Polychlorinated biphenyls and thyroid function: a scoping review
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Pouria Mohammadparast-Tabas
und
Saeed Samarghandian
Abstract
Objective
Numerous evidence indicates the association between polychlorinated biphenyls (PCBs), an endocrine disrupter, with thyroid hormone disruption, contradictory findings also exist. Herein, we tried to address this question by performing a scoping review.
Content
The search was performed on PubMed, Scopus, Web of Science, and Google Scholar databases from 2010 onwards. Animal studies on PCBs’ effect on thyroid function were searched. The SYRCLE’s RoB scale assessed the risk of bias. I2 and Q tests are used for investigating heterogeneity. A random-effects model with the pooled standard means difference (SMD) and 95 % confidence interval (CI) was performed for the TSH, TT4, TT3, and FT4 outcomes using Comprehensive Meta-Analyses (CMA) Software version 3. Also, we conducted subgroup analyses based on the different types of PCB. The initial search identified 1,279 publications from the main databases 26 of them fulfilled our eligibility criteria for the study, and then five studies among selected studies had sufficient data for analysis. Meta-analysis of data revealed that Aroclor 1260 (SDM: −0.47, 95 % CI: −0.92, −0.01, p=0.044) and PCB 126 (SDM: 0.17, 95 % CI: −0.40, 0.75, p=0.559) significantly increased TSH concentration in the exposed groups vs. the control groups. Related to the effects of PCBs on the TT4, our findings indicated a significant reduction the TT4 concentration of animals exposed to Aroclor 1260 (SDM: −5.62, 95 % CI: −8.30, −2.94, p=0.0001), PCB 118 (SDM: −6.24, 95 % CI: −7.76, −4.72, p=0.0001), PCB 126 (SDM: −1.81, 95 % CI: −2.90, −0.71, p=0.001), and PCB 153 (SDM: −1.32, 95 % CI: −2.29, −0.35, p=0.007) vs. the controls. Our meta-analysis indicated a significant increase in TT3 concentration following exposure to PCB 118 and PCB 153 (SDM: −0.89, 95 % CI: −1.36, −0.42, p=0.0001, and SDM: −1.45, 95 % CI: −2.15, −0.75, p=0.0001, respectively). Aroclor 1254 and PCB 126 significantly decreased TT3 concentration (SDM: 1.25, 95 % CI: 0.29, 2.21, p=0.01 and SDM: 3.33, 95 % CI: 2.49, 4.18, p=0.0001, respectively). PCB 126 significantly decreased FT4 in the exposed groups vs. the control groups (SDM: −7.80, 95 % CI: −11.51, −5.35, p=0.0001).
Summary
Our findings showed an association between PCBs exposure and hypothyroidism in rodents, fish, and chicken embryos.
Outlook
Regarding to the most evidence of hypothyroidism effects of PCBs in animal species, it is necessary to consider large cohort studies to address the association between PCBs exposure and thyroid function impairment in humans.
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Research funding: Not applicable.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: Not applicable.
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Consent to participate: Not applicable
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Consent to publish: Not applicable
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Availability of data and materials: All data and materials are available in the main text.
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© 2023 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Reviews
- A systematic review on the association between exposure to air particulate matter during pregnancy and the development of hypertensive disorders of pregnancy and gestational diabetes mellitus
- Screen time and childhood attention deficit hyperactivity disorder: a meta-analysis
- The association between polycystic ovary syndrome and environmental pollutants based on animal and human study; a systematic review
- Residues of carcinogenic pesticides in food: a systematic review
- The concentration of Lithium in water resources: A systematic review, meta-analysis and health risk assessment
- Polychlorinated biphenyls and thyroid function: a scoping review
- The European Union assessments of radiofrequency radiation health risks – another hard nut to crack (Review)
- Research progresses on the effects of heavy metals on the circadian clock system
- Diagnosing and managing heat exhaustion: insights from a systematic review of cases in the desert climate of Mecca
- Para-occupational exposure to chemical substances: a systematic review
- Association of the ACE2-Angiotensin1-7–Mas axis with lung damage caused by cigarette smoke exposure: a systematic review
- Impacts and mechanisms of PM2.5 on bone
- Impacts and potential mechanisms of fine particulate matter (PM2.5) on male testosterone biosynthesis disruption
- Exposure to perfluoroalkyl and polyfluoroalkyl substances and risk of stroke in adults: a meta-analysis
- Prevalence and concentration of aflatoxin M1 and ochratoxin A in cheese: a global systematic review and meta-analysis and probabilistic risk assessment
- The effect of polycyclic aromatic hydrocarbon biomarkers on cardiovascular diseases
- Biological effects of electromagnetic fields on insects: a systematic review and meta-analysis
- Letter to the Editor
- Monkeypox and drug repurposing: seven potential antivirals to combat the viral disease
Artikel in diesem Heft
- Frontmatter
- Reviews
- A systematic review on the association between exposure to air particulate matter during pregnancy and the development of hypertensive disorders of pregnancy and gestational diabetes mellitus
- Screen time and childhood attention deficit hyperactivity disorder: a meta-analysis
- The association between polycystic ovary syndrome and environmental pollutants based on animal and human study; a systematic review
- Residues of carcinogenic pesticides in food: a systematic review
- The concentration of Lithium in water resources: A systematic review, meta-analysis and health risk assessment
- Polychlorinated biphenyls and thyroid function: a scoping review
- The European Union assessments of radiofrequency radiation health risks – another hard nut to crack (Review)
- Research progresses on the effects of heavy metals on the circadian clock system
- Diagnosing and managing heat exhaustion: insights from a systematic review of cases in the desert climate of Mecca
- Para-occupational exposure to chemical substances: a systematic review
- Association of the ACE2-Angiotensin1-7–Mas axis with lung damage caused by cigarette smoke exposure: a systematic review
- Impacts and mechanisms of PM2.5 on bone
- Impacts and potential mechanisms of fine particulate matter (PM2.5) on male testosterone biosynthesis disruption
- Exposure to perfluoroalkyl and polyfluoroalkyl substances and risk of stroke in adults: a meta-analysis
- Prevalence and concentration of aflatoxin M1 and ochratoxin A in cheese: a global systematic review and meta-analysis and probabilistic risk assessment
- The effect of polycyclic aromatic hydrocarbon biomarkers on cardiovascular diseases
- Biological effects of electromagnetic fields on insects: a systematic review and meta-analysis
- Letter to the Editor
- Monkeypox and drug repurposing: seven potential antivirals to combat the viral disease
