JYG2021005); Central Government-guided Local Science and Technology Development Foundation of Hebei Province (226Z7709G); Youth Talent Support Program of Hebei Province (JI-2016-10).

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Received: 2023-02-19
Accepted: 2023-06-28
Published Online: 2023-08-03
Published in Print: 2024-12-17

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. A systematic review on the association between exposure to air particulate matter during pregnancy and the development of hypertensive disorders of pregnancy and gestational diabetes mellitus
  4. Screen time and childhood attention deficit hyperactivity disorder: a meta-analysis
  5. The association between polycystic ovary syndrome and environmental pollutants based on animal and human study; a systematic review
  6. Residues of carcinogenic pesticides in food: a systematic review
  7. The concentration of Lithium in water resources: A systematic review, meta-analysis and health risk assessment
  8. Polychlorinated biphenyls and thyroid function: a scoping review
  9. The European Union assessments of radiofrequency radiation health risks – another hard nut to crack (Review)
  10. Research progresses on the effects of heavy metals on the circadian clock system
  11. Diagnosing and managing heat exhaustion: insights from a systematic review of cases in the desert climate of Mecca
  12. Para-occupational exposure to chemical substances: a systematic review
  13. Association of the ACE2-Angiotensin1-7–Mas axis with lung damage caused by cigarette smoke exposure: a systematic review
  14. Impacts and mechanisms of PM2.5 on bone
  15. Impacts and potential mechanisms of fine particulate matter (PM2.5) on male testosterone biosynthesis disruption
  16. Exposure to perfluoroalkyl and polyfluoroalkyl substances and risk of stroke in adults: a meta-analysis
  17. Prevalence and concentration of aflatoxin M1 and ochratoxin A in cheese: a global systematic review and meta-analysis and probabilistic risk assessment
  18. The effect of polycyclic aromatic hydrocarbon biomarkers on cardiovascular diseases
  19. Biological effects of electromagnetic fields on insects: a systematic review and meta-analysis
  20. Letter to the Editor
  21. Monkeypox and drug repurposing: seven potential antivirals to combat the viral disease
https://doi.org/10.1515/reveh-2023-0024
Keywords for this article
air pollution; bone; osteoblast; osteoclast; PM 2.5

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. A systematic review on the association between exposure to air particulate matter during pregnancy and the development of hypertensive disorders of pregnancy and gestational diabetes mellitus
  4. Screen time and childhood attention deficit hyperactivity disorder: a meta-analysis
  5. The association between polycystic ovary syndrome and environmental pollutants based on animal and human study; a systematic review
  6. Residues of carcinogenic pesticides in food: a systematic review
  7. The concentration of Lithium in water resources: A systematic review, meta-analysis and health risk assessment
  8. Polychlorinated biphenyls and thyroid function: a scoping review
  9. The European Union assessments of radiofrequency radiation health risks – another hard nut to crack (Review)
  10. Research progresses on the effects of heavy metals on the circadian clock system
  11. Diagnosing and managing heat exhaustion: insights from a systematic review of cases in the desert climate of Mecca
  12. Para-occupational exposure to chemical substances: a systematic review
  13. Association of the ACE2-Angiotensin1-7–Mas axis with lung damage caused by cigarette smoke exposure: a systematic review
  14. Impacts and mechanisms of PM2.5 on bone
  15. Impacts and potential mechanisms of fine particulate matter (PM2.5) on male testosterone biosynthesis disruption
  16. Exposure to perfluoroalkyl and polyfluoroalkyl substances and risk of stroke in adults: a meta-analysis
  17. Prevalence and concentration of aflatoxin M1 and ochratoxin A in cheese: a global systematic review and meta-analysis and probabilistic risk assessment
  18. The effect of polycyclic aromatic hydrocarbon biomarkers on cardiovascular diseases
  19. Biological effects of electromagnetic fields on insects: a systematic review and meta-analysis
  20. Letter to the Editor
  21. Monkeypox and drug repurposing: seven potential antivirals to combat the viral disease
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