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SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications

  • Ralf P. Friedrich , Christina Janko , Harald Unterweger , Stefan Lyer and Christoph Alexiou EMAIL logo
Published/Copyright: July 12, 2021
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Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 8 Issue 8

Abstract

In the past decades, a wide variety of different superparamagnetic iron oxide nanoparticles (SPIONs) have been synthesized. Due to their unique properties, such as big surface-to-volume ratio, superparamagnetism and comparatively low toxicity, they are principally well suited for many different technical and biomedical applications. Meanwhile, there are a numerous synthesis methods for SPIONs, but high requirements for biocompatibility have so far delayed a successful translation into the clinic. Moreover, depending on the planned application, such as for imaging, magnetic drug targeting, hyperthermia or for hybrid materials intended for regenerative medicine, specific physicochemical and biological properties are inevitable. Since a summary of all existing SPION systems, their properties and application is far too extensive, this review reports on selected methods for SPION synthesis, their biocompatibility and biomedical applications.

Keywords: nanomedicine; regenerative medicine; SPION production; T cell therapy; thrombolysis; vascular prostheses
Corresponding author: Christoph Alexiou, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship Universitätsklinikum, Erlangen, Germany, E-mail:

Funding source: Deutsche Forschungsgemeinschaft 10.13039/501100001659

Award Identifier / Grant number: SPP1681: Grant Number: AL 552/5

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was supported by the Deutsche Forschungsgemeinschaft (SPP1681: Grant Number: AL 552/5).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2020-01-16
Accepted: 2021-06-08
Published Online: 2021-07-12

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Influence of lime (CaO) on low temperature leaching of some types of bauxite from Guinea
  4. Ethnobotanical survey, phytoconstituents and antibacterial investigation of Rapanea melanophloeos (L.) Mez. bark, fruit and leaf extracts
  5. Catalytic properties of supramolecular polymetallated porphyrins
  6. Lignin-based polymers
  7. Bio-based polyhydroxyalkanoates blends and composites
  8. Biodegradable poly(butylene adipate-co-terephthalate) (PBAT)
  9. Repurposing tires – alternate energy source?
  10. Theoretical investigation of the stability, reactivity, and the interaction of methyl-substituted peridinium-based ionic liquids
  11. Polymeric membranes for biomedical applications
  12. Design of locally sourced activated charcoal filter from maize cob for wastewater decontamination: an approach to fight waste with waste
  13. Synthesis of biologically active heterocyclic compounds from allenic and acetylenic nitriles and related compounds
  14. Magnetic measurement methods to probe nanoparticle–matrix interactions
  15. Health and exposure risk assessment of heavy metals in rainwater samples from selected locations in Rivers State, Nigeria
  16. Evaluation of raw, treated and effluent water quality from selected water treatment plants: a case study of Lagos Water Corporation
  17. A chemoinformatic analysis of atoms, scaffolds and functional groups in natural products
  18. Hemicyanine dyes
  19. Thermodynamics of the micellization of quaternary based cationic surfactants in triethanolamine-water media: a conductometry study
  20. Compounds isolated from hexane fraction of Alternanthera brasiliensis show synergistic activity against methicillin resistant Staphylococcus aureus
  21. Internal structures and mechanical properties of magnetic gels and suspensions
  22. SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications
  23. Magnetic field controlled behavior of magnetic gels studied using particle-based simulations
  24. The microstructure of magnetorheological materials characterized by means of computed X-ray microtomography
  25. Core-modified porphyrins: novel building blocks in chemistry
  26. Anticancer potential of indole derivatives: an update
  27. Novel drug design and bioinformatics: an introduction
  28. Multi-objective optimization of CCUS supply chains for European countries with higher carbon dioxide emissions
  29. Exergy analysis of an atmospheric residue desulphurization hydrotreating process for a crude oil refinery
  30. Development in nanomembrane-based filtration of emerging contaminants
  31. Supply chain optimization framework for CO2 capture, utilization, and storage in Germany
  32. Naturally occurring heterocyclic anticancer compounds
  33. Part-II- in silico drug design: application and success
  34. Advances in biopolymer composites and biomaterials for the removal of emerging contaminants
  35. Nanobiocatalysts and photocatalyst in dye degradation
  36. 3D tumor model – a platform for anticancer drug development
  37. Hydrogen production via water splitting over graphitic carbon nitride (g-C3N4 )-based photocatalysis
https://doi.org/10.1515/psr-2019-0093
Keywords for this article
nanomedicine; regenerative medicine; SPION production; T cell therapy; thrombolysis; vascular prostheses

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Influence of lime (CaO) on low temperature leaching of some types of bauxite from Guinea
  4. Ethnobotanical survey, phytoconstituents and antibacterial investigation of Rapanea melanophloeos (L.) Mez. bark, fruit and leaf extracts
  5. Catalytic properties of supramolecular polymetallated porphyrins
  6. Lignin-based polymers
  7. Bio-based polyhydroxyalkanoates blends and composites
  8. Biodegradable poly(butylene adipate-co-terephthalate) (PBAT)
  9. Repurposing tires – alternate energy source?
  10. Theoretical investigation of the stability, reactivity, and the interaction of methyl-substituted peridinium-based ionic liquids
  11. Polymeric membranes for biomedical applications
  12. Design of locally sourced activated charcoal filter from maize cob for wastewater decontamination: an approach to fight waste with waste
  13. Synthesis of biologically active heterocyclic compounds from allenic and acetylenic nitriles and related compounds
  14. Magnetic measurement methods to probe nanoparticle–matrix interactions
  15. Health and exposure risk assessment of heavy metals in rainwater samples from selected locations in Rivers State, Nigeria
  16. Evaluation of raw, treated and effluent water quality from selected water treatment plants: a case study of Lagos Water Corporation
  17. A chemoinformatic analysis of atoms, scaffolds and functional groups in natural products
  18. Hemicyanine dyes
  19. Thermodynamics of the micellization of quaternary based cationic surfactants in triethanolamine-water media: a conductometry study
  20. Compounds isolated from hexane fraction of Alternanthera brasiliensis show synergistic activity against methicillin resistant Staphylococcus aureus
  21. Internal structures and mechanical properties of magnetic gels and suspensions
  22. SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications
  23. Magnetic field controlled behavior of magnetic gels studied using particle-based simulations
  24. The microstructure of magnetorheological materials characterized by means of computed X-ray microtomography
  25. Core-modified porphyrins: novel building blocks in chemistry
  26. Anticancer potential of indole derivatives: an update
  27. Novel drug design and bioinformatics: an introduction
  28. Multi-objective optimization of CCUS supply chains for European countries with higher carbon dioxide emissions
  29. Exergy analysis of an atmospheric residue desulphurization hydrotreating process for a crude oil refinery
  30. Development in nanomembrane-based filtration of emerging contaminants
  31. Supply chain optimization framework for CO2 capture, utilization, and storage in Germany
  32. Naturally occurring heterocyclic anticancer compounds
  33. Part-II- in silico drug design: application and success
  34. Advances in biopolymer composites and biomaterials for the removal of emerging contaminants
  35. Nanobiocatalysts and photocatalyst in dye degradation
  36. 3D tumor model – a platform for anticancer drug development
  37. Hydrogen production via water splitting over graphitic carbon nitride (g-C3N4 )-based photocatalysis
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