Startseite Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)
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Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)

  • Tati Suhartati EMAIL logo , Andi Irawan , Hendri Ropingi , Yandri Yandri und Sutopo Hadi
Veröffentlicht/Copyright: 14. Februar 2024
Pure and Applied Chemistry
Aus der Zeitschrift Pure and Applied Chemistry Band 96 Heft 3

Abstract

In this study, artocarpin compound was successfully isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.) and subsequently tested as antidiabetic and antibacterial agent against Staphylococcus aureus and Salmonella typhi. The procedure applied for isolation involved maceration using methanol followed by partition and purification using column chromatography. The purity of the compound was determined using thin layer chromatography and melting point measurement. The compound was subsequently characterized via UV–vis and IR spectroscopy. The compound isolated was obtained as a yellow amorphous solid and has melting point of 168.7–173.6 °C. The antidiabetic tests were performed against α-amylase enzyme, using the compound with the concentrations of 250, 500, 750, and 1000 ppm. The highest inhibition percentage of 43.33 ± 0.02 % was achieved with the use of 750 ppm of the compound and the IC50 value is 32 661.08 ppm. Antibacterial tests were performed with concentration variations of 0.3, 0.4, and 0.5 mg/disc. S. aureus and S. typhi bacteria showed high inhibition at a concentration of 0.5 mg/disc with inhibition zone diameters of 8 and 7 mm, respectively (moderate category).

Keywords: A. kemando Miq.; antibacterial; antidiabetic; artocarpin; S. aureus ; S. typhi ; VCCA-2023
Corresponding author: Tati Suhartati, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Lampung, Bandar Lampung 35145, Indonesia, e-mail:
Article note: A collection of invited papers based on presentations at the Virtual Conference on Chemistry and its Applications 2023 (VCCA-2023).

  1. Research funding: The author would like to thank the Ministry of Education, Culture, Research and Technology, for funding support in the form of Basic Research, fiscal year 2023 with contract number 027/E5/PG.02.00.PL/2023 on 12th April 2023 and 2192/UN26.21/PN/2023 on 17th April 2023.

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Published Online: 2024-02-14
Published in Print: 2024-03-25

© 2024 IUPAC & De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. In this issue
  3. Preface
  4. The virtual conference on chemistry and its applications, VCCA-2023, 7–11 August 2023
  5. Special topic papers
  6. Recovery of wipe sampling of urban surfaces contaminated with blistering chemical warfare agents
  7. Bioremediation of cadmium contaminated soil by tea waste and impact on the accumulation of Cd in Helianthus annuus
  8. Exploring the potential of Meldrum’s acid-bearing chain extenders for mechanical recycling of PET
  9. In silico and in vitro profiling of coumarins and flavonoids for anti-Alzheimer and antioxidant activity
  10. MTT assay of human anti-breast cancer cells (MCF-7) in vitro potentials and phytochemicals screening of the root bark extracts from Cassia sieberiana
  11. Synthesis of some chalcones derivatives series and their antituberculosis activity
  12. Luminescence of silver, thulium and ytterbium doped oxyfluoride glasses
  13. Two new naturally dimers constituent from Indonesian Sesbania grandiflora plant and their bioactivity
  14. Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)
  15. Unraveling the influence of biomaterial’s functional groups in Cd biosorption: a density functional theory calculation
  16. Synthesis, characterization, and bioactivity test of dibutyltin(IV) dihydroxyibenzoate as disinfectant agent
  17. Computational investigation of thallium interactions with functionalized multi-walled carbon nanotubes for electrochemical sensing applications
  18. Conversion of elemental phosphorus under the electron beam irradiation
  19. Advances in understanding comproportionation and disproportionation in nickel catalysis
https://doi.org/10.1515/pac-2023-1131
Schlagwörter für diesen Artikel
A. kemando Miq.; antibacterial; antidiabetic; artocarpin; S. aureus; S. typhi; VCCA-2023

Artikel in diesem Heft

  1. Frontmatter
  2. In this issue
  3. Preface
  4. The virtual conference on chemistry and its applications, VCCA-2023, 7–11 August 2023
  5. Special topic papers
  6. Recovery of wipe sampling of urban surfaces contaminated with blistering chemical warfare agents
  7. Bioremediation of cadmium contaminated soil by tea waste and impact on the accumulation of Cd in Helianthus annuus
  8. Exploring the potential of Meldrum’s acid-bearing chain extenders for mechanical recycling of PET
  9. In silico and in vitro profiling of coumarins and flavonoids for anti-Alzheimer and antioxidant activity
  10. MTT assay of human anti-breast cancer cells (MCF-7) in vitro potentials and phytochemicals screening of the root bark extracts from Cassia sieberiana
  11. Synthesis of some chalcones derivatives series and their antituberculosis activity
  12. Luminescence of silver, thulium and ytterbium doped oxyfluoride glasses
  13. Two new naturally dimers constituent from Indonesian Sesbania grandiflora plant and their bioactivity
  14. Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)
  15. Unraveling the influence of biomaterial’s functional groups in Cd biosorption: a density functional theory calculation
  16. Synthesis, characterization, and bioactivity test of dibutyltin(IV) dihydroxyibenzoate as disinfectant agent
  17. Computational investigation of thallium interactions with functionalized multi-walled carbon nanotubes for electrochemical sensing applications
  18. Conversion of elemental phosphorus under the electron beam irradiation
  19. Advances in understanding comproportionation and disproportionation in nickel catalysis
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