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Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development

  • Rajiv Karmakar and Chhanda Mukhopadhyay EMAIL logo
Published/Copyright: March 17, 2022
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Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 8 Issue 10

Abstract

Benzothiazole scaffolds exhibit exciting medicinal properties including anticancer. In recent time most complicated job for every researcher is to discover a novel drug that can treat cancer with minimal side effects. Some heterocyclic anticancer drugs including daunorubicin, 5-flourouracil, doxorubicin, methotrexate, etc. are markedly available. In addition, few natural products such as vincristine alongwith vinblastine are used as anticancer drugs. More than 90% of the novel drugs bearing heterocyclic moieties have always been main portions in the development of anticancer drugs. Heterocyclic compounds containing benzothiazole moiety show a superior pharmaceutical effect than non-nitrogen compounds. These N-/S-containing benzothiazole compounds, the heart of drug discovery, present a significant and valuable group of molecules that play a chief and vital role in our living cells. This chapter recites the weightage of benzothiazole nuclei in the progress of anticancer drugs.

Keywords: anticancer agent; benzothiazole; drugs development; molecular docking studies; synthesis
Corresponding author: Chhanda Mukhopadhyay, Department of Chemistry, University of Calcutta, 92 APC Road, Kolkata 700009, India, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Published Online: 2022-03-17

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https://doi.org/10.1515/psr-2021-0044
Keywords for this article
anticancer agent; benzothiazole; drugs development; molecular docking studies; synthesis

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  13. Molecular docking and MD: mimicking the real biological process
  14. Synthesis of quinazolinone and quinazoline derivatives using green chemistry approach
  15. Nuclear fusion: the promise of endless energy
  16. Finance for Green Chemistry through Currency Mix
  17. Synthesis of bioactive scaffolds catalyzed by agro-waste-based solvent medium
  18. Recent developments in the green synthesis of biologically relevant cinnolines and phthalazines
  19. Detection of Rapid Eye Movement Behaviour Sleep Disorder using Time and Frequency Analysis of EEG Signal Applied on C4-A1 Channels
  20. Recent developments in C–C bond formation catalyzed by solid supported palladium: a greener perspective
  21. Visible-light-mediated metal-free C–Si bond formation reactions
  22. An overview of quinoxaline synthesis by green methods: recent reports
  23. Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs
  24. Synthesis of bioactive natural products and their analogs at room temperature – an update
  25. One-pot multi-component synthesis of diverse bioactive heterocyclic scaffolds involving 6-aminouracil or its N-methyl derivatives as a versatile reagent
  26. Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development
  27. Triazine based chemical entities for anticancer activity
  28. Modification of kaolinite/muscovite clay for the removal of Pb(II) ions from aqueous media
  29. In silico design of ACE2 mutants for competitive binding of SARS-CoV-2 receptor binding domain with hACE2
  30. Computational study of Cu n AgAu (n = 1–4) clusters invoking DFT based descriptors
  31. Development of an online assessment system to evaluate knowledge on chemical safety and security
  32. Developing a questionnaire for diabetes mellitus type 2 risk effects and precondition factors – multivariate statistical paths
  33. Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae)
  34. The stability increase of α-amylase enzyme from Aspergillus fumigatus using dimethyladipimidate
  35. Sustainability of ameliorative potentials of urea spiked poultry manure biochar types in simulated sodic soils
  36. Cytotoxicity test and antibacterial assay on the compound produced by the isolation and modification of artonin E from Artocarpus kemando Miq.
  37. Effects of alum, soda ash, and carbon dioxide on 40–50 year old concrete wastewater tanks
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