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Chemical effects of nuclear transformations and possible formation of unknown derivatives with N-phenylquinazolinium structure

  • Nadezhda E. Shchepina , Viktor V. Avrorin , Gennadii A. Badun , Sergey N. Shurov and Roman V. Shchepin EMAIL logo
Published/Copyright: June 18, 2019
Radiochimica Acta
From the journal Radiochimica Acta Volume 108 Issue 2

Abstract

Quinazoline derivatives are well known to have a diverse array of therapeutic activities. Unfortunately, “classic” chemical synthesis does not provide an opportunity for the formation of N-phenyl quaternary 1,3-diazinium compounds. A devised nuclear-chemical method of synthesis based on chemical effects of nuclear transformations enables a new way of the direct nitrogen atom phenylation by the nucleogenic (generated by tritium β-decay) phenyl cations in 1,3-diazines, furnishing, based on our prediction, formation of previously unknown derivatives with N-phenyl quaternary quinazolinium scaffold.

Keywords: Tritium; quinazoline; nuclear-chemical method; N-phenyl quaternary 1,3-diazinium structure
Corresponding author: Dr. Roman V. Shchepin, Department of Radiology, Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, TN 37232, USA, Phone: +1-615-322-8359, Fax: +1-615-322-0734; and Department of Chemistry and Applied Biological Sciences, South Dakota School of Mines and Technology, Rapid City, SD 57701, USA, Phone: +1-605-394-1238

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Received: 2018-04-14
Accepted: 2019-05-22
Published Online: 2019-06-18
Published in Print: 2020-01-28

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/ract-2018-2970
Keywords for this article
Tritium; quinazoline; nuclear-chemical method; N-phenyl quaternary 1,3-diazinium structure

Articles in the same Issue

  1. Frontmatter
  2. Development of methods for the preparation of radiopure 82Se sources for the SuperNEMO neutrinoless double-beta decay experiment
  3. Determination of 210Po in low-level wild bilberries reference material for quality control assurance in environmental analysis using extraction chromatography and α-particle spectroscopy
  4. Chemical effects of nuclear transformations and possible formation of unknown derivatives with N-phenylquinazolinium structure
  5. An approach for the efficient immobilization of 79Se using Fe-OOH modified GMZ bentonite
  6. Kinetics and mechanism of the advanced oxidation process of Cr(III) to Cr(VI) by SO4−˙ free radicals in slightly acidic simulated atmospheric water
  7. Preparation of novel nano composite materials from biomass waste and their sorptive characteristics for certain radionuclides
  8. Effect of maleic anhydride content on physico-mechanical properties of γ-irradiated waste polypropylene/corn husk fibers bio-composites
  9. Precise volume fraction measurement for three-phase flow meter using 137Cs gamma source and one detector
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