Association of the ACE2-Angiotensin1-7–Mas axis with lung damage caused by cigarette smoke exposure: a systematic review

Maryam Maleki; Alireza Aliboroni; Amin Kheiri; Mohammad Reza Kaffashian; Maryam Kheiry

doi:10.1515/reveh-2023-0028

Article

Association of the ACE2-Angiotensin1-7–Mas axis with lung damage caused by cigarette smoke exposure: a systematic review

Maryam Maleki , Alireza Aliboroni , Amin Kheiri , Mohammad Reza Kaffashian and Maryam Kheiry

Published/Copyright: August 3, 2023

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From the journal Reviews on Environmental Health Volume 39 Issue 4

Abstract

Through the Mas receptor, angiotensin-(1-7) [Ang-(1-7)] has been shown to have a key role in the development of lung inflammation. This systematic review (SR) sought to identify the relationship between lung damage brought on by exposure to cigarette smoke (CS) and the ACE2-Ang-(1-7)–Mas pathway. In this investigation, relevant keywords were used to search PubMed (MEDLINE), Scopus (Elsevier), and Institute for Scientific Information (ISI) Web of Science up to December 2022. Nine studies were chosen because they satisfied the inclusion/exclusion criteria. The majority of research concluded that exposure to CS increased the risk of lung damage. Smoking cigarettes is the main cause of COPD because it causes massive amounts of reactive oxygen and nitrogen species to enter the lungs, which stimulate the production of inflammatory cytokines like IL-1 β, IL-6, and TNF-α, as well as the invasion of inflammatory cells like neutrophils and macrophages. These findings support the renin-angiotensin system’s (RAS) involvement in the pathophysiology of smoking-induced damage. Additionally, via stimulating pro-inflammatory mediators, aberrant RAS activity has been linked to lung damage. Lung inflammation’s etiology has been shown to be significantly influenced by the protective known RAS arm ACE2-Ang-(1-7)–Mas. In conclusion, these are important for informing policymakers to pass legislation limiting the use of smoking and other tobacco to prevent their harmful effects.

Keywords: ACE2; Angiotensin1-7; cigarette smoke; lung damage; Mas receptor

Corresponding author: Maryam Kheiry, Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran, Phone: +989120972638, E-mail: m.kheiry@yahoo.com.

Funding source: Ilam University of Medical Sciences, Ilam, Iran.

Award Identifier / Grant number: (Ethics ID: IR . MEDILAM .REC . 1401.145). not gra

Funding source: Ilam University of Medical Sciences, Ilam, Iran.

Award Identifier / Grant number: Unassigned

Acknowledgment

We acknowledge the assistance of Non-Communicable Diseases Research Center, Shahid Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran, during the process of this study.

Ethical approval: This study was a systematic review and did not use laboratory animals or human data in a laboratory manner and has an ethical code (Ethics ID: IR. MEDILAM.REC. 1401.145) from Ilam University of Medical Sciences.
Informed consent: Not applicable.
Author contribution: Maryam Maleki and Maryam Kheiry planned conducting the study, conceptualization, methodology, validation, formal analysis, investigation, supervision, writing – review & editing. Alireza Aliboroni was involved in conceptualization, validation, writing – review & editing. Amin Kheiri and Mohammad Reza Kaffashian participated in validation, writing – review & editing. All authors have made considerable contributions to acquisition and methodology, validation and preparing the manuscript of this study.
Competing interest: The authors declare no conflict of interests in this study.
Research funding: The funding organization played no role in the study design: in the collection, interpretation of data, in the writing of the report, in the decision to submit the report for publication. Ilam University of Medical Sciences, Ilam, Iran. (Ethics ID: IR . MEDILAM .REC . 1401.145). not gra; Ilam University of Medical Sciences, Ilam, Iran.

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Received: 2023-02-26

Accepted: 2023-06-19

Published Online: 2023-08-03

Published in Print: 2024-12-17

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Articles in the same Issue

https://doi.org/10.1515/reveh-2023-0028

Keywords for this article

ACE2; Angiotensin1-7; cigarette smoke; lung damage; Mas receptor