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Evaluation of 186WS2 target material for production of high specific activity 186Re via proton irradiation: separation, radiolabeling and recovery/recycling

  • Anster Charles , Firouzeh Najafi Khosrashahi , Li Ma , Chathurya Munindradasa , Rebecca Hoerres , John D. Lydon , Steven P. Kelley , James Guthrie , David Rotsch , Dmitri Medvedev , Cathy S. Cutler , Yawen Li , D. Scott Wilbur , Heather M. Hennkens and Silvia S. Jurisson EMAIL logo
Published/Copyright: April 21, 2022
Radiochimica Acta
From the journal Radiochimica Acta Volume 110 Issue 6-9

Abstract

Enriched tungsten disulfide (186WS2) was evaluated at increasing proton beam currents (20–50 μA) and times (up to 4 h) on a GE PETtrace cyclotron for production of high specific activity (HSA) 186Re. The HSA 186Re was separated from the irradiated target as [186Re][ReO4]– by a liquid–liquid extraction method and radiolabeled with a new N2S2 ligand (222-MAMA-N-ethylpropionate). The enriched 186W was recovered from the extraction process, analyzed for purity and enrichment, and converted back to the disulfide (186WS2). The results demonstrate that the 186WS2 is an easily pressed target material that can withstand relatively high currents and can be readily recovered and recycled. The 186Re produced was isolated in high specific activity and readily formed the radiotracers [186Re][ReO(222-MAMA-N-ethylpropionate)] and [186Re][Re(CO)3(OH2)3] +.

Keywords: 186W(p,n)186Re; high specific activity (HSA) 186Re; N2S2 ligand (222-MAMA-N-ethylpropionate); ReO(222-MAMA-N-ethylpropionate); tungsten disulfide (WS2)
Corresponding author: Silvia S. Jurisson, Department of Chemistry, University of Missouri, Columbia, MO 65211, USA, E-mail:

Funding source: U.S. Department of EnergyOffice of ScienceNuclear PhysicsUniversity of Missouri

Award Identifier / Grant number: Unassigned

Award Identifier / Grant number: Unassigned

Award Identifier / Grant number: Unassigned

Award Identifier / Grant number: Unassigned

Acknowledgments

The authors thank Michael Hall at Essential Isotopes, LLC and Alex Saale at MURR for their assistance with the target irradiations.

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The authors gratefully acknowledge support from the U.S. Department of Energy Isotope Program, managed by the Office of Science for Nuclear Physics under grant DE-SC0018662 (SSJ). This work was supported in part by University of Missouri (MU) Tier 2 funds (HMH/SSJ) and MU Life Sciences Fellowship (AC).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/ract-2021-1138).

Received: 2021-12-14
Revised: 2022-01-28
Accepted: 2022-01-31
Published Online: 2022-04-21
Published in Print: 2022-06-27

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

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  2. Editorial: Diamond Jubilee Issue
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  28. Evaluation of 186WS2 target material for production of high specific activity 186Re via proton irradiation: separation, radiolabeling and recovery/recycling
  29. Special radionuclide production activities – recent developments at QST and throughout Japan
  30. China’s radiopharmaceuticals on expressway: 2014–2021
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https://doi.org/10.1515/ract-2021-1138
Keywords for this article
186W(p,n)186Re; high specific activity (HSA) 186Re; N2S2 ligand (222-MAMA-N-ethylpropionate); ReO(222-MAMA-N-ethylpropionate); tungsten disulfide (WS2)

Articles in the same Issue

  1. Frontmatter
  2. Editorial: Diamond Jubilee Issue
  3. Sixty years of Radiochimica Acta: a brief overview with emphasis on the last 10 years
  4. A. Chemistry of Radioelements
  5. Five decades of GSI superheavy element discoveries and chemical investigation
  6. Chemistry of the elements at the end of the actinide series using their low-energy ion-beams
  7. Sonochemistry of actinides: from ions to nanoparticles and beyond
  8. Theoretical insights into the reduction mechanism of neptunyl nitrate by hydrazine derivatives
  9. The speciation of protactinium since its discovery: a nightmare or a path of resilience
  10. On the volatility of protactinium in chlorinating and brominating gas media
  11. The aqueous chemistry of radium
  12. B. Energy Related Radiochemistry
  13. Selective actinide(III) separation using 2,6-bis[1-(propan-1-ol)-1,2,3-triazol-4-yl]pyridine (PyTri-Diol) in the innovative-SANEX process: laboratory scale counter current centrifugal contactor demonstration
  14. Fate of Neptunium in nuclear fuel cycle streams: state-of-the art on separation strategies
  15. Uranium adsorption – a review of progress from qualitative understanding to advanced model development
  16. Targeted synthesis of carbon-supported titanate nanofibers as host structure for nuclear waste immobilization
  17. Progress of energy-related radiochemistry and radionuclide production in the Republic of Korea
  18. C. Nuclear Data
  19. How accurate are half-life data of long-lived radionuclides?
  20. Status of the decay data for medical radionuclides: existing and potential diagnostic γ emitters, diagnostic β+ emitters and therapeutic radioisotopes
  21. An overview of nuclear data standardisation work for accelerator-based production of medical radionuclides in Pakistan
  22. An overview of activation cross-section measurements of some neutron and charged-particle induced reactions in Bangladesh
  23. Nuclear reaction data for medical and industrial applications: recent contributions by Egyptian cyclotron group
  24. Nuclear data for light charged particle induced production of emerging medical radionuclides
  25. D. Radionuclides and Radiopharmaceuticals
  26. The role of chemistry in accelerator-based production and separation of radionuclides as basis for radiolabelled compounds for medical applications
  27. Production of neutron deficient rare earth radionuclides by heavy ion activation
  28. Evaluation of 186WS2 target material for production of high specific activity 186Re via proton irradiation: separation, radiolabeling and recovery/recycling
  29. Special radionuclide production activities – recent developments at QST and throughout Japan
  30. China’s radiopharmaceuticals on expressway: 2014–2021
  31. E. Environmental Radioactivity
  32. A summary of environmental radioactivity research studies by members of the Japan Society of Nuclear and Radiochemical Sciences
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