Production of Auger-electron-emitting 103mRh via a 103Pd/103mRh generator using an anion-exchange resin
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Tomoyuki Ohya
,
Jun Ichinose
,
Kotaro Nagatsu
Abstract
Rhodium-103m is one of the most attractive Auger electron emitters for internal radiotherapy. The half-life of 103mRh is relatively short (56.114 min). Therefore, it needs to be produced using a generator for clinical use. Most studies of 103Pd/103mRh generators using anion-exchange resins were carried out over 50 years ago. However, these resins are no longer commercially available. In the present study, we tested a 103Pd/103mRh generator using alternative anion-exchange resins (i.e., IRA904, IRA410, SA20A, and SA11AL). No-carrier-added 103Pd was used to make the generators. The 103mRh product was eluted from the generators using 6 mL of 0.1 M HCl with a flow rate 0.5 mL/min. The generator made from SA11AL showed good performance, with a yield of 39 %, an impurity level of 103Pd in the product of 0.29 %, and an operation time of 14 min. This makes this generator competitive with previously developed ones.
Acknowledgments
We thank the staff of RIPF, TIARA, CYRIC, especially Dr Yuki at Tohoku University for their support. We also acknowledge the speedy and kind support of the QST librarians. 103Pd was supplied by Supply Platform of Short-lived Radioisotopes, supported by JSPS Grant-in-Aid for Scientific Research on Innovative Areas, Grant Number 16H06278. This work was supported by JSPS KAKENHI, Grant Number JP23K07123. We thank Adam Brotchie, PhD, from Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.
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Research ethics: Not applicable.
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Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors state no conflict of interest.
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Research funding: JSPS KAKENHI, Grant Number JP23K07123. JSPS Grant-in-Aid for Scientific Research on Innovative Areas, Grant Number 16H06278.
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Data availability: The raw data can be obtained on request from the corresponding author.
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Articles in the same Issue
- Frontmatter
- Original Papers
- Efficient removal of U(VI) from aqueous solution by hydroxyapatite/graphene oxide composite microspheres
- Sorption behaviour of 137Cs and 152+154Eu onto bentonite phosphate modified with nickel: kinetics, isotherms, and chromatographic column application
- Inorganic composites based on carboxymethyl cellulose: preparation, characterization, sorption, and selectivity behavior for some radionuclides from radioactive solutions
- Production of Auger-electron-emitting 103mRh via a 103Pd/103mRh generator using an anion-exchange resin
- Determination of rare earth elements in Algerian bentonites using k0-NAA method
- Determination of natural and artificial radioactivity levels and radiation hazard indices for soil samples in Kırşehir
- Gamma-radiation levels along the main Karakorum thrust area of Northern Pakistan
Articles in the same Issue
- Frontmatter
- Original Papers
- Efficient removal of U(VI) from aqueous solution by hydroxyapatite/graphene oxide composite microspheres
- Sorption behaviour of 137Cs and 152+154Eu onto bentonite phosphate modified with nickel: kinetics, isotherms, and chromatographic column application
- Inorganic composites based on carboxymethyl cellulose: preparation, characterization, sorption, and selectivity behavior for some radionuclides from radioactive solutions
- Production of Auger-electron-emitting 103mRh via a 103Pd/103mRh generator using an anion-exchange resin
- Determination of rare earth elements in Algerian bentonites using k0-NAA method
- Determination of natural and artificial radioactivity levels and radiation hazard indices for soil samples in Kırşehir
- Gamma-radiation levels along the main Karakorum thrust area of Northern Pakistan
